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Sleeping Beauty Goes Germline – A New Technology for Gene Transfer

Scientists at the Paul Ehrlich Institute report on an efficient method to move genes into the germline of experimental animals in three publications appearing in the current issue of Nature Protocols.

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Changes in electronic submissions of regulatory documents to the Paul-Ehrlich-Institut

Important changes apply to submissions of regulatory documents. The so-called requirement of "written form" which means that paper copies of submissions must be supplied bearing the signature of the applicant in ink no longer applies to many documents. A new introduction is PEI-C Rebuild, a portal for electronic submissions of applications for batch releases. These changes and a few additional ones are summarised in this section.

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Xenotransplantation – no replication of porcine endogenous retroviruses in human cell culture

Transplantations of animal cells, tissues, or organs to humans (xenotransplantion) could in future solve the problem of short organ supply. It must, however, be guaranteed that no pathogenic agents from animals are transmitted to the human body. Researchers at the Paul-Ehrlich-Institut have now been able to prove that although porcine endogenous retroviruses (PERV) can penetrate human blood cells under certain circumstances, they cannot replicate at these sites.

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