Why is the immune system unable to combat HIV? Key factor identified
An international research group with essential participation of the Paul-Ehrlich-Institut, has identified NLRX1, a cellular factor of the human cell that is indispensable to the replication of Human Immunodeficiency Virus (HIV-1). This factor plays a key role in attenuating the innate immune system towards HIV-1. Until now, the significance of NLRX1 for the replication of HIV-1 and the attenuation of the immune system was not known. The novel research finding will lead to new therapeutic approaches.
Mouse model suitable for predicting cytokine storm by antibodies such as TGN1412
Researchers of the Paul-Ehrlich-Institut have developed a humanised mouse model that can be used to predict severe adverse immune reactions after administration of the monoclonal antibody TGN1412. A few years ago, the antibody led to severe immune reactions as a result of a cytokine storm in a clinical trial with healthy volunteers.
Experimental evidence for a novel mechanism of transposition – Vector choice and gene transfer
Transposons are mobile DNA segments that can cause disease, for example cancer, when they move to new locations in the genome. However, transposons can also be harnessed as tools for gene therapy of genetic diseases. Scientists at the Paul-Ehrlich-Institut, that evaluates such advanced therapies, discovered a new mechanism of genome shuffling by transposons.