Is a small artificially composed virus fragment the key to a Chikungunya vaccine?
The mosquito transmitted Chikungunya virus, which causes Chikungunya fever, is spreading continuously. No vaccine is so far available. Researchers of the Paul-Ehrlich-Institut have experimentally recombined segments of the virus surface protein E2, thus creating artificial proteins.
Death for life – The Leishmania parasite needs dead competitors to outwit the immune system
Researchers at the Paul-Ehrlich-Institut have found out how unicellular parasites succeed in tricking our immune system. To be successful, live and dead leishmania parasites must enter the host cells simultaneously. The dead Leishmania are degraded in the cell by means of a self-digestion mechanism (autophagy).
Precise gene transfer into therapy relevant cells after vector injection into blood
Therapeutic gene transfer is considered as a promising novel strategy to treat genetic disorders and cancer. So far, target cells are often isolated from patients for this purpose, and re-administered after gene transfer. In collaboration with colleagues from the Universities of Cologne and Zurich, researchers at the Paul-Ehrlich-Institut have succeeded in developing gene transfer vehicles that target the therapy relevant cell type directly in the organism.