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Important intrinsic factor for the defence against hepatitis B viruses identified – consequences for treatment?

Around 350 million people are chronically infected with the hepatitis B virus world-wide. This is related to a markedly increased risk of liver cancer and liver cirrhosis. Researchers of the Paul-Ehrlich-Institut have discovered an intrinsic cellular factor, SAMHD1, which is upregulated by interferons and inhibits the hepatitis B infection.

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Why is the immune system unable to combat HIV? Key factor identified

An international research group with essential participation of the Paul-Ehrlich-Institut, has identified NLRX1, a cellular factor of the human cell that is indispensable to the replication of Human Immunodeficiency Virus (HIV-1). This factor plays a key role in attenuating the innate immune system towards HIV-1. Until now, the significance of NLRX1 for the replication of HIV-1 and the attenuation of the immune system was not known. The novel research finding will lead to new therapeutic approaches.

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Mouse model suitable for predicting cytokine storm by antibodies such as TGN1412

Researchers of the Paul-Ehrlich-Institut have developed a humanised mouse model that can be used to predict severe adverse immune reactions after administration of the monoclonal antibody TGN1412. A few years ago, the antibody led to severe immune reactions as a result of a cytokine storm in a clinical trial with healthy volunteers.

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