Successful outcome of Voluntary Harmonsation Procedure for clinical trials in Europe

Three years ago, the Voluntary Harmonisation procedure (VHP) started under the auspices of the Paul-Ehrlich-Institut (PEI). The procedure enables applicants to process authorisations of clinical trials in several European countries simultaneously. The situation was reviewed after three years and showed a positive outcome: The time that elapses before a multinational clinical trial is authorised in all participating EU countries could be reduced to less than three months.

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Appearance of HIV in the early warning system – camouflage uncovered

While the human immunodeficiency virus replicates extremely rapidly in some of the human immune cells, other cells remain unaffected. Researchers of the Paul-Ehrlich-Institut have been able to identify how monocytes protect themselves from an HIV infection.

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Successful combination of virtual screening and cell culture research: Interferon inhibitor discovered

Interferon alpha plays a central role in severe autoimmune disorders. Inhibitors are not available to date. In collaboration with researchers of the ETH Zurich, Switzerland, scientists at the Paul-Ehrlich-Institut have now succeeded in identifying a substance that inhibits interferon alpha release. To achieve this, they have combined computer-based molecular design methods with optimised in-vitro assays.

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