Publikationen aus 2003

Autorinnen und Autoren des Paul-Ehrlich-Instituts sind durch Fettdruck kenntlich gemacht. Wenn Online-Abstracts oder Volltexte zu den Publikationen verfügbar sind, so sind diese verlinkt.

Avidan O, Loya S, Tönjes RR, Sevilya Z, Hizi A (2003): Expression and characterization of a recombinant novel reverse transcriptase of a porcine endogenous retrovirus.
Virology 307: 341-357.

Ballmer-Weber BK, Scheurer S, Vieths S (2003): Update: Kreuzreaktivität zwischen Allergenen in Nahrungsmitteln und Birkenpollen.
Allergologie 26: 463-473.

Ballmer-Weber BK, Wangorsch A, Scheurer S: Recombinant food allergens in the diagnosis of pollen-related food allergy.
In: Löwer J, Becker WM, Vieths S (Hrsg.), Regulatory Control and Standardization of Allergenic Extracts: 10th International Paul-Ehrlich-Seminar October 2-5, 2002, Lübeck. Frankfurt a. M.: Sperlich, 2003. 192-196 ISBN 3-00-012888-3
(Arbeiten aus dem Paul-Ehrlich-Institut 94)

Brockow K, Hautmann C, Fötisch K, Rakoski J, Borelli S, Vieths S, Ring J (2003): Orange-induced skin lesions in patients with atopic eczema - evidence for a non-IgE-mediated pathomechanism.
Acta Derm Venerol 83: 44-48.

Bruckner L, Cußler K, Halder M, Barrat J, Castle P, Duchow K, Gatewood DM, Gibert R, Groen J, Knapp B, Levis R, Milne C, Parker S, Stünkel K, Visser N, Volkers P (2003): Three Rs approaches in the quality control of inactivated rabies vaccines. The report and recommendations of ECVAM workshop 48.
ATLA 31: 429-454.

Damert A, Kusserow H (2003): Generation of transgenic mice by pronuclear injection.
Methods Mol Med 89: 513-528.

Dodt J, Reichwein J (2003): Human Cathepsin H: Deletion of the Mini-Chain Switches Substrate Specificity from Aminopeptidase to Endopeptidase.
Biol Chem 384: 1327-1332.

Eich S, Kusch M, Grundmann C, Hanker C, Seitz R, König H (2003): Factor VIII determination in patient's plasma and concentrates: a novel test equally suited for both matrices.
Blood Coagul Fibrinolysis 14: 347-353.

Erlwein O, Buchholz CJ, Schnierle BS (2003): The proline-rich region of the ecotropic Moloney murine leukaemia virus envelope protein tolerates the insertion of the green fluorescent protein and allows the generation of replication-competent virus.
J Gen Virol 84: 369-373.

Fernandes J, Reshef A, Patton L, Ayuso R, Reese G, Lehrer SB (2003): Immunoglobulin E antibody reactivity to the major shrimp allergen, tropomyosin, in unexposed Orthodox Jews.
Clin Exp Allergy 33: 956-961.

Fischer N, Krach U, Niebert M, Tönjes RR (2003): Detection of porcine endogenous retrovirus (PERV) using highly specific antisera against Gag and Env.
Virology 311: 222-228.

Fleischmann A, Hvalby O, Jensen V, Strekalova T, Zacher C, Layer LE, Kvello A, Reschke M, Spanagel R, Sprengel R, Wagner EF, Gass P (2003): Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS.
J Neurosci 23: 9116-9122.

Fötisch K, Westphal S, Lauer I, Retzek M, Altmann F, Kolarich D, Scheurer S, Vieths S (2003): Biological activity of IgE specific for cross-reactive carbohydrate determinants (CCD).
J Allergy Clin Immunol 111: 889-896.

Graul A, Heiden M, Gräf K, Keller-Stanislawski B (2003): Hämovigilanz in Deutschland - Bericht an das Paul-Ehrlich-Institut über Verdachtsfälle von Transfusionsreaktionen im Beobachtungszeitraum Januar 1995 bis Dezember 2002.
Transfus Med Hemother 30: 232-238.

Haigh JJ, Morelli PI, Gerhardt H, Haigh K, Tsien J, Damert A, Miquerol L, Muhlner U, Klein R, Ferrara N, Wagner EF, Betsholtz C, Nagy A (2003): Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling.
Dev Biol 262: 225-241.

Hangartner L, Senn BM, Ledermann B, Kalinke U, Seiler P, Bucher E, Zellweger RM, Fink K, Odermatt B, Bürki K, Zinkernagel RM, Hengartner H (2003): Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies.
PNAS Epub Oct 20; 100: 12883-12888.

Hartinger J, Külbs D, Volkers P, Cussler K (2003): Suitability of temperature-sensitive transponders to measure body temperature during animal experiments required for regulatory tests.
ALTEX 20: 65-70.

Hartmann S, Sollwedel A, Hoffmann, A, Sonnenburg B, Lucius R (2003): Characterization of IgE responses in a rodent model of filariasis and the allergenic potential of filarial antigens using an in vitro assay.
Parasite Immunol 25: 9-16.

Hoff M, Ballmer-Weber BK, Niggemann B, Cistero-Bahima A, San Miguel-Moncín M, Conti A, Haustein D, Vieths S (2003): Molecular cloning and immunological characterization of potential allergens from the mold Fusarium culmorum.
Mol Immunol 39: 965-975.

Hoff M, Trueb RM, Ballmer-Weber K, Vieths S, Wüthrich B (2003): Immediate-type hypersensitivity reaction to ingestion of mycoprotein (Quorn) in a patient allergic to molds caused by acidic ribosomal protein P2.
J Allergy Clin Immunol 111: 1106-1110.

Hoffmann A, Kaul S, Fötisch K, Danz N, Lüttkopf D, Hatahet L, Kastner B, Vogel L, Höltz G, Vieths S (2003): Mediator release assays based on human and murine IgE: potential and limitations in allergen standardization.
Arbeiten aus dem Paul-Ehrlich-Institut 94: 76-85.

Hoffmann A, Werner E, Mergel A, Cußler K (2003): Unerwünschte Wirkungen nach Applikation immunologischer Arzneimittel beim Tier: Zusammenfassung der Meldungen im Zeitraum von 1998 bis 2002.
Dtsch Tierärztebl: 1246-1251.

Hubbard AR, Sands D, Sandberg E, Seitz R, Barrowcliffe TW (2003): A multi-centre collaborative study on the potency estimation of ReFacto.
Thromb Haemost 90: 1088-1093.

Johannes S, Hartinger J, Hendriksen C, Morton DB, Cussler K (2003): Humane endpoints in the efficacy testing of swine erysipelas vaccines.
ALTEX 20: 11-15.

Kaul S, Scheurer S, Danz N, Schicktanz S, Vieths S, Hoffmann A (2003): Monoclonal IgE antibodies against birch pollen allergens: novel tools for biological characterization and standardization of allergens.
J Allergy Clin Immunol 111: 1262-81.

Keller-Stanislawski B, Löwer J (2003): Todesfälle in zeitlichem Zusammenhang mit Sechsfachimpfung.
Kinder und Jugendarzt 34: 608-613.

Klein H, Mueller S, Loeschner B, Toenjes RR, Braun G, Mueller EC, Otto A, Montag T (2003): Cloning, sequencing and recombinant expression of the open reading frame encoding a novel member of the Sarcocystis muris (Apicomplexa) microneme lectin family.
Parasitol Res 90: 84-86.

Kootstra Na, Münk C, Tonnu N, Landau NR, Verma Im (2003): Abrogation of postentry restriction of HiV-1-based lentiviral vector transduction in simian cells.
Proc Natl Acad Sci 100: 1298-1303.

Krach K, Badenhoop K, Tönjes RR (2003): The IDDM associated solitary retroviral promoters DQ-LTR3 and DQ-LTR13 have a distinct impact on the expression of selected DQB1 genes in different cell lines in vitro.
Immunogenetics 55: 521-529.

Krach U, Fischer N, Scheef G, Czauderna F, Tönjes RR: Xenogene porzine endogene Retroviren: Genetik und Wirtszellspezifität.
In: Grimm H (Hrsg.), Xenotransplantation, Grundlagen - Chancen - Risiken. Stuttgart, New York: Schattauer, 2003. 213-226. ISBN 3-7945-2058-0

Krach K, Pani MA, Seidl C, Van der Auwera BJ, Gorus FK, Tönjes RR, Badenhoop K, Van Autreve J (2003): DQ-LTR13 modifies type I diabetes (IDDM) susceptibility on high risk DQ haplotypes: reply to the comments of Pascual et al.
Diabetologia 46: 870-871.

Lehrer SB, Ayuso R, Reese G (2003): Seafood allergy and allergens: a review.
Mar Biotechnol 5: 339-348.

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) Langen (Hessen).
Löwer J, Becker WM, Vieths S (Hrsg.), Regulatory Control and Standardization of Allergenic Extracts: 10th International Paul-Ehrlich-Seminar October 2-5, 2002, Lübeck. Frankfurt a. M.: Sperlich, 2003. 340 S. ISBN 3-00-012888-3
(Arbeiten aus dem Paul-Ehrlich-Institut 94)

Merten CA, Engelstaedter M, Buchholz CJ, Cichutek K (2003): Displaying epidermal growth factor on spleen necrosis virus-derived targeting vectors.
Virology 305: 106-114.

Mühlebach MD, Schmitt I, Steidl S, Stitz J, Schweizer M, Blankenstein T, Cichutek K, Uckert W (2003): Transduction efficiency of MLV but not of HIV-1 vectors is pseudotype dependent on human primary T lymphocytes.
J Mol Med 81: 801-810.

Münk C, Landau NR (2003): Production and Use of HIV-1 Luciferase Reporter viruses.
Current Protocols in Pharmacology 12.5.1-12.5.12.

Muenk C, Prassolov V, Rodenburg M, Kalinin V, Löhler J, Stocking C (2003): 10A1-MuLV but not the related amphotropic 4070A MuLV is highly neurovirulent: importance of sequences upstream of the structural Gag coding region.
Virology 313: 44-55.

Münk C, Wei G, Yang OO, Waring AJ, Wang W, Hong T, Lehrer RI, Landau NR, Cole AA (2003): The theta-defensin, Retrocyclin, inhibits HIV-1 entry.
AIDS Res Hum Retroviruses 19: 875-881.

Muster T, Waltenberger A, Grassauer A, Hirschl S, Caucig P, Romirer I, Fodinger D, Seppele H, Schanab O, Magin-Lachmann C, Löwer R, Jansen B, Pehamberger H, Wolff K (2003): An endogenous retrovirus derived from human melanoma cells.
Cancer Res 63: 8735-8741.

Neudecker P, Lehmann K, Nerkamp J, Haase T, Wangorsch A, Fötisch K, Rösch P, Vieths S, Scheurer S (2003): Mutational epitope analysis of Pru av 1 and Api g 1, the major allergens of cherry (Prunus avium) and celery (Apium graveolens): correlating IgE reactivity with three-dimensional structure.
Biochemical J 376: 97-107.

Niebert M, Kurth R, Tönjes RR (2003): Retroviral safety: analyses of phylogeny, prevalence and polymorphisms of porcine endogenous retroviruses.
Ann Transplant 8: 56-64.

Niebert M, Tönjes RR: Molecular Cloning and Functional Characterization of Infectious PERV and Development of Diagnostic Tests.
In: Salomon DR, Wilson C (eds.), Xenotransplantation. Heidelberg: Springer, 2003. 217-237.
(Current Topics in Microbiology and Immunology 278)

Niebert M, Tönjes RR (2003): Analyses of prevalence and polymorphisms of six replication-competent and chromosomally assigned porcine endogenous retroviruses in individual pigs and pig subspecies.
Virology 313: 427-434.

Nübling CM, Chudy M, Löwer J (2003): Neopterin determination during the diagnostic window phase of HIV-1, HBV and HCV infections.
Pteridines 14: 53.

Nübling CM, Daas A, Buchheit KH (2003): Collaborative Study for Establishment of a European Pharmacopoeia Biological Reference Preparation (BRP) for B19 Virus DNA Testing of Plasma Pools by Nucleic Acid Amplification Technique.
Pharmeuropa Bio 2003: 27-34.

Bekanntmachung des Paul-Ehrlich-Institutes (2003): Bericht zur Meldung nach § 21 TFG für die Jahre 1999 und 2000.
Bundesgesundheitsbl-Gesundheitsforsch-Gesundheitsschutz 46: 1016-1032.

Roßkopf-Streicher U, Volkers P, Schindler M, Noeske K, Werner E (2003): Collaborative study on the validation of an indirect competition ELISA for detection of protective antibodies in rabbit sera against C. perfringens type B and D vaccines for veterinary use (batch potency test).
Final report BMBF Projekt Nr. 0312636.

Rosskopf-Streicher U, Volkers P, Werner E (2003): Control of Clostridium perfringens Vaccines using an Indirect Competitive ELISA for the Epsilon Toxin Component..
Pharmeuropa Bio 2003-2: 91-96.

San Miguel-Moncín M, Krail M, Scheurer S, Enrique E, Alonso R, Conti A, Cisteró-Bahíma A, Vieths S (2003): Lettuce anaphylaxis: identification of a lipid transfer protein as the major allergen.
Allergy 58: 511-7.

Schäffner G, Kayser T, Tönjes A, Volkers P (2003): Validation of flow cytometry to quantify the potency of anti-D immunoglobulin preparations.
Vox Sang 84: 129-136.

Schneider R, Medvedovska J, Hartl I, Voelker B, Chadwick MP, Russell SJ, Cichutek K, Buchholz CJ (2003): Directed evolution of retroviruses activatable by tumour-associated matrix metalloproteases.
Gene Ther 10: 1370-1380.

Seitz R, Burger R, Gerlich W, Gürtler L, Heiden M, Hitzler W, Jansen B, Klamm H, Lefèvre H, Löwer J, Ludwig WD, Montag-Lessing T, Offergeld R, Paessens A, Pauli G, Schlenkrich U, Werner E, Willkommen H (2003): Hepatitis-C-Virus.
Bundesgesundheitsbl – Gesundheitsforsch – Gesundheitsschutz 46: 712-722.

Seitz R, Burger R, Gerlich W, Gürtler L, Heiden M, Hitzler W, Jansen B, Klamm H, Lefèvre H, Löwer J, Ludwig WD, Montag-Lessing T, Paessens A, Pauli G, Schlenkrich U, Werner E, Willkommen H, Hagedorn HJ (2003): Treponema pallidum.
Transfus Med Hemother 30: 134-143.

Seitz R, Burger R, Gerlich W, Gürtler L, Heiden M, Hitzler W, Jansen B, Klamm H, Lefèvre H, Löwer J, Ludwig WD, Montag-Lessing T, Paessens A, Pauli G, Schlenkrich U, Werner E, Willkommen H (2003): Hepatitis-C-Virus.
Transfus Med Hemother 30: 239-250.

Seitz R, Keller-Stanislawski B, Heiden M (2003): A vér-készitmények mellékhatásai és ellenörzésének haemovigilance módszerei (Nebenwirkungen von Blutkomponenten - Hämovigilanz und Initiativen).
Transzfúzió 35: 187-192.

Seitz R (2003): Standardisation of Plasma Products.
Transfus Med Hemother 30: 124-128.

Senn BM, López-Macías C, Kalinke U, Lamarre A, Isibasi A, Zinkernagel RM, Hengartner H (2003): Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections.
Eur J Immunol 33: 950-961.

Skamstrup Hansen K, Ballmer-Weber BK, Lüttkopf D, Skov PS, Wüthrich B, Bindslev-Jensen C, Vieths S, Poulsen LK (2003): Roasted hazelnuts - allergenic activity evaluated by double-blind, placebo-controlled food challenge.
Allergy 58: 132-138.

Tönjes RR, Niebert M (2003): Relative age of proviral porcine endogenous retrovirus sequences in Sus scrofa based on the molecular clock hypothesis.
J Virol 77: 12363-12368.

Werfel T, Fuchs T, Reese I, Erdmann S, Henzgen M, Kleine-Tebbe J, Lepp U, Niggemann B, Saloga J, Vieluf I, Vieths S, Zuberbier T (2003): Vorgehen bei vermuteter Nahrungsmittelallergie bei atopischer Dermatitis: Positionspapier der Arbeitsgruppe Nahrungsmittelallergie der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAI).
Allergologie 26: 33-41.

Westphal S, Kolarich D, Fötisch K, Lauer I, Altmann F, Conti A, Crespo JF, Rodriguez J, Enrique E, Vieths S, Scheurer S (2003): Molecular characterization and allergenic activity of Lyc e 2 (beta-fructofuranosidase), a glycosylated allergen of tomato.
Eur J Biochem 270: 1327-1337.