Paul-Ehrlich-Institut

Publikationen Dr. Egbert Flory

Autorinnen und Autoren des Paul-Ehrlich-Instituts sind durch Fettdruck kenntlich gemacht. Wenn Online-Abstracts oder Volltexte zu den Publikationen verfügbar sind, so sind diese verlinkt.

Theuerkauf SA, Michels A, Riechert V, Maier TJ, Flory E, Cichutek K, Buchholz CJ (2021): Quantitative Assays Reveal Cell Fusion at Minimal Levels of SARS-CoV-2 Spike Protein and Fusion-from-Without.
iScience Feb 9 [Epub ahead of print].
Online-Abstract

Riess M, Fuchs NV, Idica A, Hamdorf M, Flory E, Pedersen IM, König R (2017): Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
J Biol Chem 292: 264-277.
Online-Abstract

Flory E, Riess M, Hein-Fuchs N, König R (2016): Aids: Scharade für das Immunsystem.
Dtsch Arztebl 113: A-1436 / B-1213 / C-1193.
Text

Renner M, Anliker B, Flory E, Scherer J, Schüßler-Lenz M, Schweizer M, Ivics Z: Regulation for Gene and Cell Therapy Medicinal Products in Europe.
In: Terai S, Suda T (Hrsg.), Gene Therapy and Cell Therapy Through the Liver. Tokyo: Springer, 2016. S. 105-123, ISBN 978-4-431-55665-7

Sommer AFR, Rivière L, Qu B, Schott K, Riess M, Ni Y, Shepard C, Schnellbächer E, Finkernagel M, Himmelsbach K, Welzel K, Kettern N, Donnerhak C, Münk C, Flory E, Liese J, Kim B, Urban S, König R (2016): Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Sci Rep May 27 [Epub ahead of print].
Text

Celis P, Ferry N, Hystad M, Schüßler-Lenz M, Doevendans PA, Flory E, Beuneu C, Reischl I, Salmikangas P (2015): Advanced Therapy Medicinal Products: How to Bring Cell-Based Medicinal Products Successfully to the Market - Report from the CAT-DGTI-GSCN Workshop at the DGTI Annual Meeting 2014.
Transfus Med Hemother 42: 194-199.
Online-Abstract

Flory E, Gasparini P, Jekerle V, Palomäki T, Celis P, Boráň T, McBlane JW, Borg JJ, Kyselovic J, Lipnik–Stangelj M, Maimets T, Menezes-Ferreira M, Pante G, Prilla S, Riekstina U, Schneider CK, Tsiftsoglou A, Salmikangas P (2015): Regulatory viewpoints on the development of advanced stem cell–based medicinal products in light of the first EU-approved stem cell product.
Cell & Gene Therapy Insights 1: 109-127.
Online-Abstract

Salmikangas P, Menezes-Ferreira M, Reischl I, Tsiftsoglou A, Kyselovic J, Borg JJ, Ruiz S, Flory E, Trouvin JH, Celis P, Ancans J, Timon M, Pante G, Sladowski D, Lipnik-Stangelj M, Schneider CK (2015): Manufacturing, characterization and control of cell-based medicinal products: challenging paradigms toward commercial use.
Regen Med 10: 65-78.
Online-Abstract

Salmikangas P, Schuessler-Lenz M, Ruiz S, Celis P, Reischl I, Menezes-Ferreira M, Flory E, Renner M, Ferry N (2015): Marketing Regulatory Oversight of Advanced Therapy Medicinal Products (ATMPs) in Europe: The EMA/CAT Perspective.
Adv Exp Med Biol 871: 103-130.
Online-Abstract

Scherer J, Flory E (2015): Klassifizierung von zellbasierten Arzneimitteln und rechtliche Implikationen : Eine Übersicht und ein Update.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 58: 1201-1206.
Online-Abstract

Horn AV, Klawitter S, Held U, Berger A, Vasudevan AA, Bock A, Hofmann H, Hanschmann KM, Trösemeier JH, Flory E, Jabulowsky RA, Han J, Löwer J, Löwer R, Münk C, Schumann GG (2014): Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity.
Nucleic Acids Res 42: 396-416.
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Narayanan G, Cossu G, Galli MC, Flory E, Ovelgonne H, Salmikangas P, Schneider CK, Trouvin JH (2014): Clinical development of gene therapy needs a tailored approach: a regulatory perspective from the European Union.
Hum Gene Ther Clin Dev 25: 1-6.
Online-Abstract

Barkholt L, Flory E, Jekerle V, Lucas-Samuel S, Ahnert P, Bisset L, Büscher D, Fibbe W, Foussat A, Kwa M, Lantz O, Maciulaitis R, Palomäki T, Schneider CK, Sensebé L, Tachdjian G, Tarte K, Tosca L, Salmikangas P (2013): Risk of tumorigenicity in mesenchymal stromal cell-based therapies--bridging scientific observations and regulatory viewpoints.
Cytotherapy 15: 753-759.
Online-Abstract

Flory E, Reinhardt J (2013): European regulatory tools for advanced therapy medicinal products.
Transfus Med Hemother 40: 409-12.
Online-Abstract

Melchiorri D, Pani L, Gasparini P, Cossu G, Ancans J, Borg JJ, Drai C, Fiedor P, Flory E, Hudson I, Leufkens HG, Müller-Berghaus J, Narayanan G, Neugebauer B, Pokrotnieks J, Robert JL, Salmonson T, Schneider CK (2013): Regulatory evaluation of Glybera in Europe - two committees, one mission.
Nat Rev Drug Discov 12: 719.
Online-Abstract

Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT, Keppler OT (2012): SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Nat Med 18: 1682-1687.
Online-Abstract

Kopietz F, Jaguva Vasudevan AA, Krämer M, Muckenfuss H, Sanzenbacher R, Cichutek K, Flory E, Münk C (2012): Interaction of human immunodeficiency virus type 1 Vif with APOBEC3G is not dependent on serine/threonine phosphorylation status.
J Gen Virol 93: 2425-2430.
Online-Abstract

Berger A, Schüle S, Flory E (2011): Die Zertifizierung neuartiger Therapien : Ein Gütesiegel für die Produktentwicklung in kleinen und mittelständischen Unternehmen.
Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz 54: 816-821.
Volltext

Berger A, Sommer AFR, Zwarg J, Hamdorf M, Welzel K, Esly N, Panitz S, Reuter A, Ramos I, Jatiani A, Mulder LCF, Fernandez-Sesma A, Rutsch F, Simon V, König R, Flory E (2011): SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.
PLoS Pathog 7: e1002425.
Text

Hamdorf M, Berger A, Schüle S, Reinhardt J, Flory E (2011): PKCδ-induced PU.1 Phosphorylation Promotes Hematopoietic Stem Cell Differentiation to Dendritic Cells.
Stem Cells 29: 297-306.
Online-Abstract

Tschulena U, Sanzenbacher R, Mühlebach MD, Berger A, Münch J, Schindler M, Kirchhoff F, Plesker R, Coulibaly C, Panitz S, Prüfer S, Muckenfuss H, Hamdorf M, Schweitzer M, Cichutek K, Flory E (2011): Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease.
Retrovirology 8: 14.
Online-Abstract

Berger A, Münk C, Schweizer M, Cichutek K, Schüle S, Flory E (2010): Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes.
J Biol Chem 285: 12248-54.
Online-Abstract

Perkovic M, Norley S, Sanzenbacher R, Battenberg M, Panitz S, Coulibaly C, Flory E, Siegismund C, Münk C, Cichutek K (2010): SIVagm containing the SHIV89.6P Envelope gene replicates poorly and is non-pathogenic.
Virology 399: 87-97.
Online-Abstract

Salmikangas P, Flory E, Reinhardt J, Hinz T, Maciulaitis R (2010): Regulatory requirements for clinical trial and marketing authorisation application for cell-based medicinal products.
Bundesgesundheitsbl – Gesundheitsforsch – Gesundheitsschutz 53: 24-29.
Online-Abstract Text

Schneider CK, Salmikangas P, Jilma B, Flamion B, Todorova LR, Paphitou A, Haunerova I, Maimets T, Trouvin JH, Flory E, Tsiftsoglou A, Sarkadi B, Gudmundsson K, O'Donovan M, Migliaccio G, Ancans J, Maciulaitis R, Robert JL, Samuel A, Ovelgönne JH, Hystad M, Fal AM, Lima BS, Moraru AS, Turcáni P, Zorec R, Ruiz S, Akerblom L, Narayanan G, Kent A, Bignami F, Dickson JG, Niederwiseser D, Figuerola-Santos MA, Reischl IG, Beuneu C, Georgiev R, Vassiliou M, Pychova A, Clausen M, Methuen T, Lucas S, Schüssler-Lenz M, Kokkas V, Buzás Z, MacAleenan N, Galli MC, Line A, Gulbinovic J, Berchem G, Fraczek M, Menezes-Ferreira M, Vilceanu N, Hrubisko M, Marinko P, Timón M, Cheng W, Crosbie GA, Meade N, di Paola ML, VandenDiressche T, Ljungman P, D'Apote L, Oliver-Diaz O, Büttel I, Celis P (2010): Challenges with advanced therapy medicinal products and how to meet them.
Nat Rev Drug Discov 9: 195-201.
Online-Abstract

Montag T, Nicol SB, Schurig U, Heiden M, Huber H, Sanzenbacher R, Flory E, Schwanig M, Schneider CK (2008): Microbial safety of cell based medicinal products - what can we learn from cellular blood components?.
Clin Chem Lab Med 46: 963-965.
Online-Abstract

Montag T, Spreitzer I, Löschner B, Unkelbach U, Flory E, Sanzenbacher R, Schwanig M, Schneider CK (2007): Safety testing of cell-based medicinal products: Opportunities for the monocyte activation test for pyrogens.
ALTEX 24: 81-89.
Online-Abstract

Muckenfuss H, Cichutek K, Flory E (2007): Current Regulation of Advanced Therapy Medicinal Products in the European Union.
J Intern Biotechnology Law 4: 16-20.
Online-Abstract

Muckenfuss H, Kaiser JK, Krebil E, Battenberg M, Schwer C, Cichutek K, Münk C, Flory E (2007): Sp1 and Sp3 regulate basal transcription of the human APOBEC3G gene.
Nucleic Acids Res 35: 3784-3796.
Online-Abstract

Sanzenbacher R, Dwenger A, Schuessler-Lenz M, Cichutek K, Flory E (2007): European regulation tackles tissue engineering.
Nat Biotechnol 25: 1089-1091.

Taylor A, Akdis M, Joss A, Wenig R, Colonna M, Daigle I, Flory E, Blaser K, Akdis C (2007): IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1.
J Allergy Clin Immunol 120: 76-83.
Online-Abstract

Hamdorf M, Muckenfuss H, Tschulena U, Cichutek K, Flory E (2006): An inducible T7 RNA polymerase-dependent expression system for generation of small interfering RNAs.
Mol Biotechnol 33: 13-22.
Online-Abstract

Muckenfuss H, Hamdorf M, Held U, Perkovic M, Löwer J, Cichutek K, Flory E, Schumann GG, Münk C (2006): APOBEC3 proteins inhibit human LINE-1 retrotransposition.
J Biol Chem 281: 22161-22172.
Online-Abstract

Muckenfuss H, Sanzenbacher R, Hamdorf M, Tschulena U, Avots A, Cichutek K, Flory E (2006): Interleukin-2 induction by simian immunodeficiency virus involves MAP Kinase signalling but is independent on Calcineurin/NF-AT activity.
Mol Immunol 43: 1172-1182.
Online-Abstract

Neumann J, Stitz J, König R, Seibold E, Norley S, Flory E, Cichutek K (2006): Retroviral vectors for vaccine development: Induction of HIV-1-specific humoral and cellular immune responses in rhesus macaques using a novel MLV(HIV-1) pseudotype vector.
J Biotechnol 124: 615-625.
Online-Abstract

Löchelt M, Romen F, Bastone P, Muckenfuss H, Kirchner N, Kim YB, Truyen U, Rösler U, Battenberg M, Saib A, Flory E, Cichutek K, Münk C (2005): The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein.
Proc Natl Acad Sci Epub May 23; 102: 7982-7987.
Online-Abstract

Mühlebach MD, Wolfrum N, Schüle S, Tschulena U, Sanzenbacher R, Flory E, Cichutek K, Schweizer M (2005): Stable Transduction of Primary Human Monocytes by Simian Lentiviral Vector PBj.
Mol Ther 12: 1206-1216.

Cichutek K, Flory E, Seitz R, Heiden M (2002): Regulatorische Aspekte der Anwendung humaner Stammzellen.
Bundesgesundheitsbl – Gesundheitsforsch – Gesundheitsschutz 45: 108-112.
Online-Abstract Text

König RR, Flory E, Steidl S, Neumann J, Coulibaly C, Holznagel E, Holzammer S,, Norley S, Cichutek K (2002): Engineered CD4- and CXCR4-using simian immunodeficiency virus from African green monkeys is neutralization sensitive and replicates in nonstimulated lymphocytes.
J Virol 76: 10627-36.
Online-Abstract

Scheef G, Fischer N, Flory E, Schmitt I, Tönjes RR (2002): Transcriptional regulation of porcine endogenous retroviruses released from porcine and infected human cells by heterotrimeric protein complex NF-Y and impact of immunosuppressive drugs.
J Virol 76: 12553-12563.
Online-Abstract

Scheller C, Sopper S, Chen P, Flory E, Koutsilieri E, Racek T, Ludwig S, Meulen V, Jassoy C (2002): Caspase inhibition activates HIV in latently infected cells. Role of tumor necrosis factor receptor 1 and CD95.
J Biol Chem 277: 15459-64. Epub Feb. 19.
Online-Abstract

Scheller C, Sopper S, Ehrhardt C, Flory E, Chen P, Koutsilieri E, Ludwig S, Meulen V, Jassoy C (2002): Caspase inhibitors induce a switch from apoptotic to proinflammatory signaling in CD95-stimulated T lymphocytes.
Eur J Immunol 32: 2471-2480.
Online-Abstract

Steidl S, Stitz J, Schmitt I, König R, Flory E, Schweizer M, Cichutek K (2002): Coreceptor Switch of [MLV(SIVagm)] Pseudotype Vectors by V3-Loop exchange.
Virology Sep. 1; 300: 205-216.
Online-Abstract

Cichutek K, Schweizer M, Flory E, Buchholz CJ (2001): Regulatorische Aspekte der Anwendung von Gentransfer-Arzneimitteln in der Humanmedizin.
Bundesgesundheitsbl-Gesundheitsforsch-Gesundheitsschutz 44: 1083-1089.
Online-Abstract Volltext

Fischer TA, Ludwig S, Flory E, Gambaryan S, Krisna S, Peffer MA, Kelly RA, Pfeffer JM (2001): Activation of cardiac c-Jun NH2-terminal Kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load.
Hypertension 37: 1222-28.
Online-Abstract

Schweizer M, Flory E, Buchholz CJ, Cichutek K (2001): Retroviral Vectors.
Bundesgesundheitsbl-Gesundheitsforsch-Gesundheitsschutz 44: 1038-1046.
Online-Abstract Text

Flory E, Chen P, Avots A, Jordan BW, Kirchhoff F, Ludwig S, Rapp UR (2000): Transactivation of naturally occurring HIV-1 LTRs by the JNK signaling pathway: the MFNLP sequence introduces a novel binding site for AP-1 factors.
J Biol Chem 275: 20382-90.
Online-Abstract

Flory E, Kunz M, Scheller C, Jassoy C, Stauber R, Rapp UR, Ludwig S (2000): Influenza virus induced NF-kappaB dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkB-kinase.
J. Biol. Chem 275: 8307-14.
Online-Abstract

Hoffmeyer A, Grosse-Wilde A, Flory E, Neufeld E, Kunz M, Rapp UR, Ludwig S (1999): Different mitogen-activated protein kinase signalling pathways cooperate to regulate TNF-alpha gene expression in T lymphocytes.
J Biol Chem 274: 4319-4327.
Online-Abstract

Flory E, Weber C, Chen P, Hoffmeyer A, Jassoy C, Rapp UR (1998): Plasma membrane-targeted Raf Kinase Activates NF-kB and Human Immunodeficiency Virus -1 replication in T Lymphocytes.
J. Virol 72: 2788-2794.
Online-Abstract

Stühler A, Flory E, Wege H, Lassmann H, Wege H (1997): No Evidence for Quasispecies Populations during Persistence of the Coronavirus Mouse Hepatitis Virus JHM: Sequence Conservation within the Surface Glycoprotein Gene S in Lewis Rats.
Journal of General Virology 78: 747-756.
Online-Abstract

Flory E, Stühler A, Barac-Latas V, Lassmann H, Wege H (1995): Coronavirus Induced Encephalomyelitis: Balance between Protection and Immune Pathology Depends on the Immunization Schedule with Spike Protein S.
Journal of General Virology 76: 873-879.
Online-Abstract

Flory E, Pfleiderer M, Stühler A, Siddell SG, Wege H (1993): Induction of Protective Immunity against Coronavirus Induced Encephalomyelitis: Evidence for an Important Role of CD8+ T-Cells in Vivo.
European Journal of Immunology 23: 1757-1761.