Paul-Ehrlich-Institut

Publikationen Prof. Dr. Zoltán Ivics

Autorinnen und Autoren des Paul-Ehrlich-Instituts sind durch Fettdruck kenntlich gemacht. Wenn Online-Abstracts oder Volltexte zu den Publikationen verfügbar sind, so sind diese verlinkt.

PubMed - Publikationsliste (Autor Prof. Dr. Zoltán Ivics)

Ochmann MT, Ivics Z (2021): Jumping Ahead with Sleeping Beauty: Mechanistic Insights into Cut-and-Paste Transposition.
Viruses 13: 76.
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Amberger M, Ivics Z (2020): Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier than Ever: Refinement and Recent Innovations of the Sleeping Beauty Transposon System Enabling Novel, Nonviral Genetic Engineering Applications.
Bioessays Sep 16 [Epub ahead of print].
Online-Abstract

Brown RJP, Tegtmeyer B, Sheldon J, Khera T, Anggakusuma, Todt D, Vieyres G, Weller R, Joecks S, Zhang Y, Sake S, Bankwitz D, Welsch K, Ginkel C, Engelmann M, Gerold G, Steinmann E, Yuan Q, Ott M, Vondran FWR, Krey T, Ströh LJ, Miskey C, Ivics Z, Herder V, Baumgärtner W, Lauber C, Seifert M, Tarr AW, McClure CP, Randall G, Baktash Y, Ploss A, Thi VLD, Michailidis E, Saeed M, Verhoye L, Meuleman P, Goedecke N, Wirth D, Rice CM, Pietschmann T (2020): Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice.
Sci Adv Nov 4 [Epub ahead of print].
Online-Abstract

Gao B, Zong W, Miskey C, Ullah N, Diaby M, Chen C, Wang X, Ivics Z, Song C (2020): Intruder (DD38E), a recently evolved sibling family of DD34E/Tc1 transposons in animals.
Mob DNA 11: 32.
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Ivics Z, Amberger M, Zahn T, Hildt E (2020): Immuntherapien zur Behandlung der chronischen Hepatitis-B-Virusinfektion - eine Übersicht unter besonderer Berücksichtigung von CAR-T-Zellen.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Sep 29 [Epub ahead of print].
Online-Abstract

Ivics Z (2020): Potent CAR-T Cells Engineered With Sleeping Beauty Transposon Vectors Display a Central Memory Phenotype.
Gene Ther Mar 5 [Epub ahead of print].
Online-Abstract

Kesselring L, Miskey C, Zuliani C, Querques I, Kapitonov V, Laukó A, Fehér A, Palazzo A, Diem T, Lustig J, Sebe A, Wang Y, Dinnyés A, Izsvák Z, Barabas O, Ivics Z (2020): A single amino acid switch converts the Sleeping Beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.
Nucleic Acids Res 48: 316-331.
Online-Abstract

Kovač A, Miskey C, Menzel M, Grueso E, Gogol-Döring A, Ivics Z (2020): RNA-guided Retargeting of Sleeping Beauty Transposition in Human Cells.
Elife 9: e53868.
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Laidou S, Alanis-Lobato G, Pribyl J, Raskó T, Tichy B, Mikulasek K, Tsagiopoulou M, Oppelt J, Kastrinaki G, Lefaki M, Singh M, Zink A, Chondrogianni N, Psomopoulos F, Prigione A, Ivics Z, Pospisoilova S, Skladal P, Izsvák Z, Andrade-Navarro MA, Petrakis S (2020): Nuclear Inclusions of Pathogenic ataxin-1 Induce Oxidative Stress and Perturb the Protein Synthesis Machinery.
Redox Biol 32: 101458.
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Merker M, Wagner J, Kreyenberg H, Heim C, Moser LM, Wels WS, Bonig H, Ivics Z, Ullrich E, Klingebiel T, Bader P, Rettinger E (2020): ERBB2-CAR-Engineered Cytokine-Induced Killer Cells Exhibit Both CAR-Mediated and Innate Immunity Against High-Risk Rhabdomyosarcoma.
Front Immunol Oct 19 [Epub ahead of print].
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Shen D, Gao B, Miskey C, Chen C, Sang Y, Zong W, Wang S, Wang Y, Wang X, Ivics Z, Song C (2020): Multiple Invasions of Visitor, a DD41D Family of Tc1/mariner Transposons, throughout the Evolution of Vertebrates.
Genome Biol Evol Jun 30 [Epub ahead of print].
Online-Abstract

Cullmann K, Blokland KEC, Sebe A, Schenk F, Ivics Z, Heinz N, Modlich U (2019): Sustained and regulated gene expression by Tet-inducible "All-In-One" retroviral vectors containing the HNRPA2B1-CBX3 UCOE.
Biomaterials 192: 486-499.
Online-Abstract

Hernandez M, Recalde S, Garcia-Garcia L, Bezunartea J, Miskey C, Johnen S, Diarra S, Sebe A, Rodriguez-Madoz JR, Pouillot S, Marie C, Izsvák Z, Scherman D, Kropp M, Prosper F, Thumann G, Ivics Z, Garcia-Layana A, Fernandez-Robredo P (2019): Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization.
Mol Ther Methods Clin Dev 15: 403-417.
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Palazzo A, Lorusso P, Miskey C, Walisko O, Gerbino A, Marobbio CMT, Ivics Z, Marsano RM1 (2019): Transcriptionally promiscuous "blurry" promoters in Tc1/mariner transposons allow transcription in distantly related genomes.
Mob DNA 10: 13.
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Querques I, Mades A, Zuliani C, Miskey C, Alb M, Grueso E, Machwirth M, Rausch T, Einsele H, Ivics Z, Hudecek M, Barabas O (2019): A highly soluble Sleeping Beauty transposase improves control of gene insertion.
Nat Biotechnol 37: 1502-1512.
Online-Abstract

Sang Y, Gao B, Diaby M, Zong W, Chen C, Shen D, Wang S, Wang Y, Ivics Z, Song C (2019): Incomer, a DD36E family of Tc1/mariner transposons newly discovered in animals.
Mob DNA 10: 45.
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Scheuermann B, Diem T, Ivics Z, Andrade-Navarro MA (2019): Evolution-guided evaluation of the inverted terminal repeats of the synthetic transposon Sleeping Beauty.
Sci Rep 9: 1171.
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Schumann GG, Fuchs NV, Tristán-Ramos P, Sebe A, Ivics Z, Heras SR (2019): The impact of transposable element activity on therapeutically relevant human stem cells.
Mobile DNA 10.
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Clauss J, Obenaus M, Miskey C, Ivics Z, Izsvák Z, Uckert W, Bunse M (2018): Efficient Non-Viral T-Cell Engineering by Sleeping Beauty Minicircles Diminishing DNA Toxicity and miRNAs Silencing the Endogenous T-Cell Receptors.
Hum Gene Ther 29: 569-584.
Online-Abstract

Gasparics A, Kökény G, Fintha A, Bencs R, Mózes MM, Ágoston EI, Buday A, Ivics Z, Hamar P, Györffy B, Rosivall L, Sebe A (2018): Alterations in SCAI Expression during Cell Plasticity, Fibrosis and Cancer.
Pathol Oncol Res 24: 641-651.
Online-Abstract

Holstein M, Mesa-Nuñez C, Miskey C, Almarza E, Poletti V, Schmeer M, Grueso E, Ordóñez Flores JC, Kobelt D, Walther W, Aneja MK, Geiger J, Bonig HB, Izsvák Z, Schleef M, Rudolph C, Mavilio F, Bueren JA, Guenechea G, Ivics Z (2018): Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors.
Mol Ther 26: 1137-1153.
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Hudecek M, Ivics Z (2018): Non-viral therapeutic cell engineering with the Sleeping Beauty transposon system.
Curr Opin Genet Dev 52.
Online-Abstract

Pastor M, Johnen S, Harmening N, Quiviger M, Pailloux J, Kropp M, Walter P, Ivics Z, Izsvák Z, Thumann G, Scherman D, Marie C (2018): The Antibiotic-free pFAR4 Vector Paired with the Sleeping Beauty Transposon System Mediates Efficient Transgene Delivery in Human Cells.
Mol Ther Nucleic Acids 11: 57-67.
Online-Abstract

Abou-El-Enein M, Cathomen T, Ivics Z, June CH, Renner M, Schneider CK, Bauer G (2017): Human Genome Editing in the Clinic: New Challenges in Regulatory Benefit-Risk Assessment.
Cell Stem Cell 21: 427-430.
Online-Abstract

Elling U, Wimmer RA, Leibbrandt A, Burkard T, Michlits G, Leopoldi A, Micheler T, Abdeen D, Zhuk S, Aspalter IM, Handl C, Liebergesell J, Hubmann M, Husa AM, Kinzer M, Schuller N, Wetzel E, van de Loo N, Martinez JAZ, Estoppey D, Riedl R, Yang F, Fu B, Dechat T, Ivics Z, Agu CA, Bell O, Blaas D, Gerhardt H, Hoepfner D, Stark A, Penninger JM (2017): A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.
Nature 550: 114-118.
Online-Abstract

Hodge R, Narayanavari S, Izsvák Z, Ivics Z (2017): Wide Awake and Ready to Move: 20 Years of Non-Viral Therapeutic Genome Engineering with the Sleeping Beauty Transposon System.
Hum Gene Ther 28: 842-855.
Online-Abstract

Kawakami K, Largaespada DA, Ivics Z (2017): Transposons As Tools for Functional Genomics in Vertebrate Models.
Trends Genet 33: 784-801.
Online-Abstract

Kebriaei P, Izsvák Z, Narayanavari SA, Singh H, Ivics Z (2017): Gene Therapy with the Sleeping Beauty Transposon System.
Trends Genet 33: 852-870.
Online-Abstract

Monjezi R, Miskey C, Gogishvili T, Schleef M, Schmeer M, Einsele H, Ivics Z, Hudecek M (2017): Enhanced CAR T-cell engineering using non-viral Sleeping Beauty-transposition from minicircle vectors.
Leukemia 31: 186-194.
Online-Abstract

Narayanavari SA, Chilkunda SS, Ivics Z, Izsvák Z (2017): Sleeping Beauty transposition: from biology to applications.
Crit Rev Biochem Mol Biol 52: 18-44.
Online-Abstract

Wang Y, Pryputniewicz-Dobrinska D, Nagy EÉ, Kaufman CD, Singh M, Yant S, Wang J, Dalda A, Kay MA, Ivics Z, Izsvák Z (2017): Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.
Nucleic Acids Res 45: 311-326.
Online-Abstract

Abrusán G, Yant SR, Szilágyi A, Marsh JA, Mátés L, Izsvák Z, Barabás O, Ivics Z (2016): Structural Determinants of Sleeping Beauty Transposase Activity.
Mol Ther 24: 1369-1377.
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Alessio AP, Fili AE, Garrels W, Forcato DO, Olmos Nicotra MF, Liaudat AC, Bevacqua RJ, Savy V, Hiriart MI, Talluri TR, Owens JB, Ivics Z, Salamone DF, Moisyadi S, Kues WA, Bosch P (2016): Establishment of cell-based transposon-mediated transgenesis in cattle.
Theriogenology 85: 1297-1311.
Online-Abstract

Friedel T, Jung-Klawitter S, Sebe A, Schenk F, Modlich U, Ivics Z, Schumann GG, Buchholz CJ, Schneider IC (2016): CD30 receptor-targeted lentiviral vectors for human induced pluripotent stem cell-specific gene modification.
Stem Cells Dev 25: 729-739.
Online-Abstract

Garrels W, Mukherjee A, Holler S, Cleve N, Talluri TR, Barg-Kues B, Diederich M, Köhler P, Petersen B, Lucas-Hahn A, Niemann H, Izsvák Z, Ivics Z, Kues WA (2016): Identification and re-addressing of a transcriptionally permissive locus in the porcine genome.
Transgenic Res 25: 63-70.
Online-Abstract

Garrels W, Talluri TR, Apfelbaum R, Carratalá YP, Bosch P, Pötzsch K, Grueso E, Ivics Z, Kues WA (2016): One-step Multiplex Transgenesis via Sleeping Beauty Transposition in Cattle.
Sci Rep 6: 21953.
Online-Abstract

Garrels W, Talluri TR, Ziegler M, Most I, Forcato DO, Schmeer M, Schleef M, Ivics Z, Kues W (2016): Cytoplasmic injection of murine zygotes with Sleeping Beauty transposon plasmids and minicircles results in the efficient generation of germline transgenic mice.
Biotechnol J 11: 178-184.
Online-Abstract

Gogol-Döring A, Ammar I, Gupta S, Bunse M, Miskey C, Chen W, Uckert W, Schulz TF, Izsvák Z, Ivics Z (2016): Genome-Wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4+ T Cells.
Mol Ther 24: 592-606.
Online-Abstract

Grabundzija I, Messing SA, Thomas J, Cosby RL, Bilic I, Miskey C, Gogol-Döring A, Kapitonov V, Gerhardt DJ, Diem T, Dalda A, Jurka J, Pritham EJ, Dyda F, Izsvák Z, Ivics Z (2016): A Helitron Transposon Resurrected From the Bat Genome Reveals a Novel Mechanism of Genome Shuffling in Eukaryotes.
Nat Commun 7: 10716.
Online-Abstract

Hoffmann OI, Kerekes A, Lipták N, Hiripi L, Bodo S, Szaloki G, Klein S, Ivics Z, Kues WA, Bosze Z (2016): Transposon-Based Reporter Marking Provides Functional Evidence for Intercellular Bridges in the Male Germline of Rabbits.
PLOS ONE 11: e0154489.
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Ivics Z (2016): Endogenous Transposase Source in Human Cells Mobilizes piggyBac Transposons.
Mol Ther 24: 851-854.
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Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Canadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG (2016): Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Nat Commun 7: 10286.
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Mukherjee A, Garrels W, Talluri TR, Tiedemann D, Bősze Z, Ivics Z, Kues WA (2016): Expression of Active Fluorophore Proteins in the Milk of Transgenic Pigs Bypassing the Secretory Pathway.
Sci Rep 6: 24464.
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Renner M, Anliker B, Flory E, Scherer J, Schüßler-Lenz M, Schweizer M, Ivics Z: Regulation for Gene and Cell Therapy Medicinal Products in Europe.
In: Terai S, Suda T (Hrsg.), Gene Therapy and Cell Therapy Through the Liver. Tokyo: Springer, 2016. S. 105-123, ISBN 978-4-431-55665-7

Sebe A, Ivics Z (2016): Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells with Sleeping Beauty Transposon-Based Stable Gene Delivery.
Methods Mol Biol 1400: 419-427.
Online-Abstract

Voigt F, Wiedemann L, Zuliani C, Querques I, Sebe A, Mátés L, Izsvák Z, Ivics Z, Barabas O (2016): Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
Nat Commun 7: 11126.
Online-Abstract

Wang J, Singh M, Sun C, Besser D, Prigione A, Ivics Z, Hurst LD, Izsvák Z (2016): Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Nat Protoc 11: 327-346.
Online-Abstract

Grandi FC, Rosser JM, Newkirk SJ, Yin J, Jiang X, Xing Z, Whitmore L, Bashir S, Ivics Z, Izsvák Z, Ye P, Yu YE, An W (2015): Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.
Genome Res 25: 1135-1146.
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Ivics Z, Izsvák Z (2015): Sleeping Beauty Transposition.
Microbiol Spectr 3: MDNA3-0042-2014.
Online-Abstract

Ivics Z (2015): Self-Destruct Genetic Switch to Safeguard iPS Cells.
Mol Ther 23: 1417-1420.
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Sturm A, Ivics Z, Vellai T (2015): The mechanism of ageing: primary role of transposable elements in genome disintegration.
Cell Mol Life Sci 72: 1839-1847.
Online-Abstract

Talluri TR, Kumar D, Glage S, Garrels W, Ivics Z, Debowski K, Behr R, Niemann H, Kues WA (2015): Derivation and Characterization of Bovine Induced Pluripotent Stem Cells by Transposon-Mediated Reprogramming.
Cell Reprogram 17: 131-140.
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Garrels W, Holler S, Taylor U, Herrmann D, Niemann H, Ivics Z, Kues WA (2014): Assessment of fetal cell chimerism in transgenic pig lines generated by Sleeping beauty transposition.
PLoS One 9: e96673.
Online-Abstract

Ivics Z, Garrels W, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Kues WA, Izsvák Z (2014): Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons.
Nat Protoc 9: 810-827.
Online-Abstract

Ivics Z, Hiripi L, Hoffmann OI, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Bösze Z, Izsvák Z (2014): Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons.
Nat Protoc 9: 794-809.
Online-Abstract

Ivics Z, Mátés L, Yau TY, Landa V, Zidek V, Bashir S, Hoffmann OI, Hiripi L, Garrels W, Kues WA, Bösze Z, Geurts A, Pravenec M, Rülicke T, Izsvák Z (2014): Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons.
Nat Protoc 9: 773-793.
Online-Abstract

Kolacsek O, Erdei Z, Apáti A, Sándor S, Izsvák Z, Ivics Z, Sarkadi B, Orbán TI (2014): Excision efficiency is not strongly coupled to transgenic rate: cell type-dependent transposition efficiency of sleeping beauty and piggyBac DNA transposons.
Hum Gene Ther Methods 25: 241-252.
Online-Abstract

Talluri TR, Kumar D, Glage S, Garrels W, Ivics Z, Debowski K, Behr R, Kues WA (2014): Non-viral reprogramming of fibroblasts into induced pluripotent stem cells by Sleeping Beauty and piggyBac transposons.
Biochem Biophys Res Commun 450: 581-587.
Online-Abstract

Turchiano G, Latella MC, Gogol-Döring A, Cattoglio C, Mavilio F, Izsvák Z, Ivics Z, Recchia A (2014): Genomic analysis of Sleeping Beauty transposon integration in human somatic cells.
PLoS One 9: e112712.
Online-Abstract

Wang Y, Wang J, Devaraj A, Singh M, Jimenez Orgaz A, Chen JX, Selbach M, Ivics Z, Izsvák Z (2014): Suicidal autointegration of sleeping beauty and piggyBac transposons in eukaryotic cells.
PLoS Genet 10: e1004103.
Online-Abstract

Wang J, Xie G, Singh M, Ghanbarian AT, Raskó T, Szvetnik A, Cai H, Besser D, Prigione A, Fuchs NV, Schumann GG, Chen W, Lorincz MC, Ivics Z, Hurst LD, Izsvák Z (2014): Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Nature 516: 405-409.
Online-Abstract

Grabundzija I, Wang J, Sebe A, Erdei Z, Kajdi R, Devaraj A, Steinemann D, Szuhai K, Stein U, Cantz T, Schambach A, Baum C, Izsvák Z, Sarkadi B, Ivics Z (2013): Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells.
Nucleic Acids Res 41: 1829-1847.
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Hozumi A, Mita K, Miskey C, Mates L, Izsvak Z, Ivics Z, Satake H, Sasakura Y (2013): Germline transgenesis of the chordate Ciona intestinalis with hyperactive variants of sleeping beauty transposable element.
Dev Dyn 242: 30-43.
Online-Abstract

Jursch T, Miskey C, Izsvák Z, Ivics Z (2013): Regulation of DNA transposition by CpG methylation and chromatin structure in human cells.
Mob DNA 4: 15.
Online-Abstract

Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, Grzybowski M, Corbett M, Filho AR, Hodges MR, Bader M, Ivics Z, Jacob HJ, Pravenec M, Bosze Z, Rülicke T, Izsvák Z (2013): Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.
FASEB J 27: 930-941.
Online-Abstract

Kues WA, Herrmann D, Barg-Kues B, Haridoss S, Nowak-Imialek M, Buchholz T, Streeck M, Grebe A, Grabundzija I, Merkert S, Martin U, Hall VJ, Rasmussen MA, Ivics Z, Hyttel P, Niemann H (2013): Derivation and characterization of sleeping beauty transposon-mediated porcine induced pluripotent stem cells.
Stem Cells Dev 22: 124-135.
Online-Abstract

Molina-Estevez FJ, Lozano ML, Navarro S, Torres Y, Grabundzija I, Ivics Z, Samper E, Bueren JA, Guenechea G (2013): Brief report: impaired cell reprogramming in nonhomologous end joining deficient cells.
Stem Cells 31: 1726-1730.
Online-Abstract

Palazzo A, Marconi S, Specchia V, Bozzetti MP, Ivics Z, Caizzi R, Marsano RM (2013): Functional characterization of the Bari1 transposition system.
PLoS One 8: e79385.
Online-Abstract

Xie Y, Mates L, Ivics Z, Izsvák Z, Martin SL, An W (2013): Cell division promotes efficient retrotransposition in a stable L1 reporter cell line.
Mob DNA 4: 10.
Online-Abstract

Zhang W, Muck-Hausl M, Wang J, Sun C, Gebbing M, Miskey C, Ivics Z, Izsvak Z, Ehrhardt A (2013): Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive sleeping beauty transposase for somatic integration.
PLoS One 8: e75344.
Online-Abstract

Ammar I, Izsvák Z, Ivics Z (2012): The Sleeping Beauty transposon toolbox.
Methods Mol Biol 859: 229-240.
Online-Abstract

Ammar I, Gogol-Döring A, Miskey C, Chen W, Cathomen T, Izsvák Z, Ivics Z (2012): Retargeting transposon insertions by the adeno-associated virus Rep protein.
Nucleic Acids Res 40: 6693-6712.
Online-Abstract

Garrels W, Ivics Z, Kues WA (2012): Precision genetic engineering in large mammals.
Trends Biotechnol 30: 386-393.
Online-Abstract

Izsvak Z, Ivics Z: Sleeping Beauty transposon based gene therapy.
In: Cohen-Hagenauer O (Hrsg.), Clinical Gene Transfer - State Of The Art (The CliniBook). Paris: EDK, 2012. S. 284-289

Muenthaisong S, Ujhelly O, Polgar Z, Varga E, Ivics Z, Pirity MK, Dinnyes A (2012): Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping beauty transposon mediated gene transfer.
Exp Cell Res 318: 2482-2489.
Online-Abstract

Petrakis S, Raskó T, Mátés L, Ivics Z, Izsvák Z, Kouzi-Koliakou K, Koliakos G (2012): Gateway-compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells.
Biotechnol J 7: 891-897.
Online-Abstract

Swierczek M, Izsvák Z, Ivics Z (2012): The Sleeping Beauty transposon system for clinical applications.
Expert Opin Biol Ther 12: 139-153.
Online-Abstract

Voigt K, Gogol-Döring A, Miskey C, Chen W, Cathomen T, Izsvák Z, Ivics Z (2012): Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains.
Mol Ther 20: 1852-1862.
Online-Abstract

Galla M, Schambach A, Falk CS, Maetzig T, Kuehle J, Lange K, Zychlinski D, Heinz N, Brugman MH, Göhring G, Izsvák Z, Ivics Z, Baum C (2011): Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery.
Nucleic Acids Res 39: 7147-7160.
Online-Abstract

Garrels W, Holler S, Taylor U, Herrmann D, Struckmann C, Klein S, Barg-Kues B, Nowak-Imialek M, Ehling C, Rath D, Ivics Z, Niemann H, Kues WA (2011): Genotype-independent transmission of transgenic fluorophore protein by boar spermatozoa.
PLoS One 6: e27563.
Online-Abstract

Garrels W, Mátés L, Holler S, Dalda A, Taylor U, Petersen B, Niemann H, Izsvák Z, Ivics Z, Kues WA (2011): Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome.
PLoS One 6: e23573.
Online-Abstract

Grabundzija I, Izsvák Z, Ivics Z (2011): Insertional engineering of chromosomes with Sleeping Beauty transposition: an overview.
Methods Mol Biol 738: 69-85.
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Ivics Z, Izsvák Z, Chapman KM, Hamra FK (2011): Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells.
Methods 53: 356-365.
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Ivics Z, Izsvák Z (2011): Nonviral gene delivery with the sleeping beauty transposon system.
Hum Gene Ther 22: 1043-1051.
Online-Abstract

Ivics Z, Izsvák Z, Medrano G, Chapman KM, Hamra FK (2011): Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells.
Nat Protoc 6: 1521-1535.
Online-Abstract

Jin Z, Maiti S, Huls H, Singh H, Olivares S, Mátés L, Izsvák Z, Ivics Z, Lee DA, Champlin RE, Cooper LJN (2011): The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor.
Gene Ther 18: 849-856.
Online-Abstract

Kolacsek O, Krízsik V, Schamberger A, Erdei Z, Apáti A, Várady G, Mátés L, Izsvák Z, Ivics Z, Sarkadi B, Orbán TI (2011): Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers.
Mob DNA 2: 5.
Online-Abstract

Moldt B, Miskey C, Staunstrup NH, Gogol-Döring A, Bak RO, Sharma N, Mátés L, Izsvák Z, Chen W, Ivics Z, Mikkelsen JG (2011): Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells.
Mol Ther 19: 1499-1510.
Online-Abstract

Albieri I, Onorati M, Calabrese G, Moiana A, Biasci D, Badaloni A, Camnasio S, Spiliotopoulos D, Ivics Z, Cattaneo E, Consalez GG (2010): A DNA transposon-based approach to functional screening in neural stem cells.
J Biotechnol 150: 11-21.
Online-Abstract

Belay E, Mátrai J, Acosta-Sanchez A, Ma L, Quatrocelli M, Mátés L, Sancho-Bru P, Geraerts M, Yan B, Vermeesch J, Rincón MY, Samara-Kuko E, Ivics Z, Verfaillie C, Sampaolesi M, Izsvák Z, Vandendriessche T, Chuah MK (2010): Novel hyperactive transposons for genetic modification of induced pluripotent and adult stem cells: a nonviral paradigm for coaxed differentiation.
Stem Cells 28: 1760-1771.
Online-Abstract

de Silva S, Mastrangelo MA, Lotta Jr LT, Burris CA, Izsvák Z, Ivics Z, Bowers WJ (2010): Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo.
Hum Gene Ther 21: 1603-1613.
Online-Abstract

Grabundzija I, Irgang M, Mátés L, Belay E, Matrai J, Gogol-Döring A, Kawakami K, Chen W, Ruiz P, Chuah MK, VandenDriessche T, Izsvák Z, Ivics Z (2010): Comparative analysis of transposable element vector systems in human cells.
Mol Ther 18: 1200-1209.
Online-Abstract

Ivics Z, Izsvák Z (2010): The expanding universe of transposon technologies for gene and cell engineering.
Mob DNA 1: 25.
Online-Abstract

Ivics Z, Izsvák Z (2010): Repetitive elements and genome instability.
Semin Cancer Biol 20: 197-199.

Izsvák Z, Fröhlich J, Grabundzija I, Shirley JR, Powell HM, Chapman KM, Ivics Z, Hamra FK (2010): Generating knockout rats by transposon mutagenesis in spermatogonial stem cells.
Nat Methods 7: 443-445.
Online-Abstract

Izsvák Z, Hackett PB, Cooper LJ, Ivics Z (2010): Translating Sleeping Beauty transposition into cellular therapies: victories and challenges.
Bioessays 32: 756-767.
Online-Abstract

Kuzmin D, Gogvadze E, Kholodenko R, Grzela DP, Mityaev M, Vinogradova T, Kopantzev E, Malakhova G, Suntsova M, Sokov D, Ivics Z, Buzdin A (2010): Novel strong tissue specific promoter for gene expression in human germ cells.
BMC Biotechnol 10: 58.
Online-Abstract

Schebelle L, Wolf C, Striebl C, Javaheri T, Schnütgen F, Ettinger A, Ivics Z, Hansen J, Ruiz P, von Melchner H, Wurst W, Floss T (2010): Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.
Nucleic Acids Res 38: e106.
Online-Abstract

Wang Y, Liska F, Gosele C, Sedová L, Kren V, Krenová D, Ivics Z, Hubner N, Izsvák Z (2010): A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.
Genome Res 20: 19-27.
Online-Abstract

Schumann GG, Gogvadze EV, Osanai-Futahashi M, Kuroki A, Münk C, Fujiwara H, Ivics Z, Buzdin AA (2010): Unique functions of repetitive transcriptomes.
Int Rev Cell Mol Biol 285: 115-188.
Online-Abstract

Ivics Z (2009): Genomic parasites and genome evolution.
Genome Biol 10: 306.
Online-Abstract

Ivics Z, Li MA, Mátés L, Boeke JD, Nagy A, Bradley A, Izsvák Z (2009): Transposon-mediated genome manipulation in vertebrates.
Nat Methods 6: 415-422.
Online-Abstract

Izsvák Z, Chuah MK, VandenDriessche T, Ivics Z (2009): Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors.
Methods 49: 287-297.
Online-Abstract

Izsvák Z, Wang Y, Ivics Z: Interactions of transposons with the cellular DNA repair machinery.
In: Lankenau DH, Volff JN (Hrsg.), Transposons and the Dynamic Genome Berlin u.a.: Springer, 2009. 133-176
(Genome Dynamics and Stability; 4)

Mátés L, Chua MK, Belay E, Jerchow B, Manoj N, Acosta-Sanchez A, Grzela DP, Schmitt A, Becker K, Matrai J, Ma L, Samara-Kuko E, Gysemans C, Pryputniewicz D, Miskey C, Fletcher B, VandenDriessche T, Ivics Z, Izsvák Z (2009): Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates.
Mol Genet 41: 753-761.
Online-Abstract

Ohlfest JR, Ivics Z, Izsvák Z (2009): Transposable elements as plasmid-based vectors for long-term gene transfer into tumors.
Methods Mol Biol 542: 105-116.
Online-Abstract

Orbán TI, Apáti Á, Németh A, Varga N, Krizsik V, Schamberger A, Szebényi K, Erdei Z, Várady G, Karászi É, Homolya L, Német K, Gócza E, Miskey C, Mátés L, Ivics Z, Izsvák Z, Sarkadi B (2009): Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery.
Stem Cells 27: 1077-1087.
Online-Abstract

Sinzelle L, Izsvák Z, Ivics Z (2009): Molecular domestication of transposable elements: from detrimental parasites to useful host genes.
Cell Mol Life Sci 66: 1073-1093.
Online-Abstract

Staunstrup NH, Moldt B, Mátés L, Villesen P, Jakobsen M, Ivics Z, Izsvák Z, Mikkelsen JG (2009): Hybrid lentivirus-transposon vectors with a random integration profile in human cells.
Mol Ther 17: 1205-1214.
Online-Abstract

VandenDriessche T, Ivics Z, Izsvák Z, Chuah MK (2009): Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells.
Blood 114: 1461-1468.
Online-Abstract

Walisko O, Jursch T, Izsvák Z, Ivics Z: Transposon–Host Cell Interactions in the Regulation of Sleeping Beauty Transposition.
In: Lankenau DH, Volff JN (Hrsg.), Transposons and the Dynamic Genome Berlin u.a.: Springer, 2009. 109-132
(Genome Dynamics and Stability; 4)

Xue X, Huang X, Nodland SE, Mátés L, Ma L, Izsvák Z, Ivics Z, LeBien TW, McIvor RS, Wagner JE, Zhou Z (2009): Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.
Blood 114: 1319-1330.
Online-Abstract

Sinzelle L, Kapitonov VV, Grzela DP, Jursch T, Jurka J, Izsvák Z, Ivics Z (2008): Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes.
Proc Natl Acad Sci U S A 105: 4715-4720.
Online-Abstract

Voigt K, Izsvák Z, Ivics Z (2008): Targeted gene insertion for molecular medicine.
J Mol Med (Berl) 86: 1205-1219.
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Walisko O, Schorn A, Rolfs F, Devaraj A, Miskey C, Izsvák Z, Ivics Z (2008): Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators.
Mol Ther 16: 359-369.
Online-Abstract

Ivics Z, Katzer A, Stüwe EE, Fiedler D, Knespel S, Izsvák Z (2007): Targeted Sleeping Beauty transposition in human cells.
Mol Ther 15: 1137-1144.
Online-Abstract

Mátés L, Izsvák Z, Ivics Z (2007): Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives.
Genome Biol 8: S1.
Online-Abstract

Miskey C, Papp B, Mátés L, Sinzelle L, Keller H, Izsvák Z, Ivics Z (2007): The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends.
Mol Cell Biol 27: 4589-4600.
Online-Abstract

Takeda J, Izsvák Z, Ivics Z: Insertional mutagenesis of the mouse germline with Sleeping Beauty transposition.
In: Davis GD, Kayser KJ (Hrsg.), Chromosomal mutagenesis, 2007. 109-125
(Methods Mol Biol; 435)

Ivics Z, Izsvák Z (2006): Transposons for gene therapy!.
Curr Gene Ther 6: 593-607.
Online-Abstract

Izsvák Z, Ivics Z, Mátés L (2006): Hungary's 'reforms' are threatening basic science.
Nature 443: 394.

Walisko O, Ivics Z (2006): Interference with cell cycle progression by parasitic genetic elements: sleeping beauty joins the club.
Cell Cycle 5: 1275-1280.
Online-Abstract

Walisko O, Izsvák Z, Szabó K, Kaufman CD, Herold S, Ivics Z (2006): Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1.
Proc Natl Acad Sci U S A 103: 4062-4067.
Online-Abstract

Ivics Z, Izsvák Z (2005): A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.
Trends Genet 21: 8-11.
Online-Abstract

Izsvák Z, Ivics Z (2005): Sleeping Beauty hits them all: transposon-mediated saturation mutagenesis in the mouse germline.
Nat Methods 2: 735-736.

Kaufman CD, Izsvák Z, Katzer A, Ivics Z (2005): Frog Prince transposon-based RNAi vectors mediate efficient gene knockdown in human cells.
J RNAi Gene Silencing 1: 97-104.
Online-Abstract

Miskey C, Izsvák Z, Kawakami K, Ivics Z (2005): DNA transposons in vertebrate functional genomics.
Cell Mol Life Sci 62: 629-641.
Online-Abstract

Ivics Z, Kaufman CD, Zayed H, Miskey C, Walisko O, Izsvák Z (2004): The Sleeping Beauty transposable element: evolution, regulation and genetic applications.
Curr Issues Mol Biol 6: 43-56.

Izsvák Z, Ivics Z (2004): Sleeping beauty transposition: biology and applications for molecular therapy.
Mol Ther 9: 147-156.
Online-Abstract

Izsvák Z, Stüwe EE, Fiedler D, Katzer A, Jeggo PA, Ivics Z (2004): Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells.
Mol Cell 13: 279-290.
Online-Abstract

Zayed H, Izsvák Z, Walisko O, Ivics Z (2004): Development of hyperactive sleeping beauty transposon vectors by mutational analysis.
Mol Ther 9: 292-304.
Online-Abstract

Miskey C, Izsvák Z, Plasterk RH, Ivics Z (2003): The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells.
Nucleic Acids Res 31: 6873-6881.
Online-Abstract

Zayed H, Izsvák Z, Khare D, Heinemann U, Ivics Z (2003): The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition.
Nucleic Acids Res 31: 2313-2322.
Online-Abstract

Izsvák Z, Khare D, Behlke J, Heinemann U, Plasterk RH, Ivics Z (2002): Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition.
J Biol Chem 277: 34581-34588.
Online-Abstract

Vigdal T, Kaufman C, Izsvák Z, Voytas D, Ivics Z (2002): Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements.
J Mol Biol 323: 441-452.
Online-Abstract

Izsvák Z, Ivics Z, Plasterk RH (2000): Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates.
J Mol Biol 302: 93-102.
Online-Abstract

Yant SR, Meuse L, Chiu W, Ivics Z, Izsvák Z, Kay MA (2000): Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system.
Nat Genet 25: 35-41.
Online-Abstract

Hackett PB, Izsvák Z, Ivics Z, Caldovic L: Development of genetic tools for transgenic animals.
In: Murray JD, Anderson GB, McGloughlin MM, Oberbauer AM (Hrsg.), Transgenic Animals in Agriculture Wallingford, UK: CAB International, 1999. 19-35

Ivics Z, Izsvák Z, Heckett PB (1999): Genetic applications of transposons and other repetitive elements in zebrafish.
Methods Cell Biol 60: 99-131.

Izsvák Z, Ivics Z, Shimoda N, Mohn D, Okamoto H, Hackett PB (1999): Short inverted-repeat transposable elements in teleost fish and implications for a mechanism of their amplification.
J Mol Evol 48: 13-21.
Online-Abstract

Plasterk RH, Izsvák Z, Ivics Z (1999): Resident aliens: the Tc1/mariner superfamily of transposable elements.
Trends Genet 15: 326-332.
Online-Abstract

Luo G, Ivics Z, Izsvák Z, Bradley A (1998): Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells.
Proc Natl Acad Sci U S A 95: 10769-10773.
Online-Abstract

Plasterk RH, Van Luenen H, Vos C, Ivics Z, Izsvák Z, Fischer S (1998): Transposable elements as tools from mutagenesis and transgenesis of vertebrates.
Pathol Biol (Paris) 46: 674-675.
Online-Abstract

Ivics Z, Hackett PB, Plasterk RH, Izsvák Z (1997): Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells.
Cell 91: 501-510.
Online-Abstract

Ivics Z, Izsvák Z (1997): Family of plasmid vectors for the expression of beta-galactosidase fusion proteins in eukaryotic cells.
Biotechniques 22: 254-256; 258.
Online-Abstract

Izsvák Z, Ivics Z, Hackett PB (1997): Repetitive elements and their genetic applications in zebrafish.
Biochem Cell Biol 75: 507-523.
Online-Abstract

Ivics Z, Izsvák Z, Minter A, Hackett PB (1996): Identification of functional domains and evolution of Tc1-like transposable elements.
Proc Natl Acad Sci U S A 93: 5008-5013.
Online-Abstract

Izsvák Z, Ivics Z, Garcia-Estefania D, Fahrenkrug SC, Hackett PB (1996): DANA elements: a family of composite, tRNA-derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio).
Proc Natl Acad Sci U S A 93: 1077-1081.
Online-Abstract

Ivics Z, Izsvák Z, Hackett PB (1995): Repeated sequence elements in zebrafish and their use in molecular genetic studies.
Zebrafish Science Monitor 3: 1-4.

Izsvák Z, Ivics Z, Hackett PB (1995): Characterization of a Tc1-like transposable element in zebrafish (Danio rerio).
Mol Gen Genet 247: 312-322.
Online-Abstract

Ivics Z, Izsvák Z, Hackett PB (1993): Enhanced incorporation of transgenic DNA into zebrafish chromosomes by a retroviral integration protein.
Mol Mar Biol Biotechnol 2: 162-173.
Online-Abstract

Izsvák Z, Ivics Z (1993): Two-stage ligation-mediated PCR enhances the detection of integrated transgenic DNA.
Biotechniques 15: 814-818.
Online-Abstract

Müller F, Ivics Z, Erdélyi F, Papp T, Váradi L, Horváth L, Maclean N, Orbán L (1992): Introducing foreign genes into fish eggs with electroporated sperm as a carrier.
Mol Mar Biol Biotechnol 1: 276-281.
Online-Abstract