Autorinnen und Autoren des Paul-Ehrlich-Instituts sind durch Fettdruck kenntlich gemacht. Wenn Online-Abstracts oder Volltexte zu den Publikationen verfügbar sind, so sind diese verlinkt.
Schüssler M, Schott K, Fuchs NV, Oo A, Zahadi M, Rauch P, Kim B, König R (2023): Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels.
mBio 14: e0225223.
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Schott K, Majer C, Bulashevska A, Childs L, Schmidt MHH, Rajalingam K, Munder M, König R (2022): SAMHD1 in cancer: curse or cure?.
J Mol Med (Berl) 100: 351-372.
Online-Abstract
Yoh SM, Mamede JI, Lau D, Ahn N, Sánchez-Aparicio MT, Temple J, Tuckwell A, Fuchs NV, Cianci GC, Riva L, Curry H, Yin X, Gambut S, Simons LM, Hultquist JF, König R, Xiong Y, García-Sastre A, Böcking T, Hope TJ, Chanda SK (2022): Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA.
Mol Cell 82: 2871-2884.e6.
Online-Abstract
Bitar L, Schumann U, König R, Zipp F, Schmidt MHH (2021): Targeting Immune Modulators in Glioma While Avoiding Autoimmune Conditions.
Cancers (Basel) 13: 3524.
Online-Abstract
Canet-Pons J, Sen NE, Arsovíc A, Almaguer-Mederos LE, Halbach MV, Key J, Döring C, Kerksiek A, Picchiarelli G, Cassel R, René F, Dieterlé S, Fuchs NV, König R, Dupuis L, Lütjohann D, Gispert S, Auburger G (2021): Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression.
Neurobiol Dis 152: 105289.
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König R, Münk C (2021): Special Issue: 'Innate Immune Sensing of Viruses and Viral Evasion'.
Viruses 13: 567.
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Fuchs NV, Schieck M, Neuenkirch M, Tondera C, Schmitz H, Steinemann D, Göhring G, König R (2020): Induced pluripotent stem cell line (PEIi003-A) derived from an apparently healthy male individual.
Stem Cell Res 42: 101679.
Online-Abstract
Fuchs NV, Schieck M, Neuenkirch M, Tondera C, Schmitz H, Wendeburg L, Steinemann D, Elpers C, Rutsch F, König R (2020): Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi-Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1).
Stem Cell Res 43: 101697.
Online-Abstract
Karamloo F, König R (2020): SARS-CoV-2 immunogenicity at the crossroads.
Allergy 75: 1822-1824.
Online-Abstract
Lauterbach-Rivière L, Bergez M, Mönch S, Qu B, Riess M, Vondran FWR, Liese J, Hornung V, Urban S, König R (2020): Hepatitis B Virus DNA Is a Substrate for the cGAS/STING Pathway but Is Not Sensed in Infected Hepatocytes.
Viruses 12: E592.
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Patasic L, Seifried J, Bezler V, Kaljanac M, Schneider IC, Schmitz H, Tondera C, Hartmann J, Hombach A, Buchholz CJ, Abken H, König R, Cichutek K (2020): Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4 + T cells to reduce the latent HIV + cell reservoir.
Med Microbiol Immunol 209: 681-691.
Online-Abstract
Yin X, Langer S, Zhang Z, Herbert KM, Yoh S, König R, Chanda SK (2020): Sensor Sensibility-HIV-1 and the Innate Immune Response.
Cells 9: 254.
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Bergez M, Weber J, Riess M, Erdbeer A, Seifried J, Stanke N, Munz C, Hornung V, König R , Lindemann D (2019): Insights into Innate Sensing of Prototype Foamy Viruses in Myeloid Cells.
Viruses 11: 1095.
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Crauwels P, Bank E, Walber B, Wenzel UA, Agerberth B, Negatue MC, Alemayehu MA, König R, Ritter U, Reiling N, van Zandbergen G (2019): Cathelicidin mediated elimination of Leishmania in human host macrophages.
Front Immunol 10: 2697.
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Fuchs NV, Schieck M, Neuenkirch M, Tondera C, Schmitz H, des Portes V, Germanaud D, Steinemann D, Göhring G, König R (2019): Induced pluripotent stem cells (iPSCs) derived from a renpenning syndrome patient with c.459_462delAGAG mutation in PQBP1 (PEIi001-A).
Stem Cell Res 41: 101592.
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Majer C, Schüssler JM, König R (2019): Intertwined: SAMHD1 cellular functions, restriction, and viral evasion strategies.
Med Microbiol Immunol 208: 513-529.
Online-Abstract
Osei Kuffour E, König R, Häussinger D, Schulz WA, Münk C (2019): ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
MBio 10: e01342-19.
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König R (2018): Virulence Profile: Renate König.
Virulence 9: 278-280.
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Osei Kuffour E, Schott K, Jaguva Vasudevan AA, Holler J, Schulz WA, Lang PA, Lang KS, Kim B, Häussinger D, König R, Münk C (2018): USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.
J Virol 92: e00592-18.
Online-Abstract
Schott K, Fuchs NV, Derua R, Mahboubi B, Schnellbächer E, Seifried J, Tondera C, Schmitz H, Shepard C, Brandariz-Nuñez A, Diaz-Griffero F, Reuter A, Kim B, Janssens V, König R (2018): Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.
Nat Commun 9: 2227.
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Schott K, Riess M, König R (2018): Role of Innate Genes in HIV Replication.
Curr Top Microbiol Immunol 419: 69-111.
Online-Abstract
Weydert C, van Heertum B, Dirix L, De Houwer S, De Wit F, Mast J, Husson SJ, Busschots K, König R, Gijsbers R, De Rijck J, Debyser Z (2018): Y-box-binding protein 1 supports the early and late steps of HIV replication.
PLOS ONE 13: e0200080.
Online-Abstract
Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT (2017): Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
Proc Natl Acad Sci U S A 114: 2729-2734.
Online-Abstract
Hein-Fuchs N, König R (2017): Catch Shiny Droplets in Suspension-Finding the Needle in a Haystack.
Cell Chem Biol 24: 783-784.
Online-Abstract
Riess M, Fuchs NV, Idica A, Hamdorf M, Flory E, Pedersen IM, König R (2017): Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
J Biol Chem 292: 264-277.
Online-Abstract
Schott K, König R (2017): Picking the Survivor! CRISPR Reveals HIV Dependency Factors.
Trends Microbiol 25: 243-245.
Online-Abstract
Schott K, Riess M, König R (2017): Role of Innate Genes in HIV Replication.
Curr Top Microbiol Immunol Jul 8 [Epub ahead of print].
Online-Abstract
Soonthornvacharin S, Rodriguez-Frandsen A, Zhou Y, Galvez F, Huffmaster NJ, Tripathi S, Balasubramaniam VR, Inoue A, de Castro E, Moulton H, Stein DA, Sánchez-Aparicio MT, De Jesus PD, Nguyen Q, König R, Krogan NJ, García-Sastre A, Yoh SM, Chanda SK (2017): Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.
Nat Microbiol 2: 17022.
Online-Abstract
Bähr A, Singer A, Hain A, Vasudevan AA, Schilling M, Reh J, Riess M, Panitz S, Serrano V, Schweizer M, König R, Chanda S, Häussinger D, Kochs G, Lindemann D, Münk C (2016): Interferon but not MxB inhibits foamy retroviruses.
Virology 488: 51-60.
Online-Abstract
Bonczkowski P, De Scheerder MA, Malatinkova E, Borch A, Melkova Z, König R, De Spiegelaere W, Vandekerckhove L (2016): Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models.
Sci Rep 6: 38329.
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Flory E, Riess M, Hein-Fuchs N, König R (2016): Aids: Scharade für das Immunsystem.
Dtsch Arztebl 113: A-1436 / B-1213 / C-1193.
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Guo H, König R, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefood B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM, Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK, Ting JPY (2016): NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.
Cell Host & Microbe 19: 515-528.
Online-Abstract
He L, Bardiaux B, Ahmed M, Spehr J, König R, Lünsdorf H, Rand U, Lührs T, Ritter C (2016): Structure determination of helical filaments by solid-state NMR spectroscopy.
Proc Natl Acad Sci U S A 113: E272-E281.
Online-Abstract
Kumar A, Abbas W, Colin L, Khan KA, Bouchat S, Varin A, Larbi A, Gatot JS, Kabeya K, Vanhulle C, Delacourt N, Pasquereau S, Coquard L, Borch A, König R, Clumeck N, De Wit S, Rohr O, Rouzioux C, Fulop T, Van Lint C, Herbein G (2016): Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.
Sci Rep 6: 24090.
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Marino D, Perković M, Hain A, Jaguva Vasudevan AA, Hofmann H, Hanschmann KM, Mühlebach MD, Schumann GG, König R, Cichutek K, Häussinger D, Münk C (2016): APOBEC4 Enhances the Replication of HIV-1.
PLOS ONE 11: e0155422.
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Sommer AFR, Rivière L, Qu B, Schott K, Riess M, Ni Y, Shepard C, Schnellbächer E, Finkernagel M, Himmelsbach K, Welzel K, Kettern N, Donnerhak C, Münk C, Flory E, Liese J, Kim B, Urban S, König R (2016): Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Sci Rep May 27 [Epub ahead of print].
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White KM, De Jesus P, Chen Z, Abreu P Jr, Barile E, Mak PA, Anderson P, Nguyen QT, Inoue A, Stertz S, Koenig R, Pellecchia M, Palese P, Kuhen K, García-Sastre A, Chanda SK, Shaw ML (2015): A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein.
ACS Infect Dis 1: 98-109.
Online-Abstract
König R, Stertz S (2015): Recent strategies and progress in identifying host factors involved in virus replication.
Curr Opin Microbiol 26: 79-88.
Online-Abstract
Pache L, Dutra MS, Spivak AM, Marlett JM, Murry JP, Hwang Y, Maestre AM, Manganaro L, Vamos M, Teriete P, Martins LJ, König R, Simon V, Bosque A, Fernandez-Sesma A, Cosford ND, Bushman FD, Young JA, Planelles V, Chanda SK (2015): BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency.
Cell Host Microbe 18: 345-353.
Online-Abstract
Scheuplein VA, Seifried J, Malczyk AH, Miller L, Höcker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, König R, Becker S, Waibler Z, Mühlebach MD (2015): High secretion of interferons by human plasmacytoid dendritic cells upon recognition of MERS-CoV.
J Virol 89: 3859-3869.
Online-Abstract
Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein DA, Moulton HM, DeJesus P, Che J, Mulder LC, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht RA, Gonzalez MG, Nguyen Q, Brass A, Elledge S, White M, Shapira S, Hacohen N, Karlas A, Meyer TF, Shales M, Gatorano A, Johnson JR, Jang G, Johnson T, Verschueren E, Sanders D, Krogan N, Shaw M, König R, Stertz S, Garcia-Sastre A, Chanda SK (2015): Meta- and Orthogonal Integration of Influenza 'OMICs' Data Defines a Role for UBR4 in Virus Budding.
Cell Host Microbe 18: 723-735.
Online-Abstract
White KM, De Jesus P, Chen Z, Abreu P Jr, Barile E, Mak PA, Anderson P, Nguyen QT, Inoue A, Stertz S, Koenig R, Pellecchia M, Palese P, Kuhen K, García-Sastre A, Chanda SK, Shaw ML (2015): A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein.
ACS Infect Dis 1: 98–109.
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Yoh SM, Schneider M, Seifried J, Soonthomvacharin S, Akleh RE, Olivieri KC, De Jesus PD, Ruan de Castro CE, Ruiz PA, Germanaud D, des Portes V, García-Sastre A, König R, Chanda SK (2015): PQBP1 is a Proximal Sensor of HIV-1 DNA and Initiates cGAS-dependent Innate Immune Signaling.
Cell 161: 1293-1305.
Online-Abstract
Manganaro L, Pache L, Herrmann T, Marlett J, Hwang Y, Murry J, Miorin L, Ting AT, König R, García-Sastre A, Bushman FD, Chanda SK, Young JA, Fernandez-Sesma A, Simon V (2014): Tumor Suppressor Cylindromatosis (CYLD) Controls HIV Transcription in an NF-κB-Dependent Manner.
J Virol 88: 7528-7540.
Online-Abstract
Opaluch AM, Schneider M, Chiang CY, Nguyen QT, Maestre AM, Mulder LC, Secundino I, De Jesus PD, König R, Simon V, Nizet V, Macleod G, Varmuza S, Fernandez-Sesma A, Chanda SK (2014): Positive Regulation of TRAF6-Dependent Innate Immune Responses by Protein Phosphatase PP1-γ.
PLoS One 9: e89284.
Online-Abstract
Weber C, König R, Niedrig M, Emmerich P, Schnierle BS (2014): A neutralization assay for chikungunya virus infections in a multiplex format.
J Virol Methods 201: 7-12.
Online-Abstract
Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT, Keppler OT (2012): SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Nat Med 18: 1682-1687.
Online-Abstract
Berger A, Sommer AFR, Zwarg J, Hamdorf M, Welzel K, Esly N, Panitz S, Reuter A, Ramos I, Jatiani A, Mulder LCF, Fernandez-Sesma A, Rutsch F, Simon V, König R, Flory E (2011): SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.
PLoS Pathog 7: e1002425.
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Münk C, Sommer S, König R (2011): System-biology approaches to discover anti-viral effectors of the human innate immune response.
Viruses 3: 1112-1130.
Online-Abstract
Ocwieja KE, Brady TL, Ronen K, Huegel A, Roth SL, Schaller T, James LC, Tower GJ, Young JA, Chanda SK, König R, Malani N, Berry CC, Bushman FD (2011): HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2.
PLoS Pathog 7: e1001313.
Online-Abstract
Pache L, König R, Chanda SK (2011): Identifying HIV-1 host cell factors by genome-scale RNAi screening.
Methods 53: 3-12.
Online-Abstract
König R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, Bhattacharyya S, Alamares J, Tscherne DM, Ortigoza MB, Liang Y, Gao Q, Andrew SE, Bandyopadhyay S, De Jesus P, Tu B, Pache L, Shih C, Orth A, Bonamy G, Miraglia L, Ideker T, Garcia-Sastre A, Young JAT, Palese P, Shaw ML, Chanda SK (2010): Human host factors required for influenza virus replication.
Nature 463: 813-817.
Online-Abstract
Bushmann FD, Malani N, Fernandes J, D'Orso I, Cagney G, Diamond TL, Zhou H, Hazuda DJ, Espeseth AS, König R, Bandyopadhyay S, Ideker T, Goff S, Krogan N, Frankel A, Young JA, Chanda SK (2009): Host cell factors in HIV replication: meta-analysis of genome-wide studies.
PLoS Pathog 5: e1000437.
Online-Abstract
König R, Zhou Y, Elleder D, Diamond TL, Bonamy GMC, Irelan JT, Chiang C, Tu BP, De Jesus PD, Lilley CE, Seidel S, Opaluch AM, Caldwell J, Weitzman MD, Kuhen KL, Bandyopadhyay S, Ideker T, Orth A, Miraglia LJ, Bushman FD, Young JA, Chanda SK (2008): Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.
Cell 135: 49-60.
Online-Abstract
König R, Chiang CY, Tu BP, Yan SF, De Jesus PD, Romero A, Bergauer T, Orth A, Krueger U, Zhou Y, Chanda SK (2007): A probability-based approach for the analysis of large-scale RNAi screens.
Nat Methods 4: 847-849.
Online-Abstract
Neumann J, Stitz J, König R, Seibold E, Norley S, Flory E, Cichutek K (2006): Retroviral vectors for vaccine development: Induction of HIV-1-specific humoral and cellular immune responses in rhesus macaques using a novel MLV(HIV-1) pseudotype vector.
J Biotechnol 124: 615-625.
Online-Abstract
Navarro F, Bollman B, Chen H, König R, Yu Q, Chiles K, Landau NR (2005): Complementary function of the two catalytic domains of APOBEC3G.
Virology 333: 374-386.
Online-Abstract
Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR (2004): APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.
J Biol Chem 279: 53379-53386.
Online-Abstract
Yu Q, König R, Pillai S, Chiles K, Kearney M, Palmer S, Richman D, Coffin JM, Landau NR (2004): Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome.
Nat Struct Mol Biol 11: 435-442.
Online-Abstract
Mariani R, Chen D, Schröfelbauer B, Navarro F, König R, Bollman B, Münk C, Nymark-McMahon H, Landau NR (2003): Species-specific exclusion of APOBEC3G from HIV-1 virions by VIF.
Cell 114: 21-31.
Online-Abstract
König RR, Flory E, Steidl S, Neumann J, Coulibaly C, Holznagel E, Holzammer S,, Norley S, Cichutek K (2002): Engineered CD4- and CXCR4-using simian immunodeficiency virus from African green monkeys is neutralization sensitive and replicates in nonstimulated lymphocytes.
J Virol 76: 10627-36.
Online-Abstract
Stitz J, Mühlebach MD, Blömer U, Scherr M, Selbert M, Wehner P, Steidl S, Schmitt I, König R, Schweizer M, Cichutek K (2001): A Novel Lentivirus vector derived from apathogenic simian immunodeficiency virus.
Virology 291: 191-197.
Online-Abstract
Stitz J, Steidl S, Merget-Millitzer H, König R, Müller P, Nocken F, Engelstädter M, Bobkova M, Buchholz CJ, Kurth R, Cichutek K (2000): MLV-derived retroviral vectors selective for CD4 expressing cells and are resistant to neutralisation by sera from HIV-infected patients.
Virology 267: 229-236.
Online-Abstract
Stitz J, Selbert M, Wehner P, Müller P, König R, Engelstädter M, Bobkova M, Steidl S, Schmitt I, Buchholz C, Kurth R, Cichutek K (1999): Lentiviral vectors derived from apathogenic SIVagm Deutscher AIDS-Kongreß, Essen, 02.–6.06.99.
Eur J Med Res 4: 7.
Müller P, Dittmar MT, Beer B, König R, Plesker R, Norley S, Kurth R, Cichutek K (1998): Increased serum and mRNA levels of MIP-1b and RANTES associated with elevated levels of activated CD8+CD38+ T-cells in HIV-1 infected individuals.
Intervirology.
Wagener S, Dittmar MT, Beer B, König R, Plesker R, Norley S, Kurth R, Cichutek K (1998): The U3 Promoter and the nef Gene of Simian Immunodeficiency Virus (SIV) smmPBj1.9 Do Not Confer Acute Pathogenicity upon SIVagm.
J. Virol 72: 3446-3450.
