Paul-Ehrlich-Institut

Publikationen Prof. Dr. Dr. Ute Modlich

Autorinnen und Autoren des Paul-Ehrlich-Instituts sind durch Fettdruck kenntlich gemacht. Wenn Online-Abstracts oder Volltexte zu den Publikationen verfügbar sind, so sind diese verlinkt.

Duecker R, Baer PC, Buecker A, Huenecke S, Pfeffermann LM, Modlich U, Bakhtiar S, Bader P, Zielen S, Schubert R (2020): Hematopoietic Stem Cell Transplantation Restores Naïve T-Cell Populations in Atm-Deficient Mice and in Preemptively Treated Patients With Ataxia-Telangiectasia.
Front Immunol 10: Article 2785.
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Müller S, Bexte T, Gebel V, Kalensee F, Stolzenberg E, Hartmann J, Koehl U, Schambach A, Wels WS, Modlich U, Ullrich E (2020): High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia.
Front Immunol 10: 3123.
Online-Abstract

Rommel MGE, Hoerster K, Milde C, Schenk F, Roser L, Kohlscheen S, Heinz N, Modlich U (2020): Signaling Properties of Murine MPL and MPL Mutants After Stimulation With Thrombopoietin and Romiplostim.
Exp Hermatol May 11 [Epub ahead of print].
Online-Abstract

Roth H, Schneider L, Eberle R, Lausen J, Modlich U, Blümel J, Baylis SA (2020): Zika Virus Infection Studies With CD34 + Hematopoietic and Megakaryocyte-Erythroid Progenitors, Red Blood Cells and Platelets.
Transfusion 60: 561-574.
Online-Abstract

Cullmann K, Blokland KEC, Sebe A, Schenk F, Ivics Z, Heinz N, Modlich U (2019): Sustained and regulated gene expression by Tet-inducible "All-In-One" retroviral vectors containing the HNRPA2B1-CBX3 UCOE.
Biomaterials 192: 486-499.
Online-Abstract

Kohlscheen S, Schenk F, Rommel M, Cullmann K, Modlich U (2019): Endothelial protein C receptor supports hematopoietic stem cell engraftment and expansion in Mpl-deficient mice.
Blood 133: 1465-1478.
Online-Abstract

Rommel MGE, Milde C, Eberle R, Schulze H, Modlich U (2019): Endothelial-platelet interactions in influenza-induced pneumonia: A potential therapeutic target.
Anat Histol Embryol Dec 2 [Epub ahead of print].
Online-Abstract

Brendel C, Rothe M, Santilli G, Charrier S, Stein S, Kunkel H, Abriss D, Müller-Kuller U, Gaspar B, Modlich U, Galy A, Schambach A, Thrasher AJ, Grez M (2018): Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for Ex Vivo Gene Therapy of X-Linked Chronic Granulomatous Disease.
Hum Gene Ther Clin Dev 29: 69-79.
Online-Abstract

Pfeiffer A, Thalheimer FB, Hartmann S, Frank AM, Bender RR, Danisch S, Costa C, Wels WS, Modlich U, Stripecke R, Verhoeyen E, Buchholz CJ (2018): In vivo generation of human CD19-CAR T cells results in B cell depletion and signs of cytokine release syndrome.
EMBO Mol Med 10: e9158.
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Kohlscheen S, Boenig H, Modlich U (2017): Promises and Challenges in Hematopoietic Stem Cell Gene Therapy.
Hum Gene Ther 28: 782-799.
Online-Abstract

Latorre-Rey LJ, Wintterle S, Dütting S, Kohlscheen S, Abel T, Schenk F, Wingert S, Rieger MA, Nieswandt B, Heinz N, Modlich U (2017): Targeting expression to megakaryocytes and platelets by lineage-specific lentiviral vectors.
J Thromb Haemost 15: 341-355.
Online-Abstract

Friedel T, Jung-Klawitter S, Sebe A, Schenk F, Modlich U, Ivics Z, Schumann GG, Buchholz CJ, Schneider IC (2016): CD30 receptor-targeted lentiviral vectors for human induced pluripotent stem cell-specific gene modification.
Stem Cells Dev 25: 729-739.
Online-Abstract

Dahl M, Doyle A, Olsson K, Månsson JE, Marques AR, Mirzaian M, Aerts JM, Ehinger M, Rothe M, Modlich U, Schambach A, Karlsson S (2015): Lentiviral gene therapy using cellular promoters cures type 1 Gaucher disease in mice.
Mol Ther 23: 835-844.
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Heinz N, Ehrnström B, Schambach A, Schwarzer A, Modlich U, Schiedlmeier B (2015): Comparison of Different Cytokine Conditions Reveals Resveratrol as a New Molecule for Ex Vivo Cultivation of Cord Blood-Derived Hematopoietic Stem Cells.
Stem Cells Transl Med 4: 1064-1072.
Online-Abstract

Kohlscheen S, Wintterle S, Schwarzer A, Kamp C, Brugmann MH, Breuer DC, Büsche G, Baum C, Modlich U (2015): Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance.
PLOS ONE 10: e0131866.
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Ripperger T, Manukjan G, Meyer J, Wolter S, Schambach A, Bohne J, Modlich U, Li Z, Skawran B, Schlegelberger B, Steinemann D (2015): The heteromeric transcription factor GABP activates the ITGAM/CD11b promoter and induces myeloid differentiation.
Biochim Biophys Acta 1849: 1145-1154.
Online-Abstract

Haemmerle R, Phaltane R, Rothe M, Schröder S, Schambach A, Moritz T, Modlich U (2014): Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model.
Mol Ther Nucleic Acids 3: e200.
Online-Abstract

Jaako P, Debnath S, Olsson K, Modlich U, Rothe M, Schambach A, Flygare J, Karlsson S (2014): Gene therapy cures the anemia and lethal bone marrow failure in a mouse model of RPS19-deficient Diamond-Blackfan anemia.
Haematologica 99: 1792-1798.
Online-Abstract

Phaltane R, Haemmerle R, Rothe M, Modlich U, Moritz T (2014): Efficiency and Safety of O6-Methylguanine DNA Methyltransferase (MGMTP140K)-Mediated In Vivo Selection in a Humanized Mouse Model.
Hum Gene Ther 25: 144-155.
Online-Abstract

Phaltane R, Lachmann N, Brennig S, Ackermann M, Modlich U, Moritz T (2014): Lentiviral MGMT(P140K)-mediated in vivo selection employing a ubiquitous chromatin opening element (A2UCOE) linked to a cellular promoter.
Biomaterials 35: 7204-7213.
Online-Abstract

Rothe M, Modlich U, Schambach A (2013): Biosafety challenges for use of lentiviral vectors in gene therapy.
Curr Gene Ther 13: 453-468.
Online-Abstract

Brugman MH, Suerth JD, Rothe M, Suerbaum S, Schambach A, Modlich U, Kustikova O, Baum C (2013): Evaluating a ligation-mediated PCR and pyrosequencing method for the detection of clonal contribution in polyclonal retrovirally transduced samples.
Hum Gene Ther Methods 24: 68-79.
Online-Abstract

Rittelmeyer I, Rothe M, Brugman MH, Iken M, Schambach, Manns MP, Baum C, Modlich U, Ott M (2013): Hepatic lentiviral gene transfer is associated with clonal selection, but not with tumor formation in serially transplanted rodents.
Hepatology 58: 397-408.
Online-Abstract

Rothe M, Modlich U, Schambach A (2013): Biosafety challenges for use of lentiviral vectors in gene therapy.
Curr Gene Ther 13: 453-468.
Online-Abstract

Wolf S, Rudolph C, Morgan M, Büsche G, Salguero G, Stripecke R, Schlegelberger B, Baum C, Modlich U (2013): Selection for Evi1 activation in myelomonocytic leukemia induced by hyperactive signaling through wild-type NRas.
Oncogene 32: 3028-3038.
Online-Abstract

Gaussin A, Modlich U, Bauche C, Niederlaender NJ, Schambach A, Duros C, Artus A, Baum C, Cohen-Haguenauer O, Mermod N (2012): CTF/NF1 transcription factors act as potent genetic insulators for integrating gene transfer vectors.
Gene Ther 19: 15-24.
Online-Abstract

Heckl D, Schwarzer A, Haemmerle R, Steinemann D, Rudolph C, Skawran B, Knoess S, Krause J, Li Z, Schlegelberger B, Baum C, Modlich U (2012): Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia.
Mol Ther 20: 1187-1195.
Online-Abstract

Rothe M, Rittelmeyer I, Iken M, Ruedrich U, Schambach A, Glage S, Manns MP, Baum C, Bock M, Ott M, Modlich U (2012): Epidermal growth factor improves lentivirus vector gene transfer into primary mouse hepatocytes.
Gene Ther 19: 425-434.
Online-Abstract

Baum C, Modlich U, Göhring G, Schlegelberger B (2011): Concise review: managing genotoxicity in the therapeutic modification of stem cells.
Stem Cells 29: 1479-1484.
Online-Abstract

Heckl D, Wicke DC, Brugman MH, Meyer J, Schambach A, Busche G, Ballmeier M, Baum C, Modlich U (2011): Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.
Blood 117: 3737-3747.
Online-Abstract

Wicke DC, Meyer J, Buesche G, Heckl D, Kreipe H, Li Z, Welte KH, Ballmaier M, Baum C, Modlich U (2010): Gene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia.
Mol Ther 18: 343-352.
Online-Abstract

Modlich U, Baum C (2009): Preventing and exploiting the oncogenic potential of integrating gene vectors.
J Clin Invest 119: 755-758.
Online-Abstract

Modlich U, Navarro S, Zychlinski D, Maetzig T, Knoess S, Brugman MH, Schambach A, Charrier S, Galy A, Thrasher AJ, Bueren J, Baum C (2009): Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.
Mol Ther 17: 1919-1928.
Online-Abstract

Modlich U, Schambach A, Brugman MH, Wicke DC, Knoess S, Li Z, Maetzig T, Rudolph C, Schlegelberger B, Baum C (2008): Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16.
Leukemia 22: 1519-1528.
Online-Abstract

Zychlinski D, Schambach A, Modlich U, Maetzig T, Meyer J, Grassman E, Mishra A, Baum C (2008): Physiological promoters reduce the genotoxic risk of integrating gene vectors.
Mol Ther 16: 718-725.
Online-Abstract

Modlich U, Bohne J, Schmidt M, von Kalle C, Knoss S, Schambach A, Baum C (2006): Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity.
Blood 108: 2545-2553.
Online-Abstract

Thrasher AJ, Gaspar HB, Baum C, Modlich U, Schambach A, Candotti F, Otsu M, Sorrentino B, Scobie L, Cameron E, Blyth K, Neil J, Abina SH, Cavazzana-Calvo M, Fischer A (2006): Gene therapy: X-SCID transgene leukaemogenicity.
Nature 443: E5-E6; discussion E6-E7.
Online-Abstract

Kustikova O, Fehse B, Modlich U, Yang M, Düllmann J, Kamino K, von Neuhoff N, Schlegelberger B, Li Z, Baum C (2005): Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.
Science 308: 1171-1174.
Online-Abstract

Modlich U, Kustikova OS, Schmidt M, Rudolph C, Meyer J, Li Z, Kamino K, von Neuhoff N, Schlegelberger B, Kuehlcke K, Bunting KD, Schmidt S, Deichmann A, von Kalle C, Fehse B, Baum C (2005): Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.
Blood 105: 4235-4246.
Online-Abstract

Modlich U, Pugh CW, Bicknell R (2000): Increasing endothelial cell specific expression by the use of heterologous hypoxic and cytokine-inducible enhancers.
Gene Ther 7: 896-902.
Online-Abstract