Paul-Ehrlich-Institut

Publikationen Prof. Dr. Gerald Schumann

Autorinnen und Autoren des Paul-Ehrlich-Instituts sind durch Fettdruck kenntlich gemacht. Wenn Online-Abstracts oder Volltexte zu den Publikationen verfügbar sind, so sind diese verlinkt.

Fukuda S, Varshney A, Fowler BJ, Wang S, Narendran S, Ambati K, Yasuma T, Magagnoli J, Leung H, Hirahara S, Nagasaka Y, Yasuma R, Apicella I, Pereira F, Makin RD, Magner E, Liu X, Sun J, Wang M, Baker K, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Pandey A, Pandya L, Cummings T, Banerjee D, Huang P, Yerramothu P, Tolstonog GV, Held U, Erwin JA, Paquola ACM, Herdy JR, Ogura Y, Terasaki H, Oshika T, Darwish S, Singh R, Mozaffari S, Bhattarai D, Kim KY, Hardin JW, Bennett CL, Hinton DR, Hanson TE, Röver C, Parang K, Kerur N, Liu J, Werner BC, Sutton SC, Sadda SR, Schumann GG, Gelfand BD, Gage FH, Ambati J (2021): Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration.
Proc Natl Acad Sci U S A 118: e2022751118.
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Ayyappan Jaguva Vasudevan A, Balakrishnan K, Gertzen CGW, Borveto F, Zhang Z, Sangwiman A, Held U, Küstermann C, Banerjee S, Schumann GG, Häussinger D, Bravo IG, Gohlke H, Münk C (2020): Loop 1 of APOBEC3C regulates its antiviral activity against HIV-1.
J Mol Biol Oct 15 [Epub ahead of print].
Online-Abstract

Savage AL, Ilera-Lopez A, Iacoangeli A, Bubb VJ, Smith B, Troakes C, Alahmady N, Koks S, Schumann GG, Al-Chalabi A, Quinn JP (2020): Frequency and methylation status of selected retrotransposition competent L1 loci in amyotrophic lateral sclerosis.
Mol Brain Nov 13 [Epub ahead of print].
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Savage AL, Schumann GG, Breen G, Bubb VJ, Al-Chalabi A, Quinn JP (2019): Retrotransposons in the development and progression of amyotrophic lateral sclerosis.
J Neurol Neurosurg Psychiatry 90: 284-293.
Online-Abstract

Schumann GG, Fuchs NV, Tristán-Ramos P, Sebe A, Ivics Z, Heras SR (2019): The impact of transposable element activity on therapeutically relevant human stem cells.
Mobile DNA 10.
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Singh M, Widmann TJ, Vikas Bansal, Cortes JL, Schumann GG, Wunderlich S, Martin U, Garcia-Canadas M, Garcia- Perez JL, Hurst LD, Izsvak Z (2019): The selection arena in early human blastocysts resolves the pluripotent inner cell mass.
bioRxiv Feb 4 [Epub ahead of print].
Online-Abstract

Abbot S, Agbanyo F, Ahlfors JE, Baghbaderani BA, Bartido S, Bharti K, Burke C, Carlsson B, Cavagnaro J, Creasey A, DiGiusto D, Francissen K, Gaffney A, Goldring C, Gorba T, Griffiths E, Hanatani T, Hayakawa T, Heki T, Hoogendoorn K, Kawamata S, Kimura H, Kirkeby A, Knezevic I, Lebkowski J, Lin S, Lin-Gibson S, Lubiniecki A, O'Shea O, Pera M, Petricciani J, Pigeau G, Ratcliffe A, Sato Y, Schumann GG, Shingleton W, Stacey Chair G, Sullivan S, Svendsen CN, Trouvin JH, Vandeputte J, Yuan BZ, Zoon K (2018): Report of the international conference on manufacturing and testing of pluripotent stem cells.
Biologicals 56: 67-83.
Online-Abstract

Jaguva Vasudevan AA, Kreimer U, Schulz WA, Krikoni A, Schumann GG, Häussinger D, Münk C, Göring W (2018): APOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 Expression.
Front Microbiol 9: 2088.
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Schwertz H, Rowley JW, Schumann GG, Thorack U, Campbell RA, Manne BK, Zimmerman GA, Weyrich AS, Rondina MT (2018): Endogenous LINE-1 (Long Interspersed Nuclear Element-1) Reverse Transcriptase Activity in Platelets Controls Translational Events Through RNA-DNA Hybrids.
Arterioscler Thromb Vasc Biol 38: 801-815.
Online-Abstract

Vasieva O, Cetiner S, Savage A, Schumann GG, Bubb VJ, Quinn J (2017): Potential impact of primate-specific SVA retrotransposons during the evolution of human cognitive function.
Trends Evol Biol 6: 6514.
Online-Abstract

Bock A, Schumann GG (2016): The Engineered SVA Trans-mobilization Assay.
Methods Mol Biol 1400: 203-222.
Online-Abstract

De Luca C, Guadagni F, Sinibaldi-Vallebona P, Sentinelli S, Gallucci M, Hoffmann A, Schumann GG, Spadafora C, Sciamanna I (2016): Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformation.
Oncotarget 7: 4048-4061.
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Friedel T, Jung-Klawitter S, Sebe A, Schenk F, Modlich U, Ivics Z, Schumann GG, Buchholz CJ, Schneider IC (2016): CD30 receptor-targeted lentiviral vectors for human induced pluripotent stem cell-specific gene modification.
Stem Cells Dev 25: 729-739.
Online-Abstract

Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Canadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG (2016): Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Nat Commun 7: 10286.
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Marino D, Perković M, Hain A, Jaguva Vasudevan AA, Hofmann H, Hanschmann KM, Mühlebach MD, Schumann GG, König R, Cichutek K, Häussinger D, Münk C (2016): APOBEC4 Enhances the Replication of HIV-1.
PLOS ONE 11: e0155422.
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Meyer TJ, Held U, Nevonen KA, Klawitter S, Pirzer T, Carbone L, Schumann GG (2016): The Flow of the Gibbon LAVA Element Is Facilitated by the LINE-1 Retrotransposition Machinery.
Genome Biol Evol 8: 3209-3225.
Online-Abstract

Gallus S, Hallström BM, Kumar V, Dodt WG, Janke A, Schumann GG, Nilsson MA (2015): Evolutionary histories of transposable elements in the genome of the largest living marsupial carnivore, the Tasmanian devil.
Mol Biol Evol 32: 1268-1283.
Online-Abstract

Carbone L, Harris RA, Gnerre S, Veeramah KR, Lorente-Galdos B, Huddleston J, Meyer TJ, Herrero J, Roos C, Aken B, Anaclerio F, Archidiacono N, Baker C, Barrell D, Batzer MA, Beal K, Blancher A, Bohrson CL, Brameier M, Campbell MS, Capozzi O, Casola C, Chiatante G, Cree A, Damert A, de Jong PJ, Dumas L, Fernandez-Callejo M, Flicek P, Fuchs NV, Gut M, Gut I, Hahn MW, Hernandez-Rodriguez J, Hilier LW, Hubley R, Ianc B, Izsvák Z, Jablonski NG, Johnstone LM, Karimpour-Fard A, Konkel MK, Kostka D, Lazar NH, Lee SL, Lewis LR, Liu Y, Locke DP, Mallick S, Mendez FL, Muffato M, Nazareth LV, Nevonen KA, O'Bleness M, Ochis C, Odom DT, Pollard KS, Quilez J, Reich D, Rocchi M, Schumann GG, Searle S, Sikela JM, Skollar G, Smit A, Sonmez K, ten Hallers B, Terhune E, Thomas GWC, Ullmer B, Ventura M, Walker JA, Wall JD, Walter L, Ward MC, Wheelan SJ, Whelan CW, White S, Wilhelm LJ, Woerner AE, Yandell M, Zhu B, Hammer MF, Marques-Bonet T, Eichler EE, Fulton L, Fronick C, Muzny DM, Warren WC, Worley KC, Rogers J, Wilson RK, Gibbs RA (2014): Gibbon genome and the fast karyotype evolution of small apes.
Nature 513: 195-201.
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Horn AV, Klawitter S, Held U, Berger A, Vasudevan AA, Bock A, Hofmann H, Hanschmann KM, Trösemeier JH, Flory E, Jabulowsky RA, Han J, Löwer J, Löwer R, Münk C, Schumann GG (2014): Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity.
Nucleic Acids Res 42: 396-416.
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Wang J, Xie G, Singh M, Ghanbarian AT, Raskó T, Szvetnik A, Cai H, Besser D, Prigione A, Fuchs NV, Schumann GG, Chen W, Lorincz MC, Ivics Z, Hurst LD, Izsvák Z (2014): Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Nature 516: 405-409.
Online-Abstract

Schumann GG: LINE.
In: Maloy S, Hughes K (Hrsg.), Brenner's Encyclopedia of Genetics, Vol. 4. New York: Elsevier, 2013. S. 246-249 ISBN 978-0-08-096156-9

Raiz J, Damert A, Chira S, Held U, Klawitter S, Hamdorf M, Löwer J, Strätling WH, Löwer R, Schumann GG (2012): The non-autonomous retrotransposon SVA is trans-mobilized by the human LINE-1 protein machinery.
Nucleic Acids Res 40: 1666-1683.
Online-Abstract

Zabolotneva AA, Bantysh O, Suntsova MV, Efimova N, Malakhova GV, Schumann GG, Gayfullin NM, Buzdin AA (2012): Transcriptional regulation of human-specific SVA(F1) retrotransposons by cis-regulatory MAST2 sequences.
Gene 505: 128-136.
Online-Abstract

Banaz-Yasar F, Steffen G, Hauschild J, Bongartz BM, Schumann GG, Ergün S (2010): LINE-1 retrotransposition events affect endothelial proliferation and migration.
Histochem Cell Biol 134: 581-589.
Online-Abstract

Neidhart M, Karouzakis E, Schumann GG, Gay RE, Gay S (2010): Trex-1 deficiency in rheumatoid arthritis synovial fibroblasts.
Arthritis Rheum 62: 2673-2679.
Online-Abstract

Schumann GG, Gogvadze EV, Osanai-Futahashi M, Kuroki A, Münk C, Fujiwara H, Ivics Z, Buzdin AA (2010): Unique functions of repetitive transcriptomes.
Int Rev Cell Mol Biol 285: 115-188.
Online-Abstract

Damert A, Raiz J, Horn AV, Löwer J, Wang H, Xing J, Batzer MA, Löwer R, Schumann GG (2009): 5'-transducing SVA retrotransposon groups spread efficiently throughout the human genome.
Genome Res 19: 1992-2008.
Online-Abstract

Kirilyuk A, Tolstonog GV, Damert A, Held U, Hahn S, Löwer R, Buschmann C, Horn AV, Traub P, Schumann GG (2008): Functional endogenous LINE-1 retrotransposons are expressed and mobilized in rat chloroleukemia cells.
Nucleic Acids Res 36: 648-665.
Volltext

Oricchio E, Sciamanna I, Beraldi R, Tolstonog GV, Schumann GG, Spadafora C (2007): Distinct roles for LINE-1 and HERV-K retroelements in cell proliferation, differentiation and tumor progression.
Oncogene 26: 4226-4233.
Online-Abstract

Repanas K, Zingler N, Layer LE, Schumann GG, Perrakis A, Weichenrieder O (2007): Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease.
Nucleic Acids Res 35: 4914-4926.
Online-Abstract

Schumann GG (2007): APOBEC3 proteins: major players in intracellular defence against LINE-1-mediated retrotransposition.
Biochem Soc Trans 35: 637-642.
Online-Abstract

Lucchinetti E, Feng J, da Silva R, Tolstonog GV, Schaub MC, Schumann GG, Zaugg M (2006): Inhibition of LINE-1 Expression in the Heart Decreases Ischemic Damage by Activation of Akt/PKB Signaling.
Physiol Genomics 25: 314-324.
Online-Abstract

Muckenfuss H, Hamdorf M, Held U, Perkovic M, Löwer J, Cichutek K, Flory E, Schumann GG, Münk C (2006): APOBEC3 proteins inhibit human LINE-1 retrotransposition.
J Biol Chem 281: 22161-22172.
Online-Abstract

Zingler N, Weichenrieder O, Schumann GG (2005): APE-type non-LTR retrotransposons: determinants involved in target site recognition.
Cytogenetic and Genome Research 110: 250-268.
Online-Abstract

Zingler N, Willhoeft U, Brose HP, Schoder V, Jahns T, Hanschmann KMO, Morrish TA, Löwer J, Schumann GG (2005): Analysis of 5´ junctions of human LINE-1 and Alu retrotransposons suggests an alternative model for 5´ end attachment requiring microhomology-mediated end joining.
Genome Res 15: 780-789.
Online-Abstract

Ergün S, Buschmann C, Heukeshoven J, Dammann K, Schnieders F, Lauke H, Chalajour F, Kilic N, Strätling W, Schumann GG (2004): Cell type-specific expression of LINE-1 open reading frames 1 and 2 in fetal and adult human tissues.
J Biol Chem Epub Mar 31; 279: 27753-27763.
Online-Abstract

Schumann G, Hermankova M, Cannon K, Mankowski JL, Boeke JD (2001): Therapeutic effect of a Gag-nuclease fusion protein against retroviral infection in vivo.
J Virol 75: 7030-7041.
Online-Abstract

Yu F, Zingler N, Schumann G, Strätling W (2001): Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription.
Nucleic Acids Res 29: 4493-4501.
Online-Abstract

Cannon K, Qin L, Schumann G, Boeke JD (1998): Moloney murine leukemia virus protease expressed in bacteria is enzymatically active.
Arch Virol 143: 381-388.
Online-Abstract

Feng Q, Schumann G, Boeke JD (1998): Retrotransposon R1Bm endonuclease cleaves the target sequence.
Proc Natl Acad Sci USA 95: 2083-2088.
Online-Abstract

Leng P, Klatte DH, Schumann G, Boeke JD, Steck TL (1998): Skipper, an LTR retrotransposon of Dictyostelium.
Nucleic Acids Res 26: 2008-2015.
Online-Abstract

Schumann G, Cannon K, Ma WP, Crouch R, Boeke JD (1997): Antiretroviral effect of gag-RNaseHI fusion gene.
Gene Ther 4: 593-599.
Online-Abstract

Schumann G, Qin L, Rein A, Natsoulis G, Boeke JD (1996): Therapeutic effect of Gag-nuclease fusion protein on retrovirus-infected cell cultures.
J Virol 70: 4329-4337.
Online-Abstract

Schumann G, Zündorf I, Hofmann J, Marschalek R, Dingermann T (1994): Internally located and oppositely oriented Pol II promoters direct convergent transcription of the LINE-like retroelement, the Dictyostelium Repetitive Element, from Dictyostelium discoideum.
Mol Cell Biol 14: 3074-3084.
Online-Abstract

Schumann G, Zündorf I, Schmidt A, Marschalek R, Dingermann T (1994): Characterization of transcripts from the Dictyostelium discoideum retrotransposable genetic element DRE.
Pharmazie 49: 923-925.
Online-Abstract

Hofmann J, Winckler T, Hanenkamp A, Bukenberger M, Schumann G, Marschalek R, Dingermann T (1993): The Dictyostelium discoideum 5S rDNA is organized in the same transcriptional orientation as the other rDNAs.
Biochem Biophys Res Com 191: 558-564.
Online-Abstract

Marschalek R, Hofmann J, Schumann G, Bach M, Dingermann T (1993): Different organization of the tRNA gene associated repetitive element DRE in NC4 derived strains and in other wild-type Dictyostelium discoideum strains.
Eur J Biochem 217: 627-631.
Online-Abstract

Marschalek R, Hofmann J, Schumann G, Gösseringer R, Dingermann T (1992): Structure of DRE, a retrotransposable element which integrates with position-specificity upstream of Dictyostelium discoideum tRNA genes.
Mol Cell Biol 12: 229-239.
Online-Abstract

Marschalek R, Hofmann J, Schumann G, Dingermann T (1992): Two distinct subforms of the retrotransposable DRE element in NC4 strains of Dictyostelium discoideum.
Nucleic Acids Res 20: 6247-6252.
Online-Abstract

Hofmann J, Schumann G, Borschet G, Gösseringer R, Bach M, Bertling W, Marschalek R, Dingermann T (1991): Transfer RNA genes from Dictyostelium discoideum are frequently associated with repetitive elements and contain consensus boxes in their 5'- and 3'-flanking regions.
J Mol Biol 222: 537-552.
Online-Abstract