The Paul-Ehrlich-Institut provides reference materials for in vitro diagnostic medical devices (IVD) and reference materials for immunoglobulin preparations. IVD are materials of the Paul-Ehrlich-Institut (PEI) as well as materials produced by the Paul-Ehrlich-Institut on behalf of the WHO.
Reference material means a material of sufficient homogeneity of which one or more features are specified so that they can be used to calibrate measuring instruments, to assess measuring methods or to determine their values. This material is analysed together with the testing material in a series of measurements. The traceability to international units, if any, must be given. All reference materials must be clearly identifiable and labeled. When handling reference materials, especially in refrigerated or frozen storage, care should be taken to ensure that labels are not damaged.
Updated: 12.05.2022
Product Code
#11785/16
Description
Chikungunya Virus RNA for NAT-based Assays, 1st WHO International Standard, 2017
Instructions for Use (IFU)
IFU-Chikungunya Virus RNA Standard
Report on the international ring study
ECBS Report Chikungunya Virus RNA Standard
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#1502/19
Description
Anti-Chikungunya Virus Immunoglobulin G, 1st WHO International Standard, 2022
Instructions for Use (IFU)
IFU Anti-Chikungunya Virus Immunoglobulin G
Report on the international ring study
ECBS Report on Collaborative Study to Evaluate a Candidate World Health Organization International Standard for Antibodies to Chikungunya Virus
Source Material and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#136616/17
Description
Anti-Cytomegalovirus Ig G (anti-CMV IgG), WHO 1st International Standard
Instructions for Use (IFU)
IFU anti-CMV IgG
International Collaborative Study Report
ECBS Report anti-CMV IgG
Source Materials ans Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#5086/08
Description
Hepatitis B Virus Genotype Panel for NAT-based Assays, 1st WHO International Reference Panel, 2009
Instructions for Use (IFU)
IFU HBV genotype panel for NAT assays
Report on the international ring study
ECBS Report HBV genotype panel for NAT assays
Source Materials and Sequences
5086/08 Sequences of the samples 1-15 and phylogenetic trees
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#129097/12
Description
Hepatitis B virus "e" antigen (HBeAg), 1st International Standard 2013
Instructions for Use (IFU)
IFU HBeAg
Report on the International Ring Study
ECBS Report HBeAg
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#6100/09
Description
Hepatitis B Virus Genotype Panel for HBsAg-based Assays, 1st WHO International Reference Panel, 2011
Instructions for Use (IFU)
IFU HBV genotype panel
Report on the international ring study
ECBS Report HBV genotype panel for HBsAgAssays
Source Materials and Sequences
6100/09 Source materials
6100/09 Sequences of the Samples 4
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#129095/12
Description
Anti-hepatitis B virus "e" antigen (anti-HBe), 1st International Standard 2013
Instructions for Use (IFU)
IFU anti-HBe
Report on the International Ring Study
ECBS Report anti-HBe
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#129096/12
Description
Hepatitis C Virus Core Antigen (HCV core Ag), for HCV core antigen assays 1st WHO International Standard, 2014
Instructions for Use (IFU)
IFU HCV core Ag
International Collaborative Study Report
ECBS Report HCV core Ag
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#7657/12
Description
Hepatitis D Virus RNA for NAT-based Assays, 1st WHO International Standard, 2013
Instructions for Use (IFU)
IFU HDV RNA
Report on the international ring study
ECBS Report HDV RNA
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#6329/10
Description
Hepatitis E Virus RNA for NAT-based assays, 1st International Standard 2011
Instructions for Use (IFU)
IFU HEV RNA
Report on the international ring study
ECBS Report HEV RNA
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Price per unit
100 €
Product Code
#8578/13
Description
Hepatitis E virus RNA genotype panel for NAT-based assays, 1st International Standard
Instructions for Use (IFU)
IFU HEV RNA reference panel
Report on the international ring study
ECBS Report HEV RNA reference panel
Source Material and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#1500/19
Description
Anti-Ross River Virus (anti-RRV) neutralising antibodies, 1st WHO International Standard, 2023
Instructions for Use (IFU)
Anti-Ross River Virus (Anti-RRV) Standard
Report on the international ring study
ECBS Report Anti-Ross River Virus Standard
Source Material and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#11468/16
Description
Zika virus RNA for NAT-based assays 1st International Standard, 2016
Instructions for Use (IFU)
IFU Zika Virus RNA
Report on the international ring study
ECBS Report Zika Virus RNA
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#8293/13
Description
Mycoplasma DNA for NAT-based assays designed for generic mycoplasma detection, 1st International Standard
Instructions for Use (IFU)
IFU Mykoplasma DNA
Report on the international ring study
ECBS Report Mycoplasma DNA
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#8483/13
Description
Instructions for Use (IFU)
IFU Bacteria Reference Panel
Report on the international ring study
ECBS Report Bacteria Reference Panel
Source Materials and Sequences
not available
Special Requirements
Infectious/deep frozen (dry-ice shipment)
Product Code
#11162/16, #11163/16, #11164/16, #11165/16, #11166/16, #11167/16, #11168/16, #11169/16, #11170/16, #11171/16
Description
Instructions for Use (IFU)
IFU Bacteria Reference Panel - Enlargement
Report on the international ring study
ECBS Report Bacteria Reference Panel - Enlargement
Source Materials and Sequences
not available
Special Requirements
Infectious/deep frozen (dry-ice shipment)
Product Code
#11167/16, #11180/20, #11181/20, #11182/20, #11183/20
Description
Instructions for Use (IFU)
IFU RBC Reference Bacteria
Report on the international ring study
ECBS Report on Red Blood Cell Transfusion-Relevant Bacterial Reference Strains
Source Materials ans Sequences
not available
Special Requirements
Infectious/deep frozen (dry-ice shipment)
Updated: 04.01.2024
Product Code
#3620/05
Description
PEI Reference Preparation HBV DNA
Instructions for Use (IFU)
PEI Reference Preparation HBV DNA (#3620/05)
Report on the International Ring Study
not available
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#3443/04
Description
PEI Reference Preparation HCV RNA
Instructions for Use (IFU)
PEI Reference Preparation HCV RNA (#3443/04)
Report on the International Ring Study
not available
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#12585/18
Description
PEI Control Reagent HEV RNA
Instructions for Use (IFU)
PEI Controll Reagent HEV RNA (#12585/18) (German)
Report on the International Ring Study
not available
Source Materials and Sequences
not available
Special Requirements
Infectious/deep frozen (dry-ice shipment)
Product Code
#3441/04
Description
PEI Reference Preparation HIV-1 RNA
Instructions for Use (IFU)
PEI Reference Preparation HIV-1 RNA (#3441/04)
Report on the International Ring Study
not available
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#13299/19
Description
PEI Reference Preparation WNV RNA (Lineage 1)
Instructions for Use (IFU)
PEI Reference Preparation WNV RNA, Lineage 1 (#13299/19)
Report on the International Ring Study
not available
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Product Code
#13300/19
Description
PEI Reference Preparation WNV RNA (Lineage 2)
Instructions for Use (IFU)
PEI Reference Preparation WNV RNA, Lineage 2 (#13300/19)
Report on the International Ring Study
not available
Source Materials and Sequences
not available
Special Requirements
Infectious/lyophilized (no dry-ice shipment)
Updated: 27.10.2023
The purchase of our reference material is limited to 5 standards (panels) per year for each preparation (exception: WHO HEV reference preparations are limited to 2 per year).
Reference Material Webshop (Paul-Ehrlich-Institut and WHO)
Email: refmat@pei.de
Updated: 27.10.2023
The IMI COMBINE Preclinical Bacterial Strain Repository (PBSR) contains bacterial pathogens which are currently evaluated in a COMBINE consensus infection protocol as putative reference strains for preclinical efficacy studies to support harmonisation and comparability of efficacy studies for antimicrobial drug development. The COMBINE PBSR is a dynamically growing resource with strains and characterisation data being added as they become available.
The products of this category are not available via our reference material webshop but have been deposited to the German Collection of Microorganisms and Cell Cultures (DSMZ) for distribution. Links to the respective DSMZ catalogue entry are provided in the strain descriptions.
Product Code
DSM 30104
Historical ID
ATCC13883
Description
Klebsiella pneumoniae
Data sheet
COMBINE PBSR DSM 30104
Virulence
≥ 1 log CFU increased bacterial burden in ≤ 26 h in a neutropenic CD1 mouse lung infection model
Reference treatment
pending
Ring study
pending
Product Code
DSM 116098
Historical ID
KP.C1.104
Description
Klebsiella pneumoniae
Data sheet
COMBINE PBSR DSM 116098
Virulence
≥ 1 log CFU increased bacterial burden in ≤ 26 h in a neutropenic CD1 mouse lung infection model
Reference treatment
pending
Ring study
pending
Product Code
DSM 116099
Historical ID
KP.C1.112
Description
Klebsiella pneumoniae
Data sheet
COMBINE PBSR DSM 116099
Virulence
≥ 1 log CFU increased bacterial burden in ≤ 26 h in a neutropenic CD1 mouse lung infection model
Reference treatment
pending
Ring study
pending
Product Code
DSM 116109
Historical ID
KP.C1.181
Description
Klebsiella pneumoniae
Data sheet
COMBINE PBSR DSM 116109
Virulence
≥ 1 log CFU increased bacterial burden in ≤ 26 h in a neutropenic CD1 mouse lung infection model
Reference treatment
pending
Ring study
pending
Product Code
DSM 50071
Historical ID
n.a.
Description
Pseudomonas aeruginosa
Data sheet
COMBINE PBSR DSM 50071
Virulence
≥ 1 log CFU increased bacterial burden in ≤ 26 h in a neutropenic CD1 mouse lung infection model
Reference treatment
pending
Ring study
pending
Product Code
DSM 116114
Historical ID
PA88276
Description
Pseudomonas aeruginosa
Data sheet
COMBINE PBSR DSM 116114
Virulence
≥ 1 log CFU increased bacterial burden in ≤ 26 h in a neutropenic CD1 mouse lung infection model
Reference treatment
pending
Ring study
pending
Product Code
DSM 116116
Historical ID
PA88356
Description
Pseudomonas aeruginosa
Data sheet
COMBINE PBSR DSM 116116
Virulence
≥ 1 log CFU increased bacterial burden in ≤ 26 h in a neutropenic CD1 mouse lung infection model
Reference treatment
pending
Ring study
pending
Dr Bernhard Kerscher
Email: imi-combine@pei.de
Updated: 05.06.2025
