Paul-Ehrlich-Institut

Re­search and Third-Par­ty Fund­ing

Funded research projects and third-party funded projects at the Paul-Ehrlich-Institut (PEI)

BMG | Federal Ministry of Health

Project ManagerProject DescriptionDuration
Dr Gabriele UngerActivity as WHO Collaborating Center for Blood Products an IVD Devices01.01.2010 - 31.12.2025
Dr Christoph ConradGHPP | Global Health Protection Programme RegTrain-VaccTrain: Regulatory training and advice in the field of vaccines and biomedical therapeutics01.01.2019 - 31.12.2022
Dr Anneliese HilgerGHPP | Global Health Protection Programme BloodTrain: Availability, safety and quality of blood and blood products01.01.2019 - 31.12.2022
Prof Dr Veronika von MesslingSafety of vaccines against zika and other flaviviruses01.12.2016 - 31.12.2023
Prof Dr Gerald G. SchumannSafety of human pluripotent stem cells in the use for somatic cell therapy01.01.2019 - 31.12.2021
Prof Dr van Ger ZandbergenEstablishment of an assessment system for innovative adjuvants01.07.2015 - 31.03.2020
Prof Dr Christian BuchholzStudies on acute side effects of CAR-T cells in mouse models01.11.2018 - 31.10.2022
Dr Michael MühlebachSafety and standardisation of measles vaccine strain derived vaccines against highly pathogenic bacteria01.11.2018 - 28.02.2022
Prof Dr Rainer Seitz
Dr Christoph Conrad
GHPP | Global Health Protection Programme BloodTrain: Safety and quality of blood and blood products - support for the development of a regulatory structure and its adaptation to crisis situations in the partner countries01.04.2016 - 31.12.2022
Dr Renate KönigRegulatory use of BigData strategies based on OMICS data for efficient development, approval and safe use of biological medicinal products01.12.2021 - 31.12.2026
Dr Renate KönigRegulatory use of AI-supported methods for the efficient evaluation and regulation of biomedical drugs01.03.2022 - 31.12.2024
Dr Renate KönigIntegrated Network for Monitoring and Identification of Infectious Disease Risks01.03.2022 - 31.12.2024
Dr Elena Wolff-HolzRegulatory research on quality data (physicochemical and functional assays) versus clinical data (PK and phase 3 efficacy study) in the approval of biosimilars01.10.2022 - 30.06.2025

BMBF | Federal Ministry of Education and Research

Project ManagerProject DescriptionDuration
Prof Dr Stefan ViethsDIFAMEM | Dietary intervention in food allergy: microbiome, epigenetic and metabolomic interactions 01.03.2019 - 30.06.2023
Dr. Verena Klümpers,
Dr. Micha Nübling,
Dr. Alexander Pinz
BISKIT | Blood Information System for Crisis Intervention and Management - Subproject: Processes and Structures01.04.2020 - 31.03.2023
Dr Nadine Kirsch-Stefan,
Dr Christoph Conrad
OSRA-PEI01.01.2021 - 28.02.2026
Dr Michael MühlebachJoint project | Emergency Vaccines PEI-TP: Recombinant measles virus vaccine platform01.01.2021 - 28.02.2026
Dr Bevan SawatskyDZIF | German Center for Infection Research: Animal facility for testing vaccines and antivirals against newly emerging infections under BSL 3/4 conditions01.02.2021 - 28.02.2026
Prof Dr Christian BuchholzCOMMUTE | (16GW0339) Drug delivery: combinatorial and multidisciplinary targeting of effective gene therapy vectors - rational design of receptor targeting AAV particles with DARPins01.03.2021 - 29.02.2024
Dr Martina Schüßler-LenzRegulatorische Analyse und Optimierung der Translation von Entwicklungskandidaten im DKTK01.06.2021 - 31.05.2024
Prof Dr Oleg Krut,
Dr Ingo Spreitzer
Establishment of the monocyte activation test in the risk assessment of masked endotoxins in medicinal products (PyroSafe)01.04.2022 - 31.03.2025
Dr Richard BrownVIRASCREEN - Production of cDNA libraries for the identification of new host factors involved in the replication of zoonotic viruses01.07.2022 - 31.12.2023
Dr Olga TicháAlternative methods | Functional assay for B cell activation by toxoid vaccines (BCELL-ACT-2)01.08.2022 - 31.07.2024

DFG | German Research Foundation

Project ManagerProject DescriptionDuration
Dr Stephan ScheurerImmune modulating mechanisms of flagellin A (FlaA)-fusion proteins at the interface between cell metabolism, TLR signaling, and inflammasome activation: WP2: TLR5/NLRC4-mediated activation01.03.2019 - 31.12.2022
Dr Stefan SchülkeImmune modulating mechanisms of flagellin A (FlaA)-fusion proteins at the interface between cell metabolism, TLR signaling, and inflammasome activation: WP1: Immune metabolism01.05.2019 - 31.12.2022
Prof Dr Ralf R. Tönjes
Dr Antonia W. Godehardt
Biology of xenogenic cell, tissue and organ transplantation from basic research to clinical application01.07.2012 - 30.06.2024
Prof Dr Zoltán IvicsModeling of cerebellar pathology in ataxia-telangiectasia: study of ATM-deficient mice versus human iPS cells01.01.2020 - 31.12.2022
Prof Dr Ute ModlichHematopoietic stem cell-directed gene therapy for the treatment of ataxia telangiectasia (A-T)01.04.2020 - 31.03.2023
Prof Dr Ute ModlichEpcr expression and Epcr / Par1 signaling pathways in Mpl deficient and normal hematopoiesis during transplantation01.06.2020 - 31.05.2023
Prof Dr Ger van ZandbergenCell death dependence of the emergence of leishmania from infected host macrophages01.12.2020 - 30.11.2023
Dr Bevan Sawatsky
Dr Christian Pfaller
Mechanistic studies of morbillivirus-associated immunosuppression and antiviral immune responses against these viruses01.01.2021 - 31.12.2021
Dr Renate KönigInvestigation of the cellular mechanisms of the PQBP1-mediated innate immune response to HIV-101.10.2020 - 30.09.2023
Dr Michael MühlebachBroad-spectrum HPV vaccine based on recombinant measles01.10.2021 - 30.09.2024
Dr Renate KönigTargeting converging mechanisms of inefficient immunity in tumor diseases and chronic infections01.01.2022 - 31.12.2025
Prof Dr Eberhard HildtHBV over time: characteristics of viral pathogenesis in different disease phases01.03.2022 - 28.02.2025
Dr Jessica RoosInvestigation of nitroalkylation as a novel endogenous regulatory mechanism and therapeutic target on the ubiquitin-proteasome system01.01.2023 - 31.12.2025
Prof Dr Thorsten Jürgen MaierInvestigation on the effects of carbapenems on leukocyte-endothelial interaction in models of pulmonary inflammation and viral infection

EU | European Union

Project ManagerProject DescriptionDuration
Dr Elisabeth Balks
Dr Andreas Reuter
Prof Dr Isabelle Bekeredjian-Ding
VAC2VAC | Vaccine batch to vaccine batch comparison by consistency testing01.03.2016 - 28.02.2022
Prof Dr von Veronika MesslingCrimean-Congo haemorrhagic fever vaccine (CCHFVaccine)01.01.2017 - 31.12.2022
Prof Dr Zoltan IvicsCARAMBA | SLAMF7-CAR T cells prepared by sleeping beauty gene-transfer for immunotherapy of multiple myeloma - a rare hematologic disease01.01.2018 - 30.04.2022
Priv-Doz Dr Dorothea Stahl
Birgit Haschberger
GAPP | Facilitating the authorisation of preparation process for blood and tissues and cells01.05.2018 - 31.01.2022
Bettina ZiegeleSTARS | Strengthening training of academia in regulatory sciences and supporting regulatory scientific advice01.01.2019 - 30.06.2022
Prof Dr Christian BuchholzSTACCATO | Enhancing the manufacture of advanced biological medicine through high-resolution analysis of single cells01.01.2019 - 31.12.2022
PD Dr. Benjamin HofnerEU-PEARL | Integrated research platforms enabling patient-centric drug development01.11.2019 - 30.04.2023
Prof Dr Zoe WaiblerimSAVAR | Emerging translational safety technologies and tools for interrogating human immuno-biology01.11.2019 - 31.10.2025
Prof Dr Isabelle Bekeredjian-DingCOMBINE | Collaboration for Prevention and Treatment of MDR Bacterial Infections01.11.2019 - 31.10.2025
Prof Dr Isabelle Bekeredjian-DingTIPAT | Training towards Personalized Antibiotic Treatment01.03.2020 - 29.02.2024
Prof Dr Zoltan Ivics
Prof Dr Christian Buchholz
T2EVOLVE | Accelerating Development and Improving Access to CAR and TCR-engineered T cell therapy01.01.2021 - 31.12.2025
Dr J. HartmannT-OP | Training Network for Optimizing Adoptive T cell Therapy of Cancer 01.03.2021 - 28.02.2025
Prof Dr Isabelle Bekeredjian-DingINNO4VAC | Innovations to accelerate vaccine development and manufacture01.09.2021 - 28.02.2027
Dr Thomas HolzhauserALLPreT | Allergenicity Prediction Toolbox for novel foods 01.09.2022 - 28.02.2025

LOEWE-Centres | State of Hesse

Project ManagerProject DescriptionDuration
Dr. Frederic ThalheimerIn situ CAR T cell generation in primary patient material using receptor-targeted AAV vectors01.01.2022 - 31.12.2022
Prof Dr Eberhard HildtLOEWE Center DRUID | PaaP: Protease Activatable Antiviral Prodrugs01.10.2021 - 30.09.2023
Prof Dr Eberhard Hildt, Dr. Daniela Bender Novel Drug Targets against Poverty-Related and Neglected Tropical Infectious Diseases: Targets for antiviral strategies against the Zika virus01.01.2022 - 31.12.2024
Prof Dr Eberhard HildtNovel Drug Targets against Poverty-Related and Neglected Tropical Infectious Diseases: Identification of cellular targets for antiviral strategies - Inhibition of virus release through modulation of cholesterol levels01.01.2022 - 31.12.2024
Prof Dr Ger van ZandbergenNovel Drug Targets against Poverty-Related and Neglected Tropical Infectious Diseases: Characterisation of apoptotic parasites to identify new targets for the treatment of leishmaniasis01.01.2022 - 31.12.2024
Dr Jacomina Krijnse-LockerNovel Drug Targets against Poverty-Related and Neglected Tropical Infectious Diseases: W2 Professorship for Pathogen Imaging and Immunology01.01.2022 - 31.12.2024
Prof Dr Christian BuchholzVektor-Core01.01.2023 - 31.12.2025

Various

BLE | Federal Office for Agriculture and Food

Project ManagerProject DescriptionDuration
Prof Dr Stefan Vieths
Dr Melanie Albrecht
ZeBaP | Development and validation of a cell-based test system for the detection of traces of allergens and for the determination of the allergenic potential of processed foods01.04.2020 - 31.03.2023
Dr Thomas HolzhauserDevelopment of an allergen-containing test biscuit for a special diet for babies - the food kiss (Solids-by-Kiss)01.01.2021 - 31.12.2023

DAAD | German Academic Exchange Service

Project ManagerProject DescriptionDuration
Dr Richard Brown  Doctoral scholarship to Ms Tabitha Kavuli Itotia for the project: Comparison of host immunological responses to SARS-CoV-2 infection and vaccination in Africans and Europeans01.10.2021 - 30.09.2023

DGUV | German Statutory Accident Insurance

Project ManagerProject DescriptionDuration
Prof Dr Vera Mahler  Quality assurance of the diagnosis of occupational type I allergies01.11.2020 - 31.10.2023

EDQM | European Directorate for the Quality of Medicine

Project ManagerProject DescriptionDuration
Prof Dr Stefan ViethsRecombinant major allergens (BRPs and assay methods)undetermined

German Cancer Aid

Project ManagerProject DescriptionDuration
Prof Dr Christian BuchholzIn vivo generation of CAR T cells in an immunocompetent large animal model01.06.2021 - 31.05.2024

German José Carreras Foundation

Project ManagerProject DescriptionDuration
Dr Jessica HartmannThe importance of the bone marrow microvasculature for the therapeutic effectiveness of CAR NK cells and CAR T cells in acute leukemia15.11.2021 - 14.11.2024

ISBT | International Society of Blood Transfusion

Project ManagerProject DescriptionDuration
Dr Marcel PraxEstablishment of platelet bacterial reference strains in BioBall formatfrom 2019

NIH | National Institut of Health

Project ManagerProject DescriptionDuration
Prof Dr Christian BuchholzDisabling the replication-competent HIV provirus in the reservoir by combined CRISPR-Cas action05.04.2019 - 05.04.2023

Rudolf Marx Foundation

Project ManagerProject DescriptionDuration
Prof Dr Ger van Zandbergen
Prof Dr Jacomine Krijnse Locker
Studies on the influence of a2-macroglobulin on the infectivity of SARS-CoV-2 in cell cultureindefinite

SET | Foundation for the Promotion of Research into Alternative and Complementary Methods to Limit Animal Experiments

Project ManagerProject DescriptionDuration
PD Dr Christel KampSpectroscopic determination of vaccine components01.01.2023 - 31.12.2024

Updated: 02.12.2022