Paul-Ehrlich-Institut

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Al­ler­gol­o­gy Re­search Group

Dahlienpolle (K.Boller/Paul-Ehrlich-Institut)

Research Focus

An indispensable basis for the multifaceted tasks of the Allergology Division is its own experimental research. The section conducts research in coordination with the Head of Division and provides experimental-scientific support for the regulatory tasks of the Allergology Division at national and European level.

This includes conducting both basic research and research related to products and regulations on allergen products derived from natural extracts as well as biotechnologically or synthetically produced variants and peptides of allergens and on the standardisation of extract-based allergen preparations. In addition, the interaction of allergens/allergen-containing biomedical products and the organism is investigated. One focus here is on the immune metabolic characterisation and mechanistic investigation of novel adjuvants for allergen-specific immunotherapy and the identification of individual target structures and co-factors of the allergic immune response for the targeted modulation of the allergic immune response.

The scientific knowledge gained serves as a basis for better diagnoses and therapy of allergic diseases and additionally creates prerequisites for improved product testing and drug assessment.

Overview of the topics worked on in the research group. Overview of the topics worked on in the research group. Source: Paul-Ehrlich-Institut

Research Group Head

PD Dr Stefan Schüllke
Publications
Email: Stefan.Schuelke@pei.de

Professor Dr Vera Mahler
Publications
Email: Vera.Mahler@pei.de

Research Projects

Research focus 1 – Regulation-related research and innovative product testing to ensure high quality, safe, and effective allergen products for allergy diagnostics and therapy:

  • Investigations on the occurrence and significance of Api m 10 and other allergen components in therapy allergen products
  • Quality control of the diagnostics for occupational type I allergies
  • Establishment of replacement batches for the recombinant major allergens Bet v 1 and Phl p 5a Ph. Eur. reference standards
  • Review of the allergen content of birch pollen over time (10 years).

Research focus 2 – Clarification of basic questions on the interaction of allergens/allergen-containing biomedical products and the organism:

  • Epitope recognition of model allergens and clinical severity of allergy manifestation.

Research focus 3 – Identification of individual target structures and co-factors for the targeted modulation of the allergic immune response:

  • Exploration of the immune modulatory properties of the flagellin:allergen fusion protein rFlaA:Betv1
  • Investigation of the immune modulating potential of novel adjuvants in the context of allergen-specific Th2 responses.

Updated: 10.01.2024