Paul-Ehrlich-Institut

Molec­u­lar Al­ler­gol­o­gy Re­search Group

Research at the Vice President

Research Group Molecular Allergology Left to right: Yen-Ju Lin, Stephan Scheurer, Annette Jamin, Sonja Wolfheimer, Maren Krause, Frank Eliezer Blanco Perez, Maike Schott, Melanie Albrecht, Andrea Wangorsch, Stefan Schülke, Alexandra Goretzki, Clara Meier Source: PEI

Research Team

Professor Dr Stefan Vieths (Vice President of the Paul-Ehrlich-Institut)
PD Dr Stephan Scheurer (Head of Section)
Dr Stefan Schülke (Deputy Head of Section, Project Leader)
Dr Melanie Albrecht (Scientist, Project Leader)
Dr Frank Eliezer Blanco Perez (Scientist)
Alexandra Goretzki (PhD Student)
Annette Jamin (Technical Assistant)
Maren Krause (Technical Assistant)
Yen-Ju Lin (PhD Student)
Dr Laura Martin-Pedraza (Scientist, Scholarship Holder)
Maike Schott (PhD Student)
Hanna Steigerwald (PhD Student)
Dr Andrea Wangorsch (Scientist)
Sonja Wolfheimer (Technician)
Elisa Zubeldia Varela (Scientist, Scholarship Holder)

Research Summary

The prevalence of IgE-mediated (type I) allergies is increasing worldwide. Our modern life style is accompanied by a high standard of hygiene and fewer microbial infections. These factors in association with the geographical spreading of allergens as a result of climate change are potentially contributing to the increasing incidence of allergic diseases. Both, pathogenesis and mechanism of allergen-specific immunotherapy (AIT) are still not fully elucidated. Current AIT frequently is inconvenient for patients, and can sometimes be accompanied by unwanted adverse side effects. Although allergen-specific immunotherapy is well established for certain inhalant allergies, it can be less effective depending on the type of allergy. Therefore, novel immunotherapy strategies to enhance safety and efficacy have become an important area of investigation.

Our research focuses on the underlying mechanisms for the pathogenesis of allergic diseases, the molecular characterization of food and inhalant allergens, and their applications in in vitro diagnosis as well as for the development of novel intervention strategies for the prevention and treatment of IgE-mediated allergies. In line with this, experimental mouse allergy models, and mouse and human in vitro cell culture assays have been utilized to elucidate the pathology of (food) allergies and the immune modulation by recombinant vaccine candidates.

The pathogenesis of IgE-mediated allergies is characterized by a predominantly TH2 immune response and production of allergen-specific IgE antibodies. The pathogenesis of IgE-mediated allergies is characterized by a predominantly TH2 immune response and production of allergen-specific IgE antibodies. Source: PEI

Head of Research Group

Dr Stephan Scheurer
Publications
Phone: +49 6103 77 5310
Email: Stephan.Scheurer@pei.de

Updated: 21.01.2021