Navigation and service

Molecular Allergology

Publications

Who we are

Research Team - Molecular AllergologyLeft to right: Dr. Héla Safi, Annette Jamin, Frank Eliezer Blanco Perez, Garibald Papp, Dr. Jonathan Emiliano Laiño, Maren Krause, Sonja Wolfheimer, Dr. Masako Toda, Dr. Stephan Scheurer, Dr. Andrea Wangorsch, Dr. Stefan Schülke, Prof. Dr. Stefan Vieths. Source: PEI

Prof. Dr. Stefan Vieths (Vice President)
Dr. Stephan Scheurer (Section Head)
Dr. Jonathan Emiliano Laiño (Research Scientist)
Dr. Stefan Schülke (Research Scientist, Deputy Head)
Dr. Andrea Wangorsch (Research Scientist)
Annette Jamin (Technical Assistant)
Maren Krause (Technical Assistant)
Sonja Wolfheimer (Technical Assistant)
Frank Eliezer Blanco Perez (PhD Student)
Dr. Héla Safi (Visiting Scientist)
Garibald Papp (Visiting MD Student)
Alexandra Goretzki (Student/Trainee)

Research Summary

The prevalence of IgE-mediated (type I) allergies is increasing worldwide. Our modern life style is accompanied by a high standard of hygiene and fewer microbial infections. These factors in association with the geographical spreading of allergens as a result of climate change are potentially contributing to the increasing incidence of allergic diseases. Both, pathogenesis and mechanism of allergen-specific immunotherapy (AIT) are still not fully elucidated. Current AIT frequently is inconvenient for patients, and can sometimes be accompanied by unwanted adverse side effects. Although allergen-specific immunotherapy is well established for certain inhalant allergies, it can be less effective depending on the type of allergy. Therefore, novel immunotherapy strategies to enhance safety and efficacy have become an important area of investigation.

Our research focuses on the underlying mechanisms for the pathogenesis of allergic diseases, the molecular characterization of food and inhalant allergens, and their applications in in vitro diagnosis as well as for the development of novel intervention strategies for the prevention and treatment of IgE-mediated allergies. In line with this, experimental mouse allergy models, and mouse and human in vitro cell culture assays have been utilized to elucidate the pathology of (food) allergies and the immune modulation by recombinant vaccine candidates.

The pathogenesis of IgE-mediated allergies is characterized by a predominantly TH2 immune response and production of allergen-specific IgE antibodies. The pathogenesis of IgE-mediated allergies is characterized by a predominantly TH2 immune response and production of allergen-specific IgE antibodies.The pathogenesis of IgE-mediated allergies is characterized by a predominantly TH2 immune response and production of allergen-specific IgE antibodies. Source: PEI

Summary of ongoing research projects

  1. Molecular allergy diagnosis & characterization of allergens
  2. Pathomechanism of IgE-mediated allergies using experimental allergy models
  3. Preclinical development of recombinant allergen vaccines

How do you rate this article

This Page