Head: Dr. Stephan Scheurer
Who we are
Prof. Dr. Stefan Vieths (Vice President)
Dr. Stephan Scheurer (Section Head)
Dr. Stefan Schülke (Research Scientist, Deputy Head)
Dr. Andrea Wangorsch (Research Scientist)
Annette Jamin (Technical Assistant)
Maren Krause (Technical Assistant)
Sonja Wolfheimer (Technical Assistant)
Frank Eliezer Blanco Perez (PhD Student)
The prevalence of IgE-mediated (type I) allergies is increasing worldwide. Our modern life style is accompanied by a high standard of hygiene and fewer microbial infections. These factors in association with the geographical spreading of allergens as a result of climate change are potentially contributing to the increasing incidence of allergic diseases. Both, pathogenesis and mechanism of allergen-specific immunotherapy (AIT) are still not fully elucidated. Current AIT frequently is inconvenient for patients, and can sometimes be accompanied by unwanted adverse side effects. Although allergen-specific immunotherapy is well established for certain inhalant allergies, it can be less effective depending on the type of allergy. Therefore, novel immunotherapy strategies to enhance safety and efficacy have become an important area of investigation.
Our research focuses on the underlying mechanisms for the pathogenesis of allergic diseases, the molecular characterization of food and inhalant allergens, and their applications in in vitro diagnosis as well as for the development of novel intervention strategies for the prevention and treatment of IgE-mediated allergies. In line with this, experimental mouse allergy models, and mouse and human in vitro cell culture assays have been utilized to elucidate the pathology of (food) allergies and the immune modulation by recombinant vaccine candidates.
Summary of ongoing research projects
- Molecular allergy diagnosis & characterization of allergens
- Pathomechanism of IgE-mediated allergies using experimental allergy models
- Preclinical development of recombinant allergen vaccines