Paul-Ehrlich-Institut

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Publications in 2016

Please note: Authors from the Paul-Ehrlich-Institut are highlighted in bold. For online abstracts or full text publications, please follow the links.

Abrusán G, Yant SR, Szilágyi A, Marsh JA, Mátés L, Izsvák Z, Barabás O, Ivics Z (2016): Structural Determinants of Sleeping Beauty Transposase Activity.
Mol Ther 24: 1369-1377.
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Adam A, Seidahmed OM, Weber C, Schnierle B, Schmidt-Chanasit J, Reiche S, Jassoy C (2016): Low Seroprevalence Indicates Vulnerability of Eastern and Central Sudan to Infection with Chikungunya Virus.
Vector Borne Zoonotic Dis 16: 290-291.
Online-Abstract

Adlhoch C, Avellon A, Baylis SA, Ciccaglione AR, Couturier E, de Sousa R, Epštein J, Ethelberg S, Faber M, Fehér Á, Ijaz S, Lange H, Manďáková Z, Mellou K, Mozalevskis A, Rimhanen-Finne R, Rizzi V, Said B, Sundqvist L, Thornton L, Tosti ME, van Pelt W, Aspinall E, Domanovic D, Severi E, Takkinen J, Dalton HR (2016): Hepatitis E virus: Assessment of the epidemiological situation in humans in Europe, 2014/15.
J Clin Virol 82: 9-16.
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Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA (2016): Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe.
N Engl J Med 374: 1647-1660.
Online-Abstract

Alessio AP, Fili AE, Garrels W, Forcato DO, Olmos Nicotra MF, Liaudat AC, Bevacqua RJ, Savy V, Hiriart MI, Talluri TR, Owens JB, Ivics Z, Salamone DF, Moisyadi S, Kues WA, Bosch P (2016): Establishment of cell-based transposon-mediated transgenesis in cattle.
Theriogenology 85: 1297-1311.
Online-Abstract

Bähr A, Singer A, Hain A, Vasudevan AA, Schilling M, Reh J, Riess M, Panitz S, Serrano V, Schweizer M, König R, Chanda S, Häussinger D, Kochs G, Lindemann D, Münk C (2016): Interferon but not MxB inhibits foamy retroviruses.
Virology 488: 51-60.
Online-Abstract

Ballmer-Weber BK, Brockow K, Fiocchi A, Theler B, Vogel L, Ring J, Szépfalusi Z, Mazzina O, Schaller R, Fritsché R, Vissers YM, Nutten S (2016): Hydrolysed egg displays strong decrease in allergenicity and is well-tolerated by egg allergic patients.
Allergy 71: 728-732.
Online-Abstract

Ballmer-Weber BK, Holzhauser T (2016): Bedeutung von Schwellenwerten bei Nahrungsmittelallergie.
Allergologie 39: 396-401.
Online-Abstract

Barthel SR, Medvedev R, Heinrich T, Büchner SM, Kettern N, Hildt E (2016): Hepatitis B virus inhibits insulin receptor signaling and impairs liver regeneration via intracellular retention of the insulin receptor.
Cell Mol Life Sci 73: 4121-4140.
Online-Abstract

Baylis SA, Corman VM, Ong E, Linnen JM, Nübling CM, Blümel J (2016): Hepatitis E viral loads in plasma pools for fractionation.
Transfusion 56: 2532-2537.
Online-Abstract

Beck S, Henß L, Weidner T, Herrmann J, Müller R, Chao YK, Grimm C, Weber C, Sliva K, Schnierle BS (2016): Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library.
Antiviral Res 132: 85-91.
Online-Abstract

Bekeredjian-Ding I (2016): Lieferengpässe bei Impfstoffen - Meldungen, Gründe und Auswirkungen.
Bulletin zur Arzneimittelsicherheit 7: 30-36.
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Bender RR, Muth A, Schneider IC, Friedel T, Hartmann J, Plückthun A, Maisner A, Buchholz CJ (2016): Receptor-targeted Nipah virus glycoproteins improve cell-type selective gene delivery and reveal a preference for membrane proximal cell attachment.
PLOS Pathog 12: e1005641.
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Bernau M, Kremer PV, Kreuzer LS, Emrich D, Pappenberger E, Cussler K, Hoffmann A, Leipig M, Hermanns W, Scholz AM (2016): Assessment of local reaction to vaccines in live piglets with magnetic resonance imaging compared to histopathology.
ALTEX 33: 29-36.
Online-Abstract

Bieber T, Vieths S, Broich K (2016): New opportunities and challenges in the assessment of drugs for atopic diseases.
Allergy 71: 1662-1665.
Online-Abstract

Blümel J, Brorson K (2016): Session 2: Company-Specific Data on Cycled Resin Testing.
PDA J Pharm Sci Technol 70: 428-442.
Online-Abstract

Blümel J, Musso D, Teitz S, Miyabayashi T, Boller K, Schnierle BS, Baylis SA (2016): Inactivation and removal of Zika virus during manufacture of plasma-derived medicinal products.
Transfusion 57: 790-796.
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Bock A, Schumann GG (2016): The Engineered SVA Trans-mobilization Assay.
Methods Mol Biol 1400: 203-222.
Online-Abstract

Bolton G, Blümel J (2016): Session 5: Conference Summary: Key Discussion and Outcomes, Pending Questions, and Proposed Experiments.
PDA J Pharm Sci Technol 70: 477-481.
Online-Abstract

Bonczkowski P, De Scheerder MA, Malatinkova E, Borch A, Melkova Z, König R, De Spiegelaere W, Vandekerckhove L (2016): Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models.
Sci Rep 6: 38329.
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Christians S, Schluender S, van Treel ND, Behr-Gross ME (2016): Interpretation of size-exclusion chromatography for the determination of molecular-size distribution of human immunoglobulins.
Pharmeur Bio Sci Notes 2016: 115-128.
Online-Abstract

Christians S, van Treel ND, Bieniara G, Eulig-Wien A, Hanschmann KM, Giess S (2016): Evaluation of capillary zone electrophoresis for the determination of protein composition in therapeutic immunoglobulins and human albumins.
Biologicals 44: 234-241.
Online-Abstract

Clarke DK, Hendry RM, Singh V, Rose JK, Seligman SJ, Klug B, Kochhar S, Mac LM, Carbery B, Chen RT, Brighton Collaboration Viral Vector Vaccines Safety Working Group (2016): Live virus vaccines based on a vesicular stomatitis virus (VSV) backbone: Standardized template with key considerations for a risk/benefit assessment.
Vaccine 34: 6597-6609.
Online-Abstract

Cozzi E, Tönjes RR, Gianello P, Bühler LH, Rayat GR, Matsumoto S, Park CG, Kwon I, Wang W, O'Connell P, Jessamine S, Elliott RB, Kobayashi T, Hering BJ (2016): First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 1: update on national regulatory frameworks pertinent to clinical islet xenotransplantation.
Xenotransplantation 23: 14-24.
Online-Abstract

da Fontoura Budaszewski R, von Messling V (2016): Morbillivirus Experimental Animal Models: Measles Virus Pathogenesis Insights from Canine Distemper Virus.
Viruses 8: E274.
Online-Abstract

Daumke O, Praefcke GJ (2016): Invited review: Mechanisms of GTP hydrolysis and conformational transitions in the dynamin superfamily.
Biopolymers 105: 580-593.
Online-Abstract

De Luca C, Guadagni F, Sinibaldi-Vallebona P, Sentinelli S, Gallucci M, Hoffmann A, Schumann GG, Spadafora C, Sciamanna I (2016): Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformation.
Oncotarget 7: 4048-4061.
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Denner J, Tönjes RR, Takeuchi Y, Fishman J, Scobie L (2016): First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Chapter 5: recipient monitoring and response plan for preventing disease transmission.
Xenotransplantation 23: 53-59.
Online-Abstract

Diebner HH, Kirberg J, Roeder I (2016): An evolutionary stability perspective on oncogenesis control in mature T-cell populations.
J Theor Biol 389: 88-100.
Online-Abstract

Dodt J, Pasternack R, Seitz R, Volkers P (2016): Free factor XIII activation peptide (fAP-FXIII) is a regulator of factor XIII activity via factor XIII-B.
Br J Haematol 172: 452-460.
Online-Abstract

Domanovic D, Kitchen A, Politis C, Panagiotopoulos T, Blümel J, Van Bortel W, Overbosch D, Lieshout-Krikke R, Fabra C, Facco G, Zeller H (2016): Targeting of blood safety measures to affected areas with ongoing local transmission of malaria.
Transfus Med 26: 1611-165.
Online-Abstract

Eichelberger M, Couzens M, Gao Y, Levine M, Katz J, Wagner R, Thompson C, Höschler K, Laurie K, Bai T, Engelhardt OG, Wood J, ELLA study participants (2016): Comparability of neuraminidase inhibition antibody titers measured by enzyme-linked lectin assay (ELLA) for the analysis of influenza vaccine immunogenicity.
Vaccine 34: 458-465.
Online-Abstract

El-Jade MR, Parcina M, Schmithausen RM, Stein C, Meilaender A, Hoerauf A, Molitor E, Bekeredjian-Ding I (2016): ESBL Detection: Comparison of a Commercially Available Chromogenic Test for Third Generation Cephalosporine Resistance and Automated Susceptibility Testing in Enterobactericeae.
PLOS ONE 11: e0160203.
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Elgner F, Donnerhak C, Ren H, Medvedev R, Schreiber A, Weber L, Heilmann M, Ploen D, Himmelsbach K, Finkernagel M, Klingel K, Hildt E (2016): Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus.
Biochem J 473: 145-155.
Online-Abstract

Elgner F, Ren H, Medvedev R, Ploen D, Himmelsbach K, Boller K, Hildt E (2016): The Intracellular Cholesterol Transport Inhibitor U18666A Inhibits the Exosome-Dependent Release of Mature Hepatitis C Virus.
J Virol 90: 11181-11196.
Online-Abstract

Engler H, Benson S, Wegner A, Spreitzer I, Schedlowski M, Elsenbruch S (2016): Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms.
Brain Behav Immun 52: 18-26.
Online-Abstract

Fettke F, Schumacher A, Canellada A, Toledo N, Bekeredjian-Ding I, Bondt A, Wuhrer M, Costa SD, Zenclussen AC (2016): Maternal and Fetal Mechanisms of B Cell Regulation during Pregnancy: Human Chorionic Gonadotropin Stimulates B Cells to Produce IL-10 While Alpha-Fetoprotein Drives Them into Apoptosis.
Front Immunol 7: 495.
Online-Abstract

Flory E, Riess M, Hein-Fuchs N, König R (2016): Aids: Scharade für das Immunsystem.
Dtsch Arztebl 113: A-1436 / B-1213 / C-1193.
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Fol R, Braudeau J, Ludewig S, Abel T, Weyer SW, Roederer JP, Brod F, Audrain M, Bemelmans AP, Buchholz CJ, Korte M, Cartier N, Müller UC (2016): Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model.
Acta Neuropathol 131: 247-266.
Online-Abstract

Friedel T, Jung-Klawitter S, Sebe A, Schenk F, Modlich U, Ivics Z, Schumann GG, Buchholz CJ, Schneider IC (2016): CD30 receptor-targeted lentiviral vectors for human induced pluripotent stem cell-specific gene modification.
Stem Cells Dev 25: 729-739.
Online-Abstract

Gabner S, Hlavaty J, Velde K, Renner M, Jenner F, Egerbacher M (2016): Inflammation-induced transgene expression in genetically engineered equine mesenchymal stem cells.
J Gene Med 18: 154-164.
Online-Abstract

Gabriel B, Fiebig U, Hohn O, Plesker R, Coulibaly C, Cichutek K, Mühlebach MD, Bannert N, Kurth R, Norley S (2016): Suppressing active replication of a live attenuated simian immunodeficiency virus vaccine does not abrogate protection from challenge.
Virology 489: 1-11.
Online-Abstract

Garrels W, Mukherjee A, Holler S, Cleve N, Talluri TR, Barg-Kues B, Diederich M, Köhler P, Petersen B, Lucas-Hahn A, Niemann H, Izsvák Z, Ivics Z, Kues WA (2016): Identification and re-addressing of a transcriptionally permissive locus in the porcine genome.
Transgenic Res 25: 63-70.
Online-Abstract

Garrels W, Talluri TR, Apfelbaum R, Carratalá YP, Bosch P, Pötzsch K, Grueso E, Ivics Z, Kues WA (2016): One-step Multiplex Transgenesis via Sleeping Beauty Transposition in Cattle.
Sci Rep 6: 21953.
Online-Abstract

Garrels W, Talluri TR, Ziegler M, Most I, Forcato DO, Schmeer M, Schleef M, Ivics Z, Kues W (2016): Cytoplasmic injection of murine zygotes with Sleeping Beauty transposon plasmids and minicircles results in the efficient generation of germline transgenic mice.
Biotechnol J 11: 178-184.
Online-Abstract

Giezen TJ, Avendaño-Solá C, Wolff-Holz E, Weise M, Ekman N, Laslop A, Breedveld F, Gomollón F, Puig L, Kurki P, Kvien TK, Thorpe R, Annese V (2016): Roundtable on biosimilars with European regulators and medical societies, Brussels, Belgium, 12 January 2016.
GaBi J 5: 74-83.
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Gogol-Döring A, Ammar I, Gupta S, Bunse M, Miskey C, Chen W, Uckert W, Schulz TF, Izsvák Z, Ivics Z (2016): Genome-Wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4+ T Cells.
Mol Ther 24: 592-606.
Online-Abstract

Goodman RE, Ebisawa M, Ferreira F, Sampson HA, van Ree R, Vieths S, Baumert JL, Bohle B, Lalithambika S, Wise J, Taylor SL (2016): AllergenOnline: A peer-reviewed, curated allergen database to assess novel food proteins for potential cross-reactivity.
Mol Nutr Food Res 60: 1183-1198.
Online-Abstract

Grabundzija I, Messing SA, Thomas J, Cosby RL, Bilic I, Miskey C, Gogol-Döring A, Kapitonov V, Gerhardt DJ, Diem T, Dalda A, Jurka J, Pritham EJ, Dyda F, Izsvák Z, Ivics Z (2016): A Helitron Transposon Resurrected From the Bat Genome Reveals a Novel Mechanism of Genome Shuffling in Eukaryotes.
Nat Commun 7: 10716.
Online-Abstract

Gräßel L, Fast LA, Scheffer KD, Boukhallouk F, Spoden GA, Tenzer S, Boller K, Bago R, Rajesh S, Overduin M, Berditchevski F, Florin L (2016): The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses.
Sci Rep 6: 32337.
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Gravanis I, Tzogani K, van Hennik P, de Graeff P, Schmitt P, Mueller-Berghaus J, Salmonson T, Gisselbrecht C, Laane E, Bergmann L, Pignatti F (2016): The European Medicines Agency Review of Brentuximab Vedotin (Adcetris) for the Treatment of Adult Patients With Relapsed or Refractory CD30+ Hodgkin Lymphoma or Systemic Anaplastic Large Cell Lymphoma: Summary of the Scientific Assessment of the Committee for Medicinal Products for Human Use.
Oncologist 21: 102-109.
Online-Abstract

Grimaldi C, Finco D, Fort MM, Gliddon D, Harper K, Helms WS, Mitchell JA, O'Lone R, Parish ST, Piche MS, Reed DM, Reichmann G, Ryan PC, Stebbings R, Walker M (2016): Cytokine release: A workshop proceedings on the state-of-the-science, current challenges and future directions.
Cytokine 85: 101-108.
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Guo H, König R, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefood B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM, Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK, Ting JPY (2016): NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.
Cell Host & Microbe 19: 515-528.
Online-Abstract

Gupta S, Biswas A, Akhter MS, Krettler C, Reinhart C, Dodt J, Reuter A, Philippou H, Ivaskevicius V, Oldenburg J (2016): Revisiting the mechanism of coagulation factor XIII activation and regulation from a structure/functional perspective.
Sci Rep 6: 30105.
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Hanauer JR, Gottschlich L, Riehl D, Rusch T, Koch V, Friedrich K, Hutzler S, Prüfer S, Friedel T, Hanschmann KM, Münch RC, Jost C, Plückthun A, Cichutek K, Buchholz CJ, Mühlebach MD (2016): Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors.
Mol Ther Oncolytics 3: 16003.
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Hayakawa T, Harris I, Joung J, Kanai N, Kawamata S, Kellathur S, Koga J, Lin YC, Maruyama Y, McBlane J, Nishimura T, Renner M, Ridgway A, Salmikangas P, Sakamoto N, Sato D, Sato Y, Toda Y, Umezawa A, Werner M, Wicks S (2016): Report of the International Regulatory Forum on Human Cell Therapy and Gene Therapy Products.
Biologicals 44: 467-479.
Online-Abstract

He L, Bardiaux B, Ahmed M, Spehr J, König R, Lünsdorf H, Rand U, Lührs T, Ritter C (2016): Structure determination of helical filaments by solid-state NMR spectroscopy.
Proc Natl Acad Sci U S A 113: E272-E281.
Online-Abstract

Henß L, Beck S, Weidner T, Biedenkopf N, Sliva K, Weber C, Becker S, Schnierle BS (2016): Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry.
Virol J 13: 149.
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Heymans L, Mentzer D, Keller-Stanislawski B (2016): Verdachtsfälle unerwünschter Reaktionen nach Checkpoint-Inhibitoren aus Deutschland.
Bulletin zur Arzneimittelsicherheit 7: 11-18.
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Himly M, Nandy A, Kahlert H, Thilker M, Steiner M, Briza P, Angela N, Klysner S, van Ree R, Buchheit KH, Vieths S, Ferreira F (2016): Standardization of allergen products: 2. Detailed characterization of GMP-produced recombinant Phl p 5.0109 as European Pharmacopoeia reference standard.
Allergy 71: 495-504.
Online-Abstract

Hischebeth GT, Randau TM, Buhr JK, Wimmer MD, Hoerauf A, Molitor E, Bekeredjian-Ding I, Gravius S (2016): Unyvero i60 implant and tissue infection (ITI) multiplex PCR system in diagnosing periprosthetic joint infection.
J Microbiol Methods 121: 27-32.
Online-Abstract

Hischebeth GT, Randau TM, Molitor E, Wimmer MD, Hoerauf A, Bekeredjian-Ding I, Gravius S (2016): Comparison of bacterial growth in sonication fluid cultures with periprosthetic membranes and with cultures of biopsies for diagnosing periprosthetic joint infection.
Diagn Microbiol Infect Dis 84: 112-115.
Online-Abstract

Hoffmann OI, Kerekes A, Lipták N, Hiripi L, Bodo S, Szaloki G, Klein S, Ivics Z, Kues WA, Bosze Z (2016): Transposon-Based Reporter Marking Provides Functional Evidence for Intercellular Bridges in the Male Germline of Rabbits.
PLOS ONE 11: e0154489.
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Hoffmann A, Schwedinger E, Werner G, Cußler K (2016): Pharmakovigilanzreport Tierimpfstoffe: Analyse der Nebenwirkungsmeldungen im Jahr 2015.
DTBl: 1176-1178.
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Holzhauser T, Franke A, Treudler R, Schmiedeknecht A, Randow S, Becker WM, Lidholm J, Vieths S, Simon JC (2016): The BASALIT multicentre trial: Gly m 4 quantification for consistency control of challenge meal batches and towards Gly m 4 threshold data.
Mol Nutr Food Res 61: 1600527.
Online-Abstract

Husslik F, Nürnberg J, Seutter von Loetzen C, Mews T, Ballmer-Weber BK, Kleine-Tebbe J, Treudler R, Simon JC, Randow S, Völker E, Reuter A, Rösch P, Vieths S, Holzhauser T, Schiller D (2016): The conformational IgE epitope profile of soybean allergen Gly m 4.
Clin Exp Allergy 46: 1484-1497.
Online-Abstract

Idelevich EA, Büsing M, Mischnik A, Kaase M, Bekeredjian-Ding I, Becker K (2016): False non-susceptible results of tigecycline susceptibility testing against Enterobacteriaceae by an automated system: a multicentre study.
J Med Microbiol 65: 877-881.
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Ivics Z (2016): Endogenous Transposase Source in Human Cells Mobilizes piggyBac Transposons.
Mol Ther 24: 851-854.
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Jaeger H, Roth A, Toepfl S, Holzhauser T, Engel KH, Knorr D, Vogel R, Bandick N, Kulling S, Heinz V, Steinberg P (2016): Opinion on the use of ohmic heating for the treatment of foods.
Trends Food Sci Tech 55: 84-97.
Online-Abstract

Jungbäck C, Buchheit KH, Kulcsar G, Motitschke A, Ottiger HP, Parker R, Milne C (2016): Benefits of official batch control and surveillance for immunological VMPs.
Regulatory Rapporteur 13: 7-13.
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Kaufmann E, Spohr C, Battenfeld S, De Paepe D, Holzhauser T, Balks E, Homolka S, Reiling N, Gilleron M, Bastian M (2016): BCG Vaccination Induces Robust CD4+ T Cell Responses to Mycobacterium tuberculosis Complex-Specific Lipopeptides in Guinea Pigs.
J Immunol 196: 2723-2732.
Online-Abstract

Kaul S, Zimmer J, Dehus O, Costanzo A, Daas A, Buchheit KH, Asturias JA, Barber D, Carnés J, Chapman M, Dayan-Kenigsberg J, Döring S, Führer F, Hanschmann KM, Holzhauser T, Ledesma A, Moingeon P, Nony E, Pini C, Plunkett G, Reese G, Sandberg E, Sander I, Strecker D, Valerio C, van Ree R, Vieths S (2016): Standardization of allergen products: 3. validation of candidate european pharmacopoeia standard methods for quantification of major birch allergen bet v 1.
Allergy 71: 1414-1424.
Online-Abstract

Keipert C, Hilger A (2016): Response to Italian registries on bleeding disorders.
Clin Pharmacol Ther 99: 273.

Keipert C, van den Berg HM, Keller-Stanislawski B, Hilger A (2016): Haemophilia registries to complement clinical trial data: a pious hope or an urgent necessity? Reflections on a possible way forward.
Haemophilia 22: 647-650.
Online-Abstract

Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Canadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG (2016): Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Nat Commun 7: 10286.
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Klug B, Robertson JS, Condit RC, Seligman SJ, Laderoute MP, Sheets R, Williamson AL, Gurwith M, Kochhar S, Chapman L, Carbery B, Mac LM, Chen RT, Brighton Collaboration Viral Vaccine Vector Safety Working Group (2016): Adventitious agents and live viral vectored vaccines: Considerations for archiving samples of biological materials for retrospective analysis.
Vaccine 34: 6617-6625.
Online-Abstract

Kochs G, Anzaghe M, Kronhart S, Wagner V, Gogesch P, Scheu S, Lienenklaus S, Waibler Z (2016): In Vivo Conditions Enable IFNAR-Independent Type I Interferon Production by Peritoneal CD11b+ Cells upon Thogoto Virus Infection.
J Virol 90: 9330-9337.
Online-Abstract

Köberle U, Stammschulte T, Teipel A, Vogel HP, Peter HH, Keller-Stanislawski B, Gundert-Remy U (2016): Meningoenzephalitis durch Epstein-Barr-Virus (EBV) nach Therapie mit Adalimumab bei einer Patientin mit rheumatoider Arthritis.
Bulletin zur Arzneimittelsicherheit 7: 15-18.
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Kosack CS, Nick S (2016): Evaluation of two rapid screening assays for detecting hepatitis C antibodies in resource-constrained settings.
Trop Med Int Health 21: 603-609.
Online-Abstract

Kuhlmann N, Wroblowski S, Knyphausen P, de Boor S, Brenig J, Zienert AY, Meyer-Teschendorf K, Praefcke GJ, Nolte H, Krüger M, Schacherl M, Baumann U, James LC, Chin JW, Lammers M (2016): Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation.
J Biol Chem 291: 5484-5499.
Online-Abstract

Kumar A, Abbas W, Colin L, Khan KA, Bouchat S, Varin A, Larbi A, Gatot JS, Kabeya K, Vanhulle C, Delacourt N, Pasquereau S, Coquard L, Borch A, König R, Clumeck N, De Wit S, Rohr O, Rouzioux C, Fulop T, Van Lint C, Herbein G (2016): Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.
Sci Rep 6: 24090.
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Lehmann MH, Torres-Domínguez LE, Price PJ, Brandmüller C, Kirschning CJ, Sutter G (2016): CCL2 expression is mediated by type I IFN receptor and recruits NK and T cells to the lung during MVA infection.
J Leukoc Biol 99: 1057-1064.
Online-Abstract

Lötzsch B, Dölle S, Vieths S, Worm M (2016): Exploratory analysis of CD63 and CD203c expression in basophils from hazelnut sensitized and allergic individuals.
Clin Transl Allergy 6: 45.
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Marino D, Perković M, Hain A, Jaguva Vasudevan AA, Hofmann H, Hanschmann KM, Mühlebach MD, Schumann GG, König R, Cichutek K, Häussinger D, Münk C (2016): APOBEC4 Enhances the Replication of HIV-1.
PLOS ONE 11: e0155422.
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Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilò MB, Blank S, Bohle B, Bosshard PP, Breiteneder H, Brough HA, Caraballo L, Caubet JC, Crameri R, Davies JM, Douladiris N, Ebisawa M, Elgenmann PA, Fernandez-Rivas M, Ferreira F, Gadermaier G, Glatz M, Hamilton RG, Hawranek T, Hellings P, Hoffmann-Sommergruber K, Jakob T, Jappe U, Jutel M, Kamath SD, Knol EF, Korosec P, Kuehn A, Lack G, Lopata AL, Mäkelä M, Morisset M, Niederberger V, Nowak-Węgrzyn AH, Papadopoulos NG, Pastorello EA, Pauli G, Platts-Mills T, Posa D, Poulsen LK, Raulf M, Sastre J, Scala E, Schmid JM, Schmid-Grendelmeier P, van Hage M, van Ree R, Vieths S, Weber R, Wickman M, Muraro A, Ollert M (2016): EAACI Molecular Allergology User's Guide.
Pediatr Allergy Immunol Suppl 23: 1-250.
Online-Abstract

Medvedev R, Hildt E, Ploen D (2016): Look who's talking-the crosstalk between oxidative stress and autophagy supports exosomal-dependent release of HCV particles.
Cell Biol Toxicol 33: 211-231.
Online-Abstract

Medvedev R, Ploen D, Hildt E (2016): HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis.
Oxid Med Cell Longev 2016: Article ID 9012580.
Online-Abstract

Memmer S, Weil S, Beyer S, Zöller T, Peters E, Hartmann J, Steinle A, Koch J (2016): The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex.
J Biol Chem 291: 25427-25438.
Online-Abstract

Mentzer D, Keller-Stanislawski B (2016): Daten zur Pharmakovigilanz von Impfstoffen aus dem Jahr 2014.
Bulletin zur Arzneimittelsicherheit 7: 12-19.
Text

Meyer TJ, Held U, Nevonen KA, Klawitter S, Pirzer T, Carbone L, Schumann GG (2016): The Flow of the Gibbon LAVA Element Is Facilitated by the LINE-1 Retrotransposition Machinery.
Genome Biol Evol 8: 3209-3225.
Online-Abstract

Moeschler S, Locher S, Conzelmann KK, Krämer B, Zimmer G (2016): Quantification of Lyssavirus-Neutralizing Antibodies Using Vesicular Stomatitis Virus Pseudotype Particles..
Viruses 8: E254.
Online-Abstract

Müller S, Funk MB, Keller-Stanislawski B (2016): Bewertung des gehäuften Auftretens eines posterioren reversiblen Enzephalopathie-Syndroms (PRES) unter intravenöser Immunglobulin(IVIG)-Therapie.
Bulletin zur Arzneimittelsicherheit 7: 20-25.
Text

Mukherjee A, Garrels W, Talluri TR, Tiedemann D, Bősze Z, Ivics Z, Kues WA (2016): Expression of Active Fluorophore Proteins in the Milk of Transgenic Pigs Bypassing the Secretory Pathway.
Sci Rep 6: 24464.
Text

Oberle D, Keller-Stanislawski B (2016): Kein Zusammenhang zwischen HPV-Impfung und dem Auftreten von multipler Sklerose.
Bulletin zur Arzneimittelsicherheit 7: 19-21.
Text

Oberle D, Pavel J, Keller-Stanislawski B (2016): Anaphylaxie nach Impfung von Kindern und Jugendlichen in Deutschland.
Bulletin zur Arzneimittelsicherheit 7: 30-42.
Text

Oberle D, Pavel J, Rieck T, Weichert S, Schroten H, Keller-Stanislawski B, Tenenbaum T (2016): Anaphylaxis Following Immunization of Children and Adolescents in Germany.
Pediatr Infect Dis 35: 535-541.
Online-Abstract

Oelsner S, Wagner J, Friede ME, Pfirrmann V, Genßler S, Rettinger E, Buchholz CJ, Pfeifer H, Schubert R, Ottmann OG, Ullrich E, Bader P, Wels WS (2016): Chimeric antigen receptor-engineered cytokine-induced killer cells overcome treatment resistance of pre-B-cell acute lymphoblastic leukemia and enhance survival.
Int J Cancer 139: 1799-1809.
Online-Abstract

Pauli G, Aepfelbacher M, Bauerfeind U, Bekeredjian-Ding I, Blümel J, Burger R, Funk M, Gröner A, Gürtler L, Heiden M, Hildebrandt M, Jansen B, Offergeld R, Schlenkrich U, Schottstedt V, Seitz R, Stahl D, Strobel J, Willkommen H (2016): Zika Virus (ZIKV).
Transfus Med Hemother 43: 436-446.
Text

Pletz MW, Uebele J, Götz K, Hagel S, Bekeredjian-Ding I (2016): Vaccines against major ICU pathogens: where do we stand?.
Curr Opin Crit Care 22: 470-476.
Online-Abstract

Prax M, Mechler L, Weidenmaier C, Bertram R (2016): Glucose Augments Killing Efficiency of Daptomycin Challenged Staphylococcus aureus Persisters.
PLOS ONE 11: e0150907.
Online-Abstract

Quick J, Loman NJ, Duraffour S, Simpson JT, Severi E, Cowley L, Bore JA, Koundouno R, Dudas G, Mikhail A, Quédraogo N, Afrough B, Bah A, Baum JH, Becker-Ziaja B, Boettcher JP, Cabeza-Cabrerizo M, Camino-Sánchez Á, Carter LL, Doerrbecker J, Enkirch T, García-Dorival I, Hetzelt N, Hinzmann J, Holm T, Kafetzopoulou LE, Koropogui M, Kosgey A, Kuisma E, Logue CH, Mazzarelli A, Meisel S, Mertens M, Michel J, Ngabo D, Nitzsche K, Pallasch E, Patrono LV, Portmann J, Repits JG, Rickett NY, Sachse A, Singethan K, Vitoriano I, Yemanaberhan RL, Zekeng EG, Racine T, Bello A, Sall AA, Faye O, Magassouba N, Williams CV, Amburgey V, Winona L, Davis E, Gerlach J, Washington F, Monteil V, Jourdain M, Bererd M, Camara A, Somlare H, Camara A, Gerard M, Bado G, Baillet B, Delaune D, Nebie KY, Diarra A, Savane Y, Pallawo RB, Gutierrez GJ, Milhano N, Roger I, Williams CJ, Yattara F, Lewandowski K, Taylor J, Rachwal P, Turner DJ, Pollakis G, Hiscox JA, Matthews DA, O'Shea MK, Johnston AM, Wilson D, Hutley E, Smit E, Di Caro A, Wölfel R, Stoecker K, Fleischmann E, Gabriel M, Weller SA, Koivogui L, Diallo B, Keita S, Rambaut A, Formenty P, Günther S, Carroll MW (2016): Real-time, portable genome sequencing for Ebola surveillance.
Nature 530: 228-232.
Online-Abstract

Rabenau HF, Schwebke, Blümel J, Eggers M, Rapp I, Steinmann J, Willkommen H (2016): 2. Mitteilung des DVV/GfV-Fachausschusses Virusdesinfektion zur DVV/RKI-Leitlinie in der Fassung vom 01.12.2014 : Erläuterung zur Bedeutung, Anwendung und Berechnung des "Large-Volume-Platings" (LVP).
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 59: 540-542.

Reichmann F, Pfitzner A, Rademacher G, Schwedinger E, Cussler K, Sauter-Louis CM (2016): Incidence of bovine neonatal pancytopenia in 243 farms in Germany.
BMC Vet Res 12: 220.
Online-Abstract

Ren H, Elgner F, Jiang B, Himmelsbach K, Medvedev R, Ploen D, Hildt E (2016): The Autophagosomal SNARE Protein Syntaxin 17 Is an Essential Factor for the Hepatitis C Virus Life Cycle.
J Virol 90: 5989-6000.
Text

Renner M, Anliker B, Flory E, Scherer J, Schüßler-Lenz M, Schweizer M, Ivics Z: Regulation for Gene and Cell Therapy Medicinal Products in Europe.
In: Terai S, Suda T (Hrsg.), Gene Therapy and Cell Therapy Through the Liver. Tokyo: Springer, 2016. S. 105-123, ISBN 978-4-431-55665-7

Ritter N, Schmalzing D, Ho K, Bishop J, Shahrokh Z, Rawat R, Sluzky V, Engelbergs J, Friedl E, Meiklejohn B (2016): Science, Risks, and Regulations: Current Perspectives on Host Cell Protein Analysis and Control.
BioProcess International 14: 40-51.
Text

Salge-Bartels U, Heiden M, Seitz R, Gieseler F (2016): PO-18 - Fibronectin EDA/EDB is expressed in adherent SCLC NCI-H69 cells and in pleural effusions of lung cancer patients: possible implication for drug resistance.
Thromb Res 140: 182-183.
Online-Abstract

Sawatsky B, Bente DA, Czub M, von Messling V (2016): Morbillivirus and henipavirus attachment protein cytoplasmic domains differently affect protein expression, fusion support and particle assembly.
J Gen Virol 97: 1066-1076.
Text

Schmid T, Gaede L, Böttcher K, Fichtner D, Beckmann R, Speck S, Becker F, Truyen U (2016): Efficacy assessment of three inactivated koi herpes virus antigen preparations against experimental challenge virus infection in common carp.
J Fish Dis 39: 1007-1013.
Online-Abstract

Schmidt R, Holznagel E, Neumann B, Alex N, Sawatsky B, Enkirch T, Pfeffermann K, Kruip C, von Messling V, Wagner R (2016): Squalene-containing licensed adjuvants enhance strain-specific antibody responses against the influenza hemagglutinin and induce subtype-specific antibodies against the neuraminidase.
Vaccine 34: 5329-5335.
Online-Abstract

Schülke S, Scheurer S (2016): Immunologische Grundlagen und Pathomechanismen von Lebensmittelallergien.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 59: 723-731.
Online-Abstract

Schülke S, Vieths S (2016): Dendritic cell targeting with C-type lectins for improvement of allergen immunotherapy.
J Allergy Clin Immunol 138: 568-570.
Online-Abstract

Schülke S, Vogel L, Junker AC, Hanschmann KM, Flaczyk A, Vieths S, Scheurer S (2016): A Fusion Protein Consisting of the Vaccine Adjuvant Monophosphoryl Lipid A and the Allergen Ovalbumin Boosts Allergen-Specific Th1, Th2, and Th17 Responses In Vitro.
J Immunol Res 2016: 1-8.
Online-Abstract

Schüssler-Lenz M, Beuneu C, Menezes-Ferreira M, Jekerle V, Bartunek J, Chamuleau S, Celis P, Doevendans P, O'Donovan M, Hill J, Hystad M, Jovinge S, Kyselovic J, Lipnik-Stangelj M, Maciulaitis R, Prasad K, Samuel A, Tenhunen O, Tonn T, Rosano G, Zeiher A, Salmikangas P (2016): Cell-based therapies for cardiac repair: a meeting report on scientific observations and European regulatory viewpoints.
Eur J Heart Fail 18: 133-141.
Online-Abstract

Schütz C, Varela JC, Perica K, Haupt C, Oelke M, Schneck JP (2016): Antigen-specific T cell Redirectors: a nanoparticle based approach for redirecting T cells.
Oncotarget 7: 68503-68512.
Online-Abstract

Sebe A, Ivics Z (2016): Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells with Sleeping Beauty Transposon-Based Stable Gene Delivery.
Methods Mol Biol 1400: 419-427.
Online-Abstract

Sommer AFR, Rivière L, Qu B, Schott K, Riess M, Ni Y, Shepard C, Schnellbächer E, Finkernagel M, Himmelsbach K, Welzel K, Kettern N, Donnerhak C, Münk C, Flory E, Liese J, Kim B, Urban S, König R (2016): Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Sci Rep May 27 [Epub ahead of print].
Text

Stern D, Olson VA, Smith SK, Pietraszczyk M, Miller L, Miethe P, Dorner BG, Nitsche A (2016): Rapid and sensitive point-of-care detection of Orthopoxviruses by ABICAP immunofiltration.
Virol J 13: 207.
Online-Abstract

Streit R, Rocha F, Mentzer D, Keller-Stanislawski B (2016): Schulterverletzung nach Impfung (SIRVA).
Bulletin zur Arzneimittelsicherheit 7: 10-14.
Text

Tasew G, Gadisa E, Abera A, Zewude A, Chanyalew M, Aseffa A, Abebe M, Ritter U, van Zandbergen G, Laskay T, Tafess K (2016): In vitro permissiveness of bovine neutrophils and monocyte derived macrophages to Leishmania donovani of Ethiopian isolate.
Parasit Vectors 9: 218.
Text

Thomas A, Biswas A, Dodt J, Philippou H, Hethershaw E, Ensikat HJ, Ivaskevicius V, Oldenburg J (2016): Coagulation Factor XIIIA Subunit Missense Mutations Affect Structure and Function at the Various Steps of Factor XIII Action.
Hum Mutat 37: 1030-1041.
Online-Abstract

Treudler R, Franke A, Schmiedeknecht A, Ballmer-Weber BK, Worm M, Werfel T, Jappe U, Biedermann T, Schmitt J, Brehler R, Kleinheinz A, Kleine-Tebbe J, Brüning H, Ruëff F, Ring J, Saloga J, Schäkel K, Holzhauser T, Vieths S, Simon JC (2016): Standardization of double blind placebo controlled food challenge with soy within a multicentre trial.
Clin Transl Allergy 6: 39.
Text

Trösemeier JH, Musso D, Blümel J, Théze J, Pybus OG, Baylis SA (2016): Genome Sequence of a Candidate World Health Organization Reference Strain of Zika Virus for Nucleic Acid Testing.
Genome Announc 4: e00917-16.
Text

Vannice KS, Giersing BK, Kaslow DC, Griffiths E, Meyer H, Barrett A, Durbin AP, Wood D, Hombach J (2016): Meeting Report: WHO consultation on considerations for regulatory expectations of Zika virus vaccines for use during an emergency.
Vaccine Dec 1 [Epub ahead of print].
Online-Abstract

Voigt F, Wiedemann L, Zuliani C, Querques I, Sebe A, Mátés L, Izsvák Z, Ivics Z, Barabas O (2016): Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
Nat Commun 7: 11126.
Online-Abstract

Volz-Zang C, Keller-Stanislawski B (2016): Aktualisierte Empfehlungen zur Minimierung des Risikos einer PML unter Tysabri-Behandlung.
Bulletin zur Arzneimittelsicherheit 7: 11-20.
Text

Volz-Zang C, Waibler Z (2016): Sicherheit bei First-in-Man-Studien - In-vitro- und In-vivo-Forschung zur immunologischen Wirkung von TGN1412 und anderen monoklonalen Superagonisten.
Bulletin zur Arzneimittelsicherheit 7: 37-40.
Text

von Rhein C, Weidner T, Henß L, Martin J, Weber C, Sliva K, Schnierle BS (2016): Curcumin and Boswellia serrata gum resin extract inhibit chikungunya and vesicular stomatitis virus infections in vitro.
Antiviral Res 125: 51-57.
Online-Abstract

Waisman A, Hövelmeyer N, Diefenbach A, Schuppan D, Reddehase MJ, Kleinert H, Kaina B, Grabbe S, Galle PR, Theobald M, Zipp F, Sahin U, Türeci Ö, Kreiter S, Langguth P, Decker H, van Zandbergen G, Schild H (2016): Past, present and future of immunology in Mainz.
Cell Immunol 308: 1-6.

Waller T, Götz K, Spreitzer I, Bekeredjian-Ding I (2016): Immunmodulatorische Wirkung von Outer Membrane Vesicles - Stand der Forschung und Implikationen für die Arzneimittelsicherheit.
Bulletin zur Arzneimittelsicherheit 7: 30-34.
Text

Waller T, Kesper L, Hirschfeld J, Dommisch H, Kölpin J, Oldenburg J, Uebele J, Hoerauf A, Deschner J, Jepsen S, Bekeredjian-Ding I (2016): Porphyromonas gingivalis Outer Membrane Vesicles Induce Selective Tumor Necrosis Factor Tolerance in a Toll-Like Receptor 4- and mTOR-Dependent Manner.
Infect Immun 84: 1194-1204.
Text

Wang J, Singh M, Sun C, Besser D, Prigione A, Ivics Z, Hurst LD, Izsvák Z (2016): Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Nat Protoc 11: 327-346.
Online-Abstract

Wangorsch A, Larsson H, Messmer M, García-Moral A, Lauer I, Wolfheimer S, Schülke S, Bartra J, Vieths S, Lidholm J, Scheurer S (2016): Molecular cloning of plane pollen allergen Pla a 3 and its utility as diagnostic marker for plane pollen associated peach allergy.
Clin Exp Allergy 46: 764-774.
Online-Abstract

Weise M, Wolff-Holz E (2016): Möglichkeiten und Herausforderungen der Extrapolation bei Biosimilars.
Z Gastroenterol 54: 1211-1216.
Online-Abstract

Weißmüller S, Kronhart S, Kreuz D, Schnierle B, Kalinke U, Kirberg J, Hanschmann KM, Waibler Z (2016): TGN1412 induces lymphopenia and human cytokine release in a humanized mouse model.
PLOS ONE 9: e0149093.
Online-Abstract

Wild E, Bonifas U, Klimek J, Trösemeier JH, Krämer B, Kegel B, Behrensdorf-Nicol HA (2016): In vitro potency determination of botulinum neurotoxin B based on its receptor-binding and proteolytic characteristics.
Toxicol In Vitro 34: 97-104.
Online-Abstract

Wilkinson DE, Seiz PL, Schüttler CG, Gerlich WH, Glebe D, Scheiblauer H, Nick S, Chudy M, Dougall T, Stone L, Heath AB, Collaborative Study Group (2016): International collaborative study on the 3rd WHO International Standard for hepatitis B surface antigen.
J Clin Virol 82: 173-180.
Text

Willkommen H, Blümel J, Brorson K, Chen D, Chen Q, Groener A, Kreil T, Ruffing M, Ruiz S, Scott D, Silvester G (2016): Meeting Report: 2015 PDA Virus & TSE Safety Forum.
PDA J Pharm Sci Technol 70: 177-188.
Online-Abstract

Worm M, Vieths S (2016): Editorial zum Schwerpunktheft Lebensmittelallergien und andere Lebensmittelunverträglichkeiten.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 59: 703-704.

Worm M, Vieths S (2016): Editorial zum Schwerpunktheft Lebensmittelallergien und andere Lebensmittelunverträglichkeiten (Teil 2).
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 59: 819-820.
Online-Abstract

Zhang Z, Gu Q, Jaguva Vasudevan AA, Jeyaraj M, Schmidt S, Zielonka J, Perkovic M, Heckel JO, Cichutek K, Häussinger D, Smits SH, Münk C (2016): Vif Proteins from Diverse Human Immunodeficiency Virus/Simian Immunodeficiency Virus Lineages Have Distinct Binding Sites in A3C.
J Virol 90: 10193-10208.
Online-Abstract

Zhang Z, Gu Q, Jaguva Vasudevan AA, Hain A, Kloke BP, Hasheminasab S, Mulnaes D, Sato K, Cichutek K, Häussinger D, Bravo IG, Smits SH, Gohlke H, Münk C (2016): Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors.
Retrovirology 13: 46.
Text

Zhang W, Li L, Deng X, Blümel J, Nübling CM, Hunfeld A, Baylis SA, Delwart E (2016): Viral nucleic acids in human plasma pools.
Transfusion 56: 2248-2255.
Online-Abstract

Zimmer J, Vieths S, Kaul S (2016): Standardization and Regulation of Allergen Products in the European Union.
Curr Allergy Asthma Rep 16: 21.
Online-Abstract