Please note: Authors from the Paul-Ehrlich-Institut are highlighted in bold. For online abstracts or full text publications, please follow the links.
Gogesch P, Ortega Iannazzo S, Zimmermann T, Villenave R, Waibler Z (2024): Analyzing IL-2-induced vascular leakage with an irAOP as tool.
J Immunotoxicol Dec 10 [Epub ahead of print].
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Mazein A, Shoaib M, Alb M2, Sakellariou C, Sommer C, Sewald K, Reiche K, Gogesch P, Roser LA, Ortega Iannazzo S, Sheth S, Schiffmann S, Waibler Z, Neuhaus V, Dehmel S, Satagopam V, Schneider R, Ostaszewski M, Gu W (2024): Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways.
J Immunotoxicol 21: S5-S12.
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Roser LA, Sommer C, Ortega Iannazzo S, Sakellariou C, Waibler Z, Gogesch P (2024): Revival of recombinant IL-2 therapy – approaches from the past until today.
J Immunotoxicol Dec 10 [Epub ahead of print].
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Waibler Z, Anzaghe M, Gogesch P: Impfimmunologie.
In: Oberle D, Cichutek K, Wichmann O (Hrsg.), Impfen kompakt: fundierte Informationen aus dem Robert Koch-Institut und dem Paul-Ehrlich-Institut. 1. Aufl.: Urban & Fischer Verlag/Elsevier GmbH, 2024. 27-34 ISBN 978-3-437-23540-5
Ringler E, Ortega Iannazzo S, Herzig J, Weiss LM, Anzaghe M, Miller L, Waibler Z (2023): Complement protein C3a enhances adaptive immune responses towards FVIII products.
Haematologica 108: 1579-1589.
Online-Abstract
Ebenig A, Muraleedharan S, Kazmierski J, Todt D, Auste A, Anzaghe M, Gömer A, Postmus D, Gogesch P, Niles M, Plesker R, Miskey C, Gellhorn Serra M, Breithaupt A, Hörner C, Kruip C, Ehmann R, Ivics Z, Waibler Z, Pfaender S, Wyler E, Landthaler M, Kupke A, Nouailles G, Goffinet C, Brown RJP, Mühlebach MD (2022): Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after TH2-biased immunization.
Cell Rep 40: 111214.
Online-Abstract
Krauter S, Buescher N, Bräuchle E, Ortega Iannazzo S, Penner I, Krämer N, Gogesch P, Thomas S, Kreutz M, Dejung M, Freiwald A, Butter F, Waibler Z, Plachter B (2022): An Attenuated Strain of Human Cytomegalovirus for the Establishment of a Subviral Particle Vaccine.
Vaccines (Basel) 10: 1326.
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Miller L, Waibler Z, Regourd E, Jouette S (2022): Collaborative study for the establishment of Human immunoglobulin for anticomplementary activity BRP replacement batches 3, 4, 5 and 6.
Pharmeur Bio Sci Notes 2022: 10-21.
Online-Abstract
Anzaghe M, Kronhart S, Niles MA, Höcker L, Dominguez M, Kochs G, Waibler Z (2021): Type I interferon receptor-independent interferon-α induction upon infection with a variety of negative-strand RNA viruses.
J Gen Virol 102: 001616.
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Gogesch P, Dudek S, van Zandbergen G, Waibler Z, Anzaghe M (2021): The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies.
Int J Mol Sci 22: 8947.
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Niles MA, Gogesch P, Kronhart S, Ortega Iannazzo S, Kochs G, Waibler Z, Anzaghe M (2021): Macrophages and dendritic cells are not the major source of pro-inflammatory cytokines upon SARS-CoV-2 infection.
Front Immunol 12: 647824.
Online-Abstract
Borst K, Flindt S, Blank P, Larsen PK, Chhatbar C, Skerra J, Spanier J, Hirche C, König M, Alanentalo T, Hafner M, Waibler Z, Pfeffer K, Sexl V, Sutter G, Müller W, Graalmann T, Kalinke U (2020): Selective reconstitution of IFN‑γ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection.
PLoS Pathog 16: e1008279.
Online-Abstract
Anzaghe M, Resch T, Schaser E, Kronhart S, Diez C, Niles MA, Korotkova E, Schülke S, Wolfheimer S, Kreuz D, Wingerter M, Bartolomé Rodríguez MM, Waibler Z (2019): Organ-specific expression of IL-1 receptor results in severe liver injury in type I interferon receptor deficient mice.
Front Immunol 10: 1009.
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Dudek S, Weißmüller S, Anzaghe M, Miller L, Sterr S, Hoffmann K, Hengel H, Waibler Z (2019): Human Fcγ receptors compete for TGN1412 binding which determines the antibody's effector function.
Eur J Immunol 49: 1117-1126.
Online-Abstract
Miller L, Klemm J, Schmidt C, KM Hanschmann, Bekeredjian-Ding I, Waibler Z (2019): Individual combinations of danger signals synergistically increase FVIII product immunogenicity.
Haemophilia 25: 996-1002.
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Arens K, Filippis C, Kleinfelder H, Goetzee A, Crauwels P, Reichmann G, Waibler Z, Bagola K, van Zandbergen G (2018): Anti-Tumor Necrosis Factor α Therapeutics Differentially Affect Leishmania Infection of Human Macrophages.
Front Immunol 9: Article 1772.
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Gogesch P, Schülke S, Scheurer S, Mühlebach MD, Waibler Z (2018): Modular MLV-VLPs co-displaying ovalbumin peptides and GM-CSF effectively induce expansion of CD11b+ APC and antigen-specific T cell responses in vitro.
Mol Immunol 101: 19-28.
Online-Abstract
Miller L, Ringler E, Kistner KM, Waibler Z, ABIRISK Consortium (2018): Human Dendritic Cells Synergistically Activated by FVIII Plus LPS Induce Activation of Autologous CD4+ T Cells.
Thromb Haemost 118: 688-699.
Online-Abstract
Bachmann M, Waibler Z, Pleli T, Pfeilschifter J, Mühl H (2017): Type I Interferon Supports Inducible Nitric Oxide Synthase in Murine Hepatoma Cells and Hepatocytes and during Experimental Acetaminophen-Induced Liver Damage.
Front Immunol 8: 890.
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Filippis C, Arens K, Noubissi Nzeteu GA, Reichmann G, Waibler Z, Crauwels P, van Zandbergen G (2017): Nivolumab Enhances In Vitro Effector Functions of PD-1+ T-Lymphocytes and Leishmania-Infected Human Myeloid Cells in a Host Cell-Dependent Manner.
Front Immunol 22: 1880.
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Kochs G, Anzaghe M, Kronhart S, Wagner V, Gogesch P, Scheu S, Lienenklaus S, Waibler Z (2016): In Vivo Conditions Enable IFNAR-Independent Type I Interferon Production by Peritoneal CD11b+ Cells upon Thogoto Virus Infection.
J Virol 90: 9330-9337.
Online-Abstract
Volz-Zang C, Waibler Z (2016): Sicherheit bei First-in-Man-Studien - In-vitro- und In-vivo-Forschung zur immunologischen Wirkung von TGN1412 und anderen monoklonalen Superagonisten.
Bulletin zur Arzneimittelsicherheit 7: 37-40.
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Weißmüller S, Kronhart S, Kreuz D, Schnierle B, Kalinke U, Kirberg J, Hanschmann KM, Waibler Z (2016): TGN1412 induces lymphopenia and human cytokine release in a humanized mouse model.
PLOS ONE 9: e0149093.
Online-Abstract
Malczyk AH, Kupke A, Prüfer S, Scheuplein VA, Hutzler S, Kreuz D, Beissert T, Bauer S, Hubich-Rau S, Tondera C, Shams Eldin H, Schmidt J, Vergara-Alert J, Süzer Y, Seifried J, Hanschmann KM, Kalinke U, Herold S, Sahin U, Cichutek K, Waibler Z, Eickmann M, Becker S, Mühlebach MD (2015): A highly immunogenic and protective MERS-Coronavirus vaccine based on recombinant MV vaccine platform.
J Virol 89: 11654-11667.
Online-Abstract
Miller L, Weißmüller S, Ringler E, Crauwels P, van Zandbergen G, Seitz R, Waibler Z, ABIRISK consortium (2015): Danger signal-dependent activation of human dendritic cells by plasma-derived factor VIII products.
Thromb Haemost 114: 268-276.
Online-Abstract
Ostermann E, Warnecke G, Waibler Z, Brune W (2015): Knockout of the host resistance gene Pkr fully restores replication of murine cytomegalovirus (MCMV) m142 and m143 mutants in vivo.
J Virol 90: 1144-1147.
Online-Abstract
Resch TK, Reichmann G, Waibler Z: Type I Interferons.
In: Parnham MJ (Hrsg.), Compendium of Inflammatory Diseases. Continuously updated edition, Basel: Springer, 2015. S. 1-8, ISBN 978-3-0348-0620-6 (Online)
Scheuplein VA, Seifried J, Malczyk AH, Miller L, Höcker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, König R, Becker S, Waibler Z, Mühlebach MD (2015): High secretion of interferons by human plasmacytoid dendritic cells upon recognition of MERS-CoV.
J Virol 89: 3859-3869.
Online-Abstract
Uhlig KM, Schülke S, Scheuplein VA, Malczyk AH, Reusch J, Kugelmann S, Muth A, Koch V, Hutzler S, Bodmer BS, Schambach A, Buchholz CJ, Waibler Z, Scheurer S, Mühlebach MD (2015): Lentiviral protein transfer vectors are an efficient vaccine-platform inducing strong antigen-specific cytotoxic T cell response.
J Virol 89: 9044-9060.
Online-Abstract
Conrad E, Resch TK, Gogesch P, Kalinke U, Bechmann I, Bogdan C, Waibler Z (2014): Protection against RNA-induced liver damage by myeloid cells requires type I interferon and IL-1 receptor antagonist in mice.
Hepatology 59: 1555-1563.
Online-Abstract
Schülke S, Wolfheimer S, Gadermaier G, Wangorsch A, Siebeneicher S, Briza P, Spreitzer I, Schiller D, Loeschner B, Uematsu S, Ryffel B, Akira S, Waibler Z, Vieths S, Toda M, Scheurer S (2014): Prevention of Intestinal Allergy in Mice by rflaA:Ova Is Associated with Enforced Antigen Processing and TLR5-Dependent IL-10 Secretion by mDC.
PLoS One 9: e87822.
Online-Abstract
Xu HC, Grusdat M, Pandyra AA, Polz R, Huang J, Sharma P, Deenen R, Köhrer K, Rahbar R, Diefenbach A, Gibbert K, Löhning M, Höcker L, Waibler Z, Häussinger D, Mak TW, Ohashi PS, Lang KS, Lang PA (2014): Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.
Immunity 40: 949-960.
Online-Abstract
Bohnen C, Wangorsch A, Schülke S, Nakajima-Adachi H, Hachimura S, Burggraf M, Süzer Y, Schwantes A, Sutter G, Waibler Z, Reese G, Toda M, Scheurer S, Vieths S (2013): Vaccination with recombinant modified vaccinia virus Ankara prevents the onset of intestinal allergy in mice.
Allergy 68: 1021-1028.
Online-Abstract
Büchner SM, Sliva K, Bonig H, Völker I, Waibler Z, Kirberg J, Schnierle BS (2013): Delayed onset of graft-versus-host disease in immunodeficent human leucocyte antigen-DQ8 transgenic, murine major histocompatibility complex class II-deficient mice repopulated by human peripheral blood mononuclear cells.
Clin Exp Immunol 173: 355-364.
Online-Abstract
Koch CP, Perna AM, Weißmüller S, Bauer S, Pillong M, Baleeiro RB, Reutlinger M, Folkers G, Walden P, Wrede P, Hiss JA, Waibler Z, Schneider G (2013): Exhaustive Proteome Mining for Functional MHC-I Ligands.
ACS Chem Biol 8: 1876-1881.
Online-Abstract
Zimmerling S, Waibler Z, Resch T, Sutter G, Schwantes A (2013): Interleukin-1beta receptor expressed by modified vaccinia virus Ankara interferes with interleukin-1beta activity produced in various virus-infected antigen-presenting cells.
Virol J 10: 34.
Online-Abstract
Geppert T, Bauer S, Hiss JA, Conrad E, Reutlinger M, Schneider P, Weisel M, Pfeiffer B, Altmann KH, Waibler Z, Schneider G (2012): Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions.
Angew Chem Int Ed Engl 51: 258-261.
Online-Abstract
Schmieder A, Schledzewski K, Michel J, Schönhaar K, Morias Y, Bosschaerts T, Van den Bossche J, Dorny P, Sauer A, Sticht C, Géraud C, Waibler Z, Beschin A, Goerdt S (2012): The CD20 homolog Ms4a8a integrates pro- and anti-inflammatory signals in novel M2-like macrophages and is expressed in parasite infection.
Eur J Immunol 42: 2971-2982.
Online-Abstract
Waibler Z, Seitz R (2012): Wie lassen sich Anti-Drug-Antikörper verhindern? EU-Forschungskonsortium mit Beteiligung des PEI.
Bulletin zur Arzneimittelsicherheit 3: 36-38.
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Weißmüller S, Semmler LY, Kalinke U, Christians S, Müller-Berghaus J, Waibler Z (2012): ICOS-LICOS interaction is critically involved in TGN1412-mediated T cell activation.
Blood 119: 6268-6277.
Online-Abstract
Grabski E, Waibler Z, Schüle S, Kloke BP, Sender LY, Panitz S, Cichutek K, Schweizer M, Kalinke U (2011): Comparative analysis of transduced primary human dendritic cells generated by the use of three different lentiviral vector systems.
Mol Biotechnol 47: 262-269.
Online-Abstract
Schülke S, Burggraf M, Waibler Z, Wangorsch A, Wolfheimer S, Kalinke U, Vieths S, Toda M, Scheurer S (2011): A fusion protein of flagellin and ovalbumin suppresses the TH2 response and prevents murine intestinal allergy.
J Allergy Clin Immunol 128: 1340-1348.
Online-Abstract
Buettner N, Vogt C, Martinez-Sobrido L, Weber F, Waibler Z, Kochs G (2010): Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor.
J Gen Virol 91: 220-227.
Online-Abstract
Frenz T, Waibler Z, Hofmann J, Hamdorf M, Lantermann M, Reizis B, Tovey MG, Aichele P, Sutter G, Kalinke U (2010): Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion.
Eur J Immunol 40: 2769-2777.
Online-Abstract
Ilchmann A, Burgdorf S, Scheurer S, Waibler Z, Nagai R, Wellner A, Yamamoto Y, Yamamoto H, Henle T, Kurts C, Kalinke U, Vieths S, Toda M (2010): Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: Role of macrophage scavenger receptor class A type I and II.
J Allergy Clin Immunol 125: 175-183.e11.
Online-Abstract
Kochs G, Bauer S, Vogt C, Frenz T, Tschopp J, Kalinke U, Waibler Z (2010): Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells.
J Virol 84: 12344-12350.
Online-Abstract
Murikinati S, Jüttler E, Keinert T, Ridder DA, Muhammad S, Waibler Z, Ledent C, Zimmer A, Kalinke U, Schwaninger M (2010): Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment.
FASEB J 24: 788-798.
Online-Abstract
Schülke S, Waibler Z, Mende S, Zoccatelli G, Vieths S, Toda M, Scheurer S (2010): Fusion protein of TLR5-ligand and allergen potentiates activation and IL-10 secretion in murine myeloid DC.
Mol Immunol 48: 341-350.
Online-Abstract
Sender LY, Gibbert K, Suezer Y, Radeke HH, Kalinke U, Waibler Z (2010): CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals.
Mol Immunol 47: 1255-1261.
Online-Abstract
Anz D, Thaler R, Stephan N, Waibler Z, Trauscheid MJ, Scholz C, Kalinke U, Barchet W, Endres S, Bourquin C (2009): Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus.
J Immunol 182: 6044-6050.
Online-Abstract
Dauber B, Martinez-Sobrido L, Schneider J, Hai R, Waibler Z, Kalinke U, Garcia-Sastre A, Wolff T (2009): Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR.
PLoS Pathog 5: e1000473.
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Essers MA, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA, Trumpp A (2009): IFNalpha activates dormant haematopoietic stem cells in vivo.
Nature 458: 904-908.
Online-Abstract
Ilchmann A, Burgdorf S, Scheurer S, Waibler Z, Nagai R, Wellner A, Yamamoto Y, Yamamoto H, Henle T, Kurts C, Kalinke U, Vieths S, Toda M (2009): Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II.
J Allergy Clin Immunol 125: 175-83.
Online-Abstract
Stockinger S, Kastner R, Kernbauer E, Pilz A, Westermayer S, Reutterer B, Soulat D, Stengl G, Vogl C, Frenz T, Waibler Z, Taniguchi T, Rülicke T, Kalinke U, Müller M, Decker T (2009): Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes.
PLoS Pathog 5: e1000355.
Volltext
Waibler Z, Anzaghe M, Frenz T, Schwantes A, Pöhlmann C, Ludwig H, Palomo-Otero M, Alcami A, Sutter G, Kalinke U (2009): Vaccinia virus-mediated inhibition of type I interferon responses is a multi-factorial process involving the soluble type I interferon receptor B18 and intracellular components.
J Virol 83: 1563-1571.
Online-Abstract
Waibler Z, Anzaghe M, Konur A, Akira S, Müller W, Kalinke U (2008): Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC.
Eur J Immunol 38: 3127-3137.
Online-Abstract
Waibler Z, Sender LY, Kamp C, Müller-Berghaus J, Liedert B, Schneider CK, Löwer J, Kalinke U (2008): Toward experimental assessment of receptor occupancy: TGN1412 revisited.
J Allergy Clin Immunol 122: 890-892.
Online-Abstract
Waibler Z, Sender LY, Merten C, Hartig R, Kliche S, Gunzer M, Reichardt P, Kalinke U, Schraven B (2008): Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.
PLoS ONE 3: e1708.
Online-Abstract
Demirel O, Waibler Z, Kalinke U, Grunebach F, Appel S, Brossart P, Hasilik A, Tampe R, Abele R (2007): Identification of a lysosomal peptide transport system induced during dendritic cell development.
J Biol Chem 282: 37836-37843.
Online-Abstract
Waibler Z, Anzaghe M, Ludwig H, Akira S, Weiss S, Sutter G, Kalinke U (2007): Modified vaccinia virus Ankara induces Toll-like receptor-independent type I interferon responses.
J Virol 81: 12102-12110.
Online-Abstract
Waibler Z, Detje CN, Bell JC, Kalinke U (2007): Matrix protein mediated shutdown of host cell metabolism limits vesicular stomatitis virus-induced interferon-alpha responses to plasmacytoid dendritic cells.
Immunobiology 212: 887-894.
Online-Abstract
Waibler Z, Kalinke U, Will J, Juan MH, Pfeilschifter JM, Radeke HH (2007): TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells.
Mol Immunol 44: 1483-1489.
Online-Abstract
Kamphuis E, Junt T, Waibler Z, Forster R, Kalinke U (2006): Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia.
Blood 108: 3253-3261.
Online-Abstract
Ludwig H, Süzer Y, Waibler Z, Kalinke U, Schnierle B, Sutter G (2006): Double stranded RNA-binding protein E3 controls translation of viral intermediate RNA marking an essential step in the life cycle of modified vaccinia virus Ankara.
J Gen Virol 87: 1145-1155.
Online-Abstract
Martin B, Schneider R, Janetzky S, Waibler Z, Pandur P, Kuhl M, Behrens J, von der Mark K, Starzinski-Powitz A, Wixler V (2002): The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts.
J Cell Biol 159: 113-122.
Volltext
Waibler Z, Starzinski-Powitz A (2002): Cadherins in skeletal muscle development.
Results Probl Cell Differ 38: 187-198.
Waibler Z, Schäfer A, Starzinski-Powitz A (2001): mARVCF cellular localisation and binding to cadherins is influenced by the cellular context but not by alternative splicing.
J Cell Sci 114: 3873-3884.
Volltext
Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (2000): The armadillo repeat region targets ARVCF to cadherin-based cellular junctions.
J Cell Sci 113: 4121-4135.
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