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Publications in 1998

Authors from the Paul-Ehrlich-Institut are highlighted in bold face type. Where online abstracts or full texts are available of the publications, there is a link to these texts.

Adorini L, Goldmann M, Kabelitz D, Revillard JP, Waldmann H (1998): Apoptosis, tolerance, and immunoregulation - Integrated pathways for immune system homeostasis.
The Immunologist 6: 92-94.

Arden B, Weber-Arden J, Wilbert OM, Kabelitz D (1998): TCRd rearrangement is confined to the proximal cluster of Va gene segments.
Immunobiol. 199: 469.

Baier M, Bannert N, Werner A, Adler HS, Otteken A, Beer B, Norley S, Kurth R (1998): Chemoattractant Factors and the Control of Human Immunodeficiency Virus Replication.
Pathobiology 66: 128-130.
Online-Abstract

Bannert N, Adler HS, Werner A, Baier M, Kurth R (1998): Molecular Cloning and Sequence Analysis of Interleukin 16 from Nonhuman Primates and from the Mouse.
Immunogenetics 47: 390-397.
Online-Abstract

Beer B, Denner J, Brown CR, Norley S, zur Megede J, Coulibaly C, Plesker R, Holzammer S, Baier M, Hirsch VM, Kurth R (1998): Simian Immunodeficiency Virus of African Green Monkeys is Apathogenic in the Newborn Natural Host.
JAIDS 18: 210-220.
Online-Abstract

Blum SA, Braunschweiger M, Krämer B, Rübmann P, Duchow K, Cußler K (1998): Nachweis der vollständigen Virusinaktivierung bei Tollwut-Impfstoffen. Ein in vivo- in vitro-Vergleich.
Altex 15: 46-49.
Online-Abstract

Buchholz CJ, Peng KW, Morling FJ, Zhang J, Cosset FL, Russell SJ (1998): In vivo selection of protease cleavage sites from retrovirus display libraries.
Nat Biotechnol 16: 951-954.
Online-Abstract

Conrad C, Kabelitz D, Schäffner G (1998): Wirksamkeitsprüfung von Antilymphozytenseren: Entwicklung von in vitro Methoden als Ersatz des Affenhaut-Transplantationstests.
Altex 15: 27-30.
Online-Abstract

Cußler K, Morton D, Hendriksen CFM (1998): Klinische Endpunkte als Ersatz für die Bestimmung der Letalistätsrate bei Tollwutinfektionsversuchen zur Impfstoffprüfung.
Altex 15: 40-42.
Online-Abstract

Dobmeyer TS, Dobmeyer JM, Klein SA, Wagner S, Helm EB, Hoelzer D, Rossol R, Kabelitz D (1998): Mechanism of gd T-cell mediated inhibition of stem cell differentiation in vitro: Possible relevance for myelosuppression in HIV-infected individuals.
Cell. Immunol 184: 26-36.
Online-Abstract

Dobmeyer TS, Klein SA, Dobmeyer JM, Raffel B, Markert BR, Hoelzer D, Helm EB, Rossol R, Kabelitz D (1998): Differential expression of bcl-2 and susceptibility to programmed cell death in lymphocytes of HIV-1 infected individuals.
Clin. Immunol. Immunopathol 87: 230-239.
Online-Abstract

Doll M , Salge U, Kleiner K, Lorenz M, Seitz R, Heiden M (1998): Oxidative alteration of blood coagulation in methylene blue-treated therapeutic plasma. 42nd Annual Meeting of the GTH, Frankfurt/Main, February 25-28.
Annals of Hematology 76: A64.

Ebert E, Abu Karim A, Kayser T, Wenig R, Weißer KM, Wirz M, Pisani G, Schäffner G, Cußler K (1998): Optimierung und Etablierung von serologischen Methoden für die Wirksamkeitsprüfung von Immunblobulinen gegen Clostridium tetani-Toxoid.
Altex 15: 30-32.
Online-Abstract

Ebert E, Öppling V, Werner E, Cußler K (1998): Development and prevalidation of alternative methods for the potency testing of C. perfringens vaccines.
Altex 15: 59-61.
Online-Abstract

Ebrecht A, Patscheke H (1998): Prevalence of blood coagulation factor V mutation LEIDEN in dependency of age, sex, D-Dimer concentration and the activities of AT III, Protein C and Protein S. 42nd Annual Meeting of the GTH, Frankfurt/Main, February 25-28.
Annals of Hematology 76: A78.

Eich S, Grundmann C, Seitz R, König H (1998): Highly sensitive in vitro assay for FVIIa: Application for the analysis of therapeutical blood products. 42nd Annual Meeting of the GTH, Frankfurt/Main, February 25-28.
Annals of Hematology 76: A50.

Etscheid M, Riesner D: TGGE and DGGE.
Karp A, Issac PG, Ingram DS (Hrsg.), Molecular Tools for Screening Biodiversity, Plants and animals London: Chapman and Hall, 1998. 135-151 ISBN 0-412-63830-4

Falkenbach A, Sedlmeyer A, Unkelbach U (1998): UVB radiation and its role in the treatment of postmenopausal women with osteoporosis.
Internat. J. of Biometeorology 41: 128.
Online-Abstract

Fennrich S, Fischer M, Hartung T, Lexa P, Montag-Lessing T, Sonntag HG, Weigandt M, Wendel A (1998): Evaluation and further development of a pyrogenicity assay based on human whole blood.
ALTEX 15: 123-128.
Online-Abstract

Fennrich S, Fischer M, Hartung T, Lexa P, Montag-Lessing T, Sonntag HG, Weigandt M, Wendel A (1999): Detection of endotoxins and other pyrogens using human whole blood.
Dev Biol Stand 101: 131-9.
Online-Abstract

Fischer M, Hartzsch K, Hartung T, Montag-Lessing T (1998): Erste Erfahrungen bei der Prävalidierung des Vollblutpyrogentests für biologische Arzneimittel.
Altex 15: 10-13.
Online-Abstract

Flory E, Weber C, Chen P, Hoffmeyer A, Jassoy C, Rapp UR (1998): Plasma membrane-targeted Raf Kinase Activates NF-kB and Human Immunodeficiency Virus -1 replication in T Lymphocytes.
J. Virol 72: 2788-2794.
Online-Abstract

Fötisch K, Fäh J, Wüthrich B, Altmann F, Haustein D, Vieths S (1998): IgE antibodies specific for carbohydrates in a patient allergic to gum arabic (Acacia senegal).
Allergy 53: 1043-1051.

Frey T, Ebrecht A, Neugebauer B, Schörner-Burkhardt E, Goy C, Budek I, Seitz R (1998): Characterisation of Coagulation Factor VIII-Concentrates with regard to integrity of Factor VIII and von Willebrand Factor (Intern. Congress of the World Federation of Hemophilia, Den Haag, 17.-20.05.98).
Haemophilia 4.

Hartinger J, Matheis W (1998): Steckbriefe immunologischer Adjuvantien: II Aluminium-Gele.
Der Tierschutzbeauftragte: 47-48.

Hartung T, Fennrich S, Fischer M, Montag-Lessing T, Wendel A (1998): Development and evaluation of a pyrogen test based on human whole blood.
ALTEX 15: 9-10.
Online-Abstract

Hauses M, Tönjes RR, Grez M (1998): The transcription factor Sp1 regulates the myeloid-specific expression of the human hematopoietic cell kinase (hck) gene through binding to two adjacent GC-boxes within the HCK promoter-proximal region.
J Biol Chem 273: 31844-31852.
Online-Abstract

Hinz T, Allam A, Wesch D, Schindler D, Kabelitz D (1998): Chimaeric T cell receptors in Ataxia telangiectasia patients and healthy individuals.
Immunobiol 199: 616-617.

Holst FGE, Hemmer CJ, Foth C, Seitz R, Egbring R, Dietrich M (1998): Low levels of Fibrin Stabilizing Factor (FactorXIII) in Human Plasmodium Falciparum Malaria correlate with clinical severirty.
Am J Trop Med Hyg.

Holzhauser T, Dehne LI, Hoffmann A, Haustein D, Vieths S (1998): Rocket immunoelectrophoresis (RIE) for determination of potentially allergenic peanut proteins in processed foods as a simple means for quality assurance and food safety.
Z Lebensm Unters Forsch A 206: 1-8.
Online-Abstract

Hunfeld A, Etscheid M, König H, Seitz R, Dodt J (1998): Identification of the thrombin-like activity of PCCs. 42nd Annual Meeting of the GTH, Frankfurt/Main, February 25-28.
Annals of Hematology 76: A101.

Jankiewicz A, Aulepp H, Altmann F, Fötisch K, Vieths S (1998): Serological investigation of 30 celery-allergic patients with particular consideration of the thermal stability of IgE binding celery allergens.
Allergo J 7: 87-95.

Johannes S, Rosskopf-Streicher U, Hausleithner D, Gyra H, Cussler K (1998): Proposal for a standard method for pig challenge tests with erysipelas strains.
Pharmeuropa BIO, Proceedings of the Symposium: Alternatives to animal test in the development and control of erysipelas vaccines, December 1998: 40-44.

Johannes S, Rosskopf-Streicher U, Hausleithner D, Gyra H, Cussler K: Use of clinical signs in efficacy testing of erysipelas vaccines.
In: Hendriksen CFM, Morton DB (eds.), Humane Endpoints in Animal Experiments for Biomedical Research: Proceedings of the International Conference, 22-25 November 1998 Zeist, Netherlands. London: The Royal Society of Medicine Press Limited, 1998. 102-105. ISBN 1-85315-429-6

Kabelitz D (1998): T-Lymphozyten bei der Immunabwehr.
Target Forum 1: 30-36.

Kabelitz D (1998): Apoptosis, graft rejection and transplantation tolerance.
Transplantation 65: 869-875.

Kastrati A, Schömig A, Elezi S, Schühlen H, Wilhelm MG, Dirschinger J (1998): Interlesion dependence of the risk for restenosis in patients with coronary stent placement in multiple lesions.
Circulation 97: 2396-2401.
Online-Abstract

Kaufmann SHE, Kabelitz D: The immune response to infectious agents.
Kaufmann SHE, KabelitzD (Hrsg.), Methods in Microbiology: Immunology of Infection London: Academic Press. 1-19 ISBN 0-12-521528-2

Kaul A, Nübling CM, Kempfer M, Schmidt I, Löwer J (1998): Entwicklung von molekularbiologischen Alternativmethoden zur Prüfung von Poliomyelitis-Impfstoffen.
ALTEX 15: 18-20.
Online-Abstract

Keller G, Rudelius M, Vogelsang H, Grimm V, Wilhelm MG, Mueller J, Siewert JR, Höfler H (1998): Microsatellite instability and loss of heterozygosity in gastric carcinoma in comparison to family history.
Am J Pathol 152: 1281-1289.
Online-Abstract

Klein K, Anduleit M, Bornhak M, Fischer M, Gross U, Löschner B, Nicol S, Reiter-Orwona I, Zyto N, Montag-Lessing T (1998): Vergleichende Charakterisierung von Toxoplasma gondii-Tachyzoiten aus unterschiedlichen Kultivierungsverfahren.
ALTEX 15: 37-39.
Online-Abstract

Krämer B, Rübmann PK, Duchow K, Cußler K (1998): Fremdvirusausschluß in Lebendimpfstoffen.
ALTEX 15: 43-45.
Online-Abstract

Kraft M, Filsinger S, Krämer KL, Kabelitz D, Hänsch GM, Schoels M (1998): Synovial fibroblasts as target cells for staphylococcal enterotoxin induced T-cell cytotoxicity.
Immunology 93: 20.
Online-Abstract

Kusch M, Rübmann P, Seitz R, König H (1998): Highly sensitive in vitro assay for FIXa: Its use in biochemical and molecular characterization. 42nd Annual Meeting of the GTH, Frankfurt/Main, February 25-28.
Annals of Hematology 76: A17.

Kusch M, Seitz R, König H (1998): Highly sensitive in vitro assay for FIXa II:Application for the analysis of therapeutical FIX concentrates. 42nd Annual Meeting of the GTH, Frankfurt/Main, February 25-28.
Ann Hematol 76: A51.

Kusch M, Seitz R, König H (1998): High Sensitivity Detection of Activated Factor IX: Application to the Analysis of Different Therapeutical Factor IX Concentrates and Prothrombin Complexes.
Thromb Haemost 79: 778-783.
Online-Abstract

Langhardt A, Frank L, Küchler B, Jungbäck C (1998): Die Aviäre Enzephalomyelitits des Huhnes: Beitrag zur Reduktion der Tierzahlen bei der Impfstoffprüfung.
ALTEX 15: 49-52.
Online-Abstract

Löwer R, Tönjes RR, Boller K, Denner J, Kaiser B, Phelps RC, Löwer J, Kurth R, Badenhoop K, Donner K, Usadsel KH, Miethke T, Lapatschek M, Wagner H (1998): Development of insulin-dependent diabetes mellitus does not depend on specific expression of the human endogenous retrovirus HERV-K.
Cell 95: 11-14.
Online-Abstract

Mühlhan P, Zweckstetter M, Georgescu J, Ciosto C, Renner C, Lanzendörfer M, Lang K, Ambrosius D, Baier M, Kurth R, Holak TA (1998): Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site.
Nature Structural Biology 5: 682-686.
Online-Abstract

Müller P, Dittmar MT, Beer B, König R, Plesker R, Norley S, Kurth R, Cichutek K (1998): Increased serum and mRNA levels of MIP-1b and RANTES associated with elevated levels of activated CD8+CD38+ T-cells in HIV-1 infected individuals.
Intervirology.

Müller U, Weber W, Hoffmann A, Franke S, Lange R, Vieths S (1998): Commercial soybean lecithins: A source of hidden allergens?.
Z Lebensm Unters Forsch A 207: 341-351.
Online-Abstract

Nübling CM, Gröner A, Löwer J (1998): GB Virus C / Hepatitis G Virus and intravenous immunoglobulins.
Vox Sanguinis 75: 189-192.
Online-Abstract

Neugebauer BM, Frey T, Seitz R, Budek I: Characterisation of Blood Clotting Factor VIII Concentrates.
In: Scharrer I, Schramm W (Hrsg.), 27. Hämophilie-Symposium Hamburg 1996. Berlin, Heidelberg: Springer, 1998. 293-302.

Neugebauer B, Nawrot R, Jescheck C, Budek I (1998): Overview of Blood Clotting Factor VIII (FVIII) Concentrates on the German Market. (Intern. Congress of the World Federation of Hemophilia, Den Haag, 17.-20.05.98).
Haemophilia 4.

Niggemann B, Kleine-Tebbe J, Saloga J, Sennekamp J, Vieluf J, Vieths S, Werfel T, Jäger L (1998): DGAI-Positionspapier: Standardisierung von oralen Provokationstests bei IgE-vermittelten Nahrungsmittelallergien.
Allergo J 7: 45-50.

Nilsson C, Makitalo B, Thorstensson R, Norley S, Binninger-Schinzel D, Cranage M, Rud E, Biberfeld G, Putkonen P (1998): Live Attenuated Simian Immunodeficiency Virus (SIV)mac in Macaques can Induce Protection Against Mucosal Infection with SIVsm.
AIDS 12: 2261-70.
Online-Abstract

Nübling CM (1998): HCV-NAT in der Transfusionsmedizin - Hintergrund, Anforderungen, Validierung.
Hygiene und Mikrobiologie 3: 9-11.

Nübling CM (1998): HCV-NAT in der Transfusionsmedizin - Hintergrund, Anforderungen, Validierung.
Hygiene und Mikrobiologie.

Nübling CM, Löwer J: GB-C / Hepatitis G Virus bei Hämophilen, Dialysepatienten, HIV-Infizierten und sein Nachweis in Blutprodukten.
Scharrer I, Schramm W (Hrsg.), 27. Hämophilie-Symposion Hamburg 1996 Berlin, Heidelberg: Springer, 1998. 47-53 ISBN 3-540-62915-7

Nübling CM, Seitz R, Löwer J (1998): Application of Nucleic Acid Amplification Techniques for Blood Donation Screening.
Infusion Therapy and Transfusion Medicin 25: 86-90.
Online-Abstract

Pechhold K, Kabelitz D: Measurement of cellular proliferation (3H-thymidine uptake, MTT, absolute cell numbers by SCDA).
Kaufmann SHE Kabelitz D (Hrsg.), Methods in Microbiology: Immunology of Infection: Academic Press, 1998. 59-78

Pößnecker A, Cußler K (1998): Untersuchungen zur Relevanz der Prüfung auf spezifische Unschädlichketi an der Zieltierspezies. Ergebnisse bei bakteriellen Impfstoffen im Zeitraum vno 1994-1997.
ALTEX 15: 71-75.
Online-Abstract

Revillard JP, Adorini L, Goldman M, Kabelitz D, Waldman H (1998): Apoptosis: Potential for disease therapies.
Immunol. Today 19: 291-293.
Online-Abstract

Rosskopf-Streicher U, Johannes S, Hausleithner D, Gyra H, Cussler K (1998): Suitability of an Elisa for the batch potency test in laboratory mice.
Pharmeuropa BIO 1: 65-70.

Rossol R, Dobmeyer JM, Dobmeyer TS, Klein SA, Rossol S, Wesch D, Hoelzer D, Kabelitz D, Helm EB (1998): Increase in Vd1+ gd T-cells in the peripheral blood and bone marrow as a selective feature of HIV-1 but not other virus infections.
Brit. J. Haematol 100: 728-34.
Online-Abstract

Salge U, Daubner E, Heiden M, Wilhelm M, Hommann M, Weinel W, Seitz R (1998): Studies on Coagulation and Fibrinolysis Markers in Patients with Hepato Cellular Carcinoma and Pancreatic Cancer. 42nd Annual Meeting of the GTH, Frankfurt/Main, February 25-28.
Annals of Hematology 76: A46.

Sanzenmacher R, Kabelitz D, Janssen O (1998): p56lck/SLP-76 complex formation and functional interaction in TCR desensitization and inhibition of AICD.
Immunobiol 199: 469.

Schulz H, Karau A, Filsinger S, Schoels M, Kabelitz D, Richter R, Hänsch GM (1998): Tubular epithelial cells as accessory cells for superantigen-induced T-cell activation.
Exp. Nephrol 6: 67-73.

Schwanig M (1998): Ersatzmethoden zum Tierversuch. Der lange Weg von der Entwicklung bis zur Arzneibuchmethode.
ALTEX 15: 6-9.
Online-Abstract

Seitz R, Burger R, Gerlich W, Gürtler L, Heiden M, Kretschmer V, Lefèvre H, Löwer J, Montag-Lessing T, Neumann R, Pauli G, Schlenkrich U, Werner E, Willkommen H, Schreier E, Nübling M (1998): GB-Virus Typ C (GBV-C), Andere Bezeichnung: Hepatitis-G-Virus (HGV).
Bundesgesundheitsbl. 41: 88-90.

Seitz R, Burger R, Gerlich W, Gürtler L, Heiden M, Kretschmer V, Lefèvre H, Löwer J, Montag-Lessing T, Neumann R, Pauli G, Schlenkrich U, Werner E, Willkommen H (1998): Humane T-Zell lmphotrophe Viruse Typ 1 und 2 (HTLV-I/-II).
Bundesgesundheitsbl 41: 512-517.

Seitz R, Burger R, Gerlich W, Gürtler L, Heiden M, Kretschmer V, Lefèvre H, Löwer J, Montag-Lessing T, Neumann R, Pauli G, Schlenkrich U, Werner E, Willkommen H (1998): Parvovirus B19.
Bundesgesundheitsbl. 41: 83-87.

Seitz R, Burger R, Gerlich W, Gürtler L, Heiden M, Kretschmer V, Lefèvre H, Löwer J, Montag-Lessing T, Neumann R, Pauli G, Schlenkrich U, Werner E, Willkommen H (1998): Creutzfeld-Jakob-Erkrankung (CJK) bzw. humane übertragbare (transmissible) spongiforme Enzephalopathien (TSE).
Bundesgesundheitsbl 41: 78-83.

Seitz R, Burger R, Gerlich W, Gürtler L, Heiden M, Kretschmer V, Lefèvre H, Löwer J, Montag-Lessing T, Neumann R, Pauli G, Schlenkrich U, Werner E, Willkommen H (1998): Parvovirus B19.
Infusther Transfusionsmed 25: 97-102.
Online-Abstract

Seitz R, Burger R, Gerlich W, Gürtler L, Heiden M, Kretschmer V, Lefèvre H, Löwer J, Montag-Lessing T, Neumann R, Pauli G, Schlenkrich U, Werner E, Willkommen H (1998): Creutzfeld-Jakob Disease and Human Transmissible Spongiform Encephalopathies.
Infusionsther Transfusionsmed 25: 89-96.

Seitz R, Burger R, Gerlich W, Gürtler L, Heiden M, Kretschmer V, Lefèvre H, Löwer J, Montag-Lessing T, Neumann R, Pauli G, Schlenkrich U, Werner E, Willkommen H (1998): GB-Virus Typ C (GBV-C), Alternative Denomination Hepatitis-G-Virus (HGV).
Infusther Transfsionsmed 25: 103-106.
Online-Abstract

Seitz R, Burger R (1998): Assessment of Pathogens Transmissible by Blood.
Infusionsther Transfusionsmed 25: 88.
Online-Abstract

Seitz R, Burger R (1998): Science, Lawyers and „the Europeans": Testing Requirements in Transfusion Medicine (Leserbrief).
Transfusion 38: 506-507.

Stitz J, Müller P, Cichutek K (1998): High-titer retroviral pseudotype vectors for specific targeting of human CD4-positive cells.
Biogenic Amines 14: 407-424.

Stöcker S, Heiden M, Seitz R (1998): Bluttransfusionen - Auf absehbare Zeit nicht zu ersetzen. (Leserbrief).
Dtsch Apoth Ztg 138.

Tönjes RR (1998): Diabetes und Superantigene.
Spektrum der Wissenschaft 2: 28-30.

Van Buul C, Cuypers H, Lelie P, Chudy M, Nübling CM, Melsert R, Oudshoorn P (1998): The NucliSenstm Extractor.
Infusionstherapie und Transfusionsmedizin 25: 147-151.

Vieths S, Frank E, Scheurer S, Meyer HE, Hrazdina G, Haustein D (1998): Characterisation of a new IgE-binding 35-kDa protein from birch pollen with cross-reacting homologues in various plant foods.
Scand J Immunol 47: 263-272.
Online-Abstract

Vieths S, Hoffmann A, Holzhauser T, Müller U, Reindl J, Haustein D (1998): Factors influencing the quality of food extracts for in vitro and in vivo diagnosis.
Allergy 53: 65-71.

Vieths S, Jankewiecz A, Holzhauser T: Charakterisierung von Allergenen und Nachweis potentiell allergener Bestandteile in verarbeiteten Lebensmitteln.
In: Borsdorf R, Lüdewald I, Wisser H (Hrsg.), Analytiker Taschenbuch, Bd. 20. Berlin: Springer, 1998. S. 3-44

Vieths S, May S, Haustein D (1998): Qualität von Allergenextrakten.
Bundesgesundhbl 41: 12-17.

Wagener S, Dittmar MT, Beer B, König R, Plesker R, Norley S, Kurth R, Cichutek K (1998): The U3 Promoter and the nef Gene of Simian Immunodeficiency Virus (SIV) smmPBj1.9 Do Not Confer Acute Pathogenicity upon SIVagm.
J. Virol 72: 3446-3450.

Wegener M, Bruckner L, Cußler K (1998): The establishment of endotoxin limits which satisfy animal welfare considerations in the testing of porcine vaccines.
Altex 15: 65-67.
Online-Abstract

Wesch D, Hinz T, Kabelitz D (1998): Analysis of the T cell receptor Vg repertoire in healthy donors and HIV-1 infected individuals.
Int. Immunol 10: 1067-1075.
Online-Abstract

Wesch D, Marx S, Kabelitz D (1998): Monocyte dependent death of freshly isolated T lymphocytes: Induction by phorbolester and mitogens and differential effects of catalase.
J. Immunol 161: 1248-1256.

Zwerger C, Plesker P, Papadopulos K, Cußler K, Hartinger J (1998): Vergleich kommerziell erhältlicher Adjuvantien bei BALB/c-Mäusen mit einem schwach immunogenen Peptid als Antigen.
Altex 15: 83-86.
Online-Abstract

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