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Publications in 2005

Authors from the Paul-Ehrlich-Institut are highlighted in bold face type. Where online abstracts or full texts are available of the publications, there is a link to these texts.

Baethge C, Blumentritt H, Berghöfer A, Bschor T, Glenn T, Adli M, Schlattmann P, Bauer M, Finke R (2005): Long-term lithium treatment and thyroid antibodies – a controlled study.
J Psychiatry Neurosci 30: 423-427.
Online-Abstract

Ballmer-Weber BK, Wangorsch A, Bohle B, Kaul S, Kündig T, Fötisch K, van Ree R, Wüthrich B, Vieths S (2005): Component-resolved in vitro diagnosis in carrot allergy: Does the use of recombinant carrot allergen improve the reliability of the diagnostic procedure?.
Clin Exp Allergy 35: 970-978.
Online-Abstract

Blümel J, Eis-Hübinger A, Stühler A, Bönsch C, Gessner M, Löwer J (2005): Characterization of parvovirus b19 genotype 2 in KU812 Ep6 cells.
J Virol 79: 14197-14206.
Online-Abstract

Bohle B, Radakovics A, Lüttkopf D, Jahn-Schmid B, Vieths S, Ebner C (2005): The characterization of the T cell response to the major hazelnut allergen, Cor a 1.04, indicates food allergen-specific epitopes not cross-reactive with tree pollen allergens.
Clin Exp Allergy 35: 1392-1399.
Online-Abstract

Boldt A, Fortunato D, Conti A, Petersen A, Ballmer-Weber B, Lepp U, Reese G, Becker WM (2005): Analysis of the composition of an immunoglobulin E reactive high molecular weight protein complex of peanut extract containing Ara h 1 and Ara h 3/4.
Proteomics 5: 675-686.
Online-Abstract

Bolhaar STHP, van Ree R, Ma Y, Bruijnzeel-Koomen CAFM, Vieths S, Hoffmann-Sommergruber K, Knulst AC, Zuidmeer L (2005): Severe allergy to sharon fruit caused by birch pollen.
Int Arch Allergy Immunol 136: 45-52.
Online-Abstract

Cichutek K (2005): Grundlagen der klinischen Prüfung von Arzneimitteln.
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 48: 395-396.
Text

Collin N, Guérin JL, Drexler I, Blanié S, Gelfi J, Boullier S, Foucras G, Sutter G, Messud-Petit F (2005): The poxviral scrapin MV-LAP requires a myxoma viral infection context to efficiently downregulate MHC-I molecules.
Virology 343: 171-178.

Dejas-Eckertz P, Schäffner G (2005): Beratung im Vorfeld klinischer Prüfungen durch die Bundesoberbehörde und Scientific Advice bei der EMEA.
Bundesgesundheitsbl-Gesundheitsforsch-Gesundheitsschutz 48: 423-428.
Online-Abstract Text

Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B (2005): Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.
J Biol Chem 280: 30797-30806.
Online-Abstract

Etscheid M, Beer N, Dodt J (2005): The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration.
Cell Signal 17: 1486-1494.
Online-Abstract

Finger C, Sun Y, Sanz L, Alvarez-Vallina L, Buchholz CJ, Cichutek K (2005): Replicating retroviral vectors mediating continuous production and secretion of therapeutic gene products from cancer cells.
Cancer Gene Therapy 12: 464-474.
Online-Abstract

Funk MB, Notheis G, Schuster T, von Hentig N, Stürmer M, Wintergerst U, Kreuz W (2005): Effect of First Line Therapy Including Efavirenz and Two Nucleoside Reverse Transcriptase Inhibitors in HIV-infected Children.
Eur J Med Res 10: 503-508.
Online-Abstract

Gonin P, Buchholz CJ, Pallardy M, Mezzina M (2005): Gene therapy bio-safety: scientific and regulatory issues.
Gene Ther 12: S146-S152.
Online-Abstract

Grundmann C, Plesker R, Kusch M, Hanschmann KM, Eich S, Seitz R, König H (2005): Prothrombin overload causes thromboembolic complications in prothrombin complex concentrates: In vitro and in vivo evidence.
Thromb Haemost 94: 1338-1339.
Online-Abstract

Hartl I, Schneider RM, Sun Y, Medvedovska J, Chadwick MP, Russel SJ, Cichutek K, Buchholz CJ (2005): Library-based selection of retroviruses selectively spreading through matrix metalloprotease-positive cells.
Gene Ther 12: 918-926.

Haschberger B, Waterkamp A, Heiden M, Seitz R (2005): Bericht zur Meldung nach §21 TFG für die Jahre 2001 und 2002.
Bundesgesundheitsbl - Gesundheitsforsch-Gesunheitsschutz 48: 99-119.
Online-Abstract Text

Henzgen M, Vieths S, Reese I, Erdmann S, Fuchs T, Jäger L, Kleine-Tebbe J, Lepp U, Niggemann B, Saloga J, Vieluf I, Zuberbier T, Werfel T (2005): Nahrungsmittelallergien durch immunologische Kreuzreaktionen.
Allergologie 28: 177-190.

Hoffmann A: Sicherheit von Impfstoffen - welchen Beitrag können die praktizierenden Tierärzte leisten?.
In: Bpt-Akademie (Hrsg.), bpt-Kongress 2005 Vortragsband Schwein - Rind - Praxisführung. 22.-25. September 2005 in Bremen. Frankfurt a. M.: Bpt-Akademie, 2005. 99-102.

Hoffmann S, Lüderitz-Püchel U, Montag T, Hartung T (2005): Optimisation of pyrogen testing in parenterals according to different pharmacopeias by probabilistic modeling.
J Endotoxin Res 11: 25-31.
Online-Abstract

Hoffmann A, Mergel A, Cußler K (2005): Unerwünschte Wirkungen nach Applikation immunologischer Arzneimittel beim Tier: Zusammenfassung der im Jahr 2004 im Paul-Ehrlich-Institut eingegangenen Meldungen.
Dtsch Tierärztebl 53: 1358-1361.
Volltext

Hoffmann A, Mergel A, Cußler K (2005): Unerwünschte Wirkungen nach Applikation immunologischer Arzneimittel beim Tier: Zusammenfassung der 2003 eingegangenen Meldungen.
Dtsch Tierärztbl 53: 14-16.
Volltext

Hoffmann S, Peterbauer A, Schindler S, Fennrich S, Poole S, Mistry Y, Montag-Lessing T, Spreitzer I, Löschner B, van Aalderen M, Bos R, Gommer M, Nibbeling R, Werner-Felmayer G, Loitzl P, Jungi T, Brcic M, Brugger P, Frey E, Bowe G, Casado J, Coecke S, de Lange J, Mogster B, Naess LM, Aaberge IS, Wendel A, Hartung T (2005): International validation of novel pyrogen tests based on human monocytoid cells.
J Immunol Methods 298: 161-173.

Huber C, Thielen C, Seeger H, Schwarz P, Montrasio F, Wilson MR, Heinen E, Fu YX, Miele G, Aguzzi A (2005): Lymphotoxin-ß receptor-dependent genes in lymph node and follicular dendritic cell transcriptomes.
J Immunol 174: 5526-5536.
Online-Abstract

Jahn-Schmid B, Radakovics A, Lüttkopf D, Scheurer S, Vieths S, Ebner C, Bohle B (2005): Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens.
J Allergy Clin Immunol 116: 213-219.
Online-Abstract

King N, Connaughton C, Helm R, Stanley SJ, Vieths S, Lüttkopf D, Hatahet L, Sampson HA, Pons L, Burks W, Bannon GA (2005): Allergenic characteristics of a modified peanut allergen.
Mol Nutr Food Res 49: 963-971.
Online-Abstract

König H, Rosenkranz S, Nawrot R, Hunfeld A, Seitz (2005): FVIII test in reference preparations: Compensation for different dilutions.
Pharmeuropa Scientific Notes 2005-1: 11-13.

Koppelman MH, Assal A, Chudy M, Torres P, de Villaescusa RG, Reesink HW, Lelie PN, Cuypers HT (2005): Multicenter performance evaluation of a transcription-mediated amplification assay for screening of human immunodeficiency virus-1 RNA, hepatitis C virus RNA, and hepatitis B virus DNA in blood donations.
Transfusion 45: 1258-1266.
Online-Abstract

Krafft H (2005): Die EudraCT-Datenbank bei der EMEA zur Erfassung klinischer Prüfungen in Europa.
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 48: 453-458.
Online-Abstract Text

Krafft H, Cichutek K (2005): Approval of clinical trials of immunobiological medicinal products at the Paul Ehrlich Institute.
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 48: 168-172.
Online-Abstract

Kremer M, Bittner A, Schnierle BS (2005): Human APOBEC3G incorporation into murine leukemia virus particles.
Virology 337: 175-182.
Online-Abstract

Kremer M, Schnierle BS (2005): HIV-1 Vif: HIV's Weapon Against the Cellular Defense Factor APOBEC3G.
Curr HIV Res 3: 339-344.

Krug M, Hausleithner D, Taddey R, Volkers P, Kobe B, Cußler K (2005): Serologische Testmethoden als Ersatz für Infektionsversuche an Ferkeln zur Wirksamkeitsprüfung von E.coli-Muttertierimpfstoffen. (Serological test methods as replacementfor infection trials in piglets to test the potency of E.coli vaxxines for sows).
ALTEX 22: 111-116.
Online-Abstract

Kupfer K, Ruf T, Matz B, Nattermann J, Spengler U, Rochstroh JK, Brackmann HH, Blümel J, Tacke M, Kaiser R (2005): Comparision of GB virus C, HIV, and HCV infection markers in haemophiliacs exposed to non-inactivated or inactivated factor concentrates.
J Clin Virol 34: 42-47.
Online-Abstract

Löchelt M, Romen F, Bastone P, Muckenfuss H, Kirchner N, Kim YB, Truyen U, Rösler U, Battenberg M, Saib A, Flory E, Cichutek K, Münk C (2005): The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein.
Proc Natl Acad Sci Epub May 23; 102: 7982-7987.
Online-Abstract

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) Langen (Hessen).
Löwer J, Vieths S (Hrsg.), Regulatory Control and Standardization of Allergenic Extracts: 11th International Paul-Ehrlich-Seminar September 29 - October 1, 2005, Hotel Steigenberger, Bad Homburg. Wiesbaden: Chmielorz, 2005. 270 S. ISBN 3-87124-333-7
(Arbeiten aus dem Paul-Ehrlich-Institut 95)

Lopata AL, Jeebhay MF, Reese G, Fernandes J, Swoboda I, Robins TG, Lehrer SB (2005): Detection of fish antigens aerosolized during fish processing using newly developed immunoassays.
Int Arch Allergy Immunol 138: 21-28.
Online-Abstract

Ludwig H, Mages J, Staib C, Lehmann M, Lang R, Sutter G (2005): Role of viral factor E3L in modified vaccinia virus ankara infection of human cells - regulation of the virus life cycle and identification of differentially expressed host genes.
J Virol 79: 2584-2596.
Online-Abstract

Mari A, Ballmer-Weber BK, Vieths S (2005): The oral allergy syndrome: improved diagnostic and treatment methods.
Curr Opin Allergy Clin Immunol 5: 267-273.
Online-Abstract

Merten CA, Stitz J, Braun G, Poeschla EM, Cichutek K, Buchholz CJ (2005): Directed evolution of retrovirus envelope protein cytoplasmic tails guided by functional incorporation into lentivirus particles.
J Virol 79: 834-840.
Online-Abstract

Meyer R, Britten C, Siepmann U, Petzold B, Sagban T, Lehr H, Weigle B, Schmitz M, Mateo L, Schmidt B, Bernhard H, Jakob T, Hein R, Schuler G, Schuler-Thurner B, Wagner S, Drexler I, Sutter G, Arndtz N, Chaplin P, Enk A, Huber C, Wölfel T (2005): A phase I vaccination study with tyrosinase inpatients with stage II melanoma using recombinant modified vaccinia virus Ankara (MVA-hTyr).
Cancer Immunol Immunother Epub 2004 Dec 31; 54: 453-467.
Online-Abstract

Mittag D, Vieths S, Vogel L, Wagner-Löw D, Starke A, Hunziker P, Becker WM, Ballmer-Weber BK (2005): Birch pollen-related food allergy to legumes: identification and characterization of the Bet v 1 homologue in mungbean (Vigna radiata), Vig r 1.
Clin Exp Allergy 35: 1049-1055.
Online-Abstract

Mühlebach MD, Wolfrum N, Schüle S, Tschulena U, Sanzenbacher R, Flory E, Cichutek K, Schweizer M (2005): Stable Transduction of Primary Human Monocytes by Simian Lentiviral Vector PBj.
Mol Ther 12: 1206-1216.

Niebert M, Tönjes RR (2005): Evolutionary spread and recombination of porcine endogenous retroviruses in the suiformes.
J Virol 79: 649-654.
Online-Abstract

Nikles D, Bach P, Boller K, Merten CA, Montrasio F, Heppner FL, Aguzzi A, Cichutek K, Kalinke U, Buchholz CJ (2005): Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP.
J Virol 79: 4033-4042.
Online-Abstract

Paschen A, Jing W, Drexler I, Klemm M, Song M, Müller-Berghaus J, Nguyen XD, Osen W, Stevanovic S, Sutter G, Schadendorf D (2005): Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2.
Int J Cancer Epub Apr 26; 116: 944-948.
Online-Abstract

PEI (2005): BHV-1-Serokonversionen nach Impfung mit kontaminiertem Impfbesteck.
Deutsches Tierärzteblatt 53: 401.
Volltext

Pfleiderer M (2005): Die Zulassung von Influenzaimpfstoffen - vom saisonal aktualisierten Impfstoff zum Pandemiefall : Wissenschaftliche und regulatorische Anmerkungen zu bewährten und neuen Konzepten zur Herstellung von Influenzaimpfstoffen.
ImpfDialog 4/2005: 175-182.
Volltextversion des Artikels als pfd-Datei auf der Website des ImpfDialog

Plesker R, Hetzel U, Schmidt W (2005): Cataracts in a Laboratory Colony of African Green Monkeys (Chlorocebus aethiops).
J Med Primatol 34: 139-146.
Online-Abstract

Plesker R, Hetzel U, Schmidt W (2005): Two cases of spontaneous high myopia in a colony of rhesus macaques (Macaca mulatta).
Verhandlungsbericht des 42. Internationalen Symposium über die Erkrankung der Zoo- und Wildtiere 42: 148-152.

Quinnan G, Yu X, Lewis M, Zhang P, Sutter G, Silvera P, Dong M, Choudhary A, Sarkis P, Bouma P, Zhang Z, Montefiori D, VanCott T, Broder C (2005): Protection of rhesus monkeys against infection with minimally pathogenic simian-human immunodeficiency virus: correlations with neutralizing antibodies and cytotoxic T cells.
J Virol 79: 3358-3369.
Online-Abstract

Reese G, Viebranz J, Leong-Kee SM, Plante M, Lauer I, Randow S, Moncin MS, Ayuso R, Lehrer SB, Vieths S (2005): Reduced Allergenic Potency of VR9-1, a Mutant of the Major Shrimp Allergen Pen a 1 (Tropomyosin).
J Immunol 175: 8354-8364.
Online-Abstract

Reuter A, Fortunato D, Perono Garoffo L, Napolitano L, Scheurer S, Giuffrida MG, Vieths S, Conti A (2005): Novel isoforms of Pru av 1 with diverging IgE properties identified by a synergistic combination of molecular biology and proteomics.
Proteomics 5: 282-289.
Online-Abstract

Rohn TA, Schadendorf D, Sun Y, Nguyen XD, Roeder D, Langen H, Vogt AB, Kropshofer H (2005): Melanoma cell necrosis facilitates transfer of specific sets of antigens onto MHC class II molecules of dendritic cells.
Eur J Immunol 35: 2826-2839.
Online-Abstract

Rosskopf U, Noeske K, Werner E (2005): Replacement of the in vivo Neutralisationtest for Efficacy Demonstration of Tetanus Vaccines ad us. vet.
Altex 22: 169-174.
Online-Abstract

Rosskopf U, Noeske K, Werner E (2005): Efficacy Demonstration of Tetanus Vaccines by Double Antigen ELISA.
Pharmeuropa Bio 2005-1: 31-52.
Online-Abstract

Saldanha, Heath A, Lelie N, Pisani G, Yu MY, Collaborative Study Group (2005): A World Health Organization International Standard for hepatitis A virus RNA nucleic acid amplification technology assays.
Vox Sang 89: 52-58.
Online-Abstract

Schäd SG, Trcka J, Vieths S, Scheurer S, Conti A, Bröcker EB, Trautmann A (2005): Wine anaphylaxis in a German patient: IgE-mediated allergy against a lipid transfer protein of grapes.
Int Arch Allergy Immunol 136: 159-164.
Online-Abstract

Schildgen O, Gräper S, Blümel J, Matz B (2005): Genome replication and progeny virus production of herpes simplex virus type 1 mutants with temperature-sensitive lesions in the origin-binding protein.
J Virol 79: 7273-7278.
Online-Abstract

Schimek EM, Zwölfer B, Briza P, Jahn-Schmid B, Vogel L, Vieths S, Ebner C, Bohle B (2005): Gastrointestinal digestion of Bet v 1-homologous food allergens destroys their mediator releasing but not T cell-activating capacity.
J Allergy Clin Immunol 116: 1327-1333.
Online-Abstract

Schmidt M, Weis C, Heck L, Montag T, Nicol SB, Hourfar MK, Schaefer, Sireis W, Roth WK, Seifried E (2005): Optimized Scansystem platelet kit for bacterial detection with enhanced sensitivity: detection within 24 h after spiking.
Vox Sang 89: 135-139.
Online-Abstract

Schwanig M, Löwer J: Herstellung und Prüfung von Impfstoffen.
In: Spiess H, Heininger U (Hrsg.), Impfkompendium. 6. Auflage Stuttgart: Thieme, 2005. 10-25 ISBN 3-13-498906-9

Seitz R, Blümel J, Burger R, Gerlich W, Gürtler L, Heiden M, Hitzler W, Jansen B, Klamm H, Lefévre H, Löwer J, Ludwig WD, Montag T, Offergeld R, Paessens A, Pauli G, Schlenkrich U, Schottstedt V, Willkommen H, Baljer G (2005): Coxiella burnetii – Erreger des Q- (query) Fiebers.
Bundesgesundheitsbl – Gesundheitsforsch – Gesundheitsschutz 48: 814-821.
Online-Abstract

Seitz R, Blümel J, Burger R, Gerlich W, Gürtler L, Heiden M, Hitzler W, Jansen B, Klamm H, Lefévre H, Löwer J, Ludwig WD, Montag-Lessing T, Offergeld, Paessens A, Pauli G, Schlenkrich U, Schottstedt V, Willkommen H (2005): Coxiella burnetii – Pathogen of the Q (Query) Fever.
Transfus Med Hemother 32: 218-226.
Online-Abstract

Seitz R, Blümel J, Burger R, Gerlich W, Gürtler L, Heiden M, Hitzler W, Jansen B, Klamm H, Lefèvre H, Löwer J, Ludwig WD, Montag-Lessing T, Offergeld R, Paessens A, Pauli G, Schlenkrich U, Willkommen H (2005): Arboviruses – Viruses Transmissible by Arthropods.
Transfus Med Hemother 32: 24-32.
Online-Abstract

Seitz R, Blümel J, Burger R, Gerlich W, Gürtler L, Heiden M, Hitzler W, Jansen B, Klamm H, Ludwig WD, Lefévre H, Montag-Lessing T, Offergeld R, Neumann R, Paessens A, Pauli G, Schlenkrich U, Schottstedt V, Willkommen H, Beekes M, Zerr I (2005): Variant Creutzfeldt-Jakob-Disease.
Transfus Med Hemother 32: 227-236.
Online-Abstract

Seitz R, Blümel J, Burger R, Gerlich W, Gürtler L, Heiden M, Hitzler W, Jansen B, Klamm H, Ludwig WD, Montag-Lessing T, Offergeld R, Passens A, Pauli G, Schlenkrich U, Schottstedt V, Willkommen H, Beekes M, Zerr I (2005): Variante Creutzfeldt-Jakob-Krankheit.
Bundesgesundheitsbl – Gesundheitsforsch – Gesundheitsschutz 48: 1082-1090.
Online-Abstract

Siegert S, Thaler S, Wagner R, Schnierle BS (2005): Assessment of HIV-1 entry inhibitors by MLV/HIV-1 pseudotyped vectors.
AIDS Res Ther 2: 7.
Online-Abstract

Staib C, Kisling S, Erfle V, Sutter G (2005): Inactivation of the viral interleukin 1ß receptor improves CD8+T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara.
J Gen Virol 86: 1997-2006.
Online-Abstract

Strobl B, Bubic I, Bruns U, Steinborn R, Lajko R, Kolbe T, Karaghiosoff M, Kalinke U, Jonjic S, Muller M (2005): Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus.
J Immunol 175: 4000-4008.
Online-Abstract

Sun Y, Finger C, Alvarez-Vallina L, Cichutek K, Buchholz CJ (2005): Chronic gene delivery of interferon-inducible protein 10 through replication-competent retrovirus vectors suppresses tumor growth.
Cancer Gene Ther 12: 900-912.
Online-Abstract

Urban JH, Schneider RM, Compte M, Finger C, Cichutek K, Alvarez-Vallina L, Buchholz CJ (2005): Selection of functional human antibodies from retroviral display libraries.
Nucleic Acids Res 33: e35.

Vogel L, Lüttkopf D, Hatahet L, Haustein D, Vieths S (2005): Development of a functional in vitro assay as a novel tool for the standardization of allergen extracts in the human system.
Allergy 60: 1021-1028.
Online-Abstract

Volkers P, Poley-Ochmann S, Nübling CM (2005): Regulatorische Aspekte klinischer Prüfungen unter besonderer Berücksichtigung biologischer Arzneimittel.
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 48: 408-414.
Online-Abstract Text

Wessler S, Münzner P, Meyer TF, Naumann M (2005): The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection.
Biol Chem 386: 481-490.
Online-Abstract

Wiche R, Gubesch M, König H, Fötisch K, Hoffmann A, Wangorsch A, Scheurer S, Vieths S (2005): Molecular basis of pollen-related food allergy: identification of a second cross-reactive IgE epitope on Pru av 1, the major cherry (Prunus avium) allergen.
Biochem J 385: 319-327.
Online-Abstract

Zingler N, Weichenrieder O, Schumann GG (2005): APE-type non-LTR retrotransposons: determinants involved in target site recognition.
Cytogenetic and Genome Research 110: 250-268.
Online-Abstract

Zingler N, Willhoeft U, Brose HP, Schoder V, Jahns T, Hanschmann KMO, Morrish TA, Löwer J, Schumann GG (2005): Analysis of 5´ junctions of human LINE-1 and Alu retrotransposons suggests an alternative model for 5´ end attachment requiring microhomology-mediated end joining.
Genome Res 15: 780-789.
Online-Abstract

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