Monoclonal antibodies for use against the SARS-CoV-2 coronavirus are proteins of the immune system (immunoglobulins) which have been developed to specifically bind to defined surface structures of the SARS-CoV-2 coronavirus. These antibodies are directed against the surface spike protein of SARS-CoV-2.

In contrast to hyperimmune globulins, convalescent plasma and sera, monoclonal antibodies consist of identical immunoglobulin molecules with a single amino acid sequence and a single recognition domain for a specific structure (epitope) of a single specific target molecule (antigen). Monoclonal antibody medicinal products may also contain combinations of a small number of precisely specified monoclonal antibodies; this is indicated in the composition of the medicinal product.

Updated: 28.03.2024

These antibodies work by binding to the spike protein on the surface of the SARS-CoV-2 coronavirus. In this way, they block the SARS-CoV-2 viruses from binding to the receptors on the surface of human cells. As a result, the viruses cannot penetrate the cells and infect them. As viruses reproduce in cells and are released by the infected cells, the neutralisation of viral entry and infection of the cells is also associated with the prevention of viral reproduction (replication).

Updated: 28.03.2024